Browsing by Subject "Neurosciences & Neurology"

Now showing 1 - 16 of 16
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    Advances in Color Science: From Retina to Behavior (vol 30, pg 14955, 2010)
    (JOURNAL OF NEUROSCIENCE, 2010-12-08) Conway, Bevil R; Chatterjee, Soumya; Field, Greg D; Horwitz, Gregory D; Johnson, Elizabeth N; Koida, Kowa; Mancuso, Katherine
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    Auditory-perceptual analysis of dysarthria in bilateral striatopallidodentate calcinosis (fahr's disease)
    (Journal of Medical Speech-Language Pathology, 2012-03-01) Jacks, A; Haley, KL; Scott, BL; Jones, H
    A 53-year-old woman with bilateral striatopallidodentate calcinosis (BSPDC) was referred for motor speech examination, and high-quality acoustic recordings were obtained. Three speech-language pathologists experienced in auditory-perceptual assessment of speakers with dysarthria scored 47 auditory-perceptual speech features using a 5-point equal- Appearing interval scale. Results of consensus agreement found speech to be characterized by breathy dysphonia, hypemasality, imprecise consonants, irregular articulatory breakdowns, slow rate, short phrases, and excess and equal stress. Speech signs appeared most consistent with a moderate mixed ataxic-hypokinetic dysarthria. The ataxic component predominated and was distinguished by the speech features of excess and equal stress and irregular articulatory breakdowns. Distinctive speech features of hypokinetic dysarthria included monopitch, breathy phonation, reduced loudness, and variable rate. To our knowledge, this is the first comprehensive report of the dysarthria encountered in BSPDC and can serve as a foundation for future research into dysarthria in this condition. Copyright © 2012 Delmar Cengage Learning.
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    Correction: Progressive decline in hippocampal CA1 volume in individuals at ultra-high-risk for psychosis who do not remit: findings from the longitudinal youth at risk study.
    (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019-11) Ho, New Fei; Holt, Daphne J; Cheung, Mike; Iglesias, Juan Eugenio; Goh, Alex; Wang, Mingyuan; Lim, Joseph KW; de Souza, Joshua; Poh, Joann S; See, Yuen Mei; Adcock, R Alison; Wood, Stephen J; Chee, Michael WL; Lee, Jimmy; Zhou, Juan
    An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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    Fundamental frequency and intensity mean and variability before and after two behavioral treatments for aprosodia
    (Journal of Medical Speech-Language Pathology, 2009-03-01) Jones, HN; Shrivastav, R; Wu, SS; Plowman-Prine, EK; Rosenbek, JC
    Emerging data suggest that aprosodia may be amenable to behavioral treatment. This study investigated the use of acoustic analysis of speech to quantify response to two speech treatments previously judged to have an effect based on perceptual assessment in three participants with primarily expressive aprosodia. The mean and variability of fundamental frequency (F0) and intensity (INT) during production of sentences requiring use of four different emotional tones of speech (i.e., happy, angry, sad, or neutral) was calculated before and after two mechanism-based treatments for aprosodia (i.e., TX1 and TX2). Statistical differences in F0 mean and variability were primarily observed following TX1, whereas differences in INT mean and variability were principally revealed following TX2. Additionally, significant differences in these acoustic values were noted across almost all pairwise comparisons of emotional sentence types (i.e., angry vs. sad, happy vs. sad, neutral vs. sad, angry vs. neutral, and happy vs. neutral). These preliminary data suggest that perceptual improvements in aprosodia can be measured quantitatively using acoustic analysis of speech and provide additional support for previously described behavioral treatments for this disorder. These findings also support previous reports that suggest that different emotional tones of speech are associated with differences in the acoustic speech signal. Copyright © 2009 Delmar Cengage Learning.
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    General anesthetics activate a potent central pain-suppression circuit in the amygdala.
    (Nature neuroscience, 2020-05-18) Hua, Thuy; Chen, Bin; Lu, Dongye; Sakurai, Katsuyasu; Zhao, Shengli; Han, Bao-Xia; Kim, Jiwoo; Yin, Luping; Chen, Yong; Lu, Jinghao; Wang, Fan
    General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA suppresses pain in part by activating supraspinal analgesic circuits. We discovered a distinct population of GABAergic neurons activated by GA in the mouse central amygdala (CeAGA neurons). In vivo calcium imaging revealed that different GA drugs activate a shared ensemble of CeAGA neurons. CeAGA neurons also possess basal activity that mostly reflects animals' internal state rather than external stimuli. Optogenetic activation of CeAGA potently suppressed both pain-elicited reflexive and self-recuperating behaviors across sensory modalities and abolished neuropathic pain-induced mechanical (hyper-)sensitivity. Conversely, inhibition of CeAGA activity exacerbated pain, produced strong aversion and canceled the analgesic effect of low-dose ketamine. CeAGA neurons have widespread inhibitory projections to many affective pain-processing centers. Our study points to CeAGA as a potential powerful therapeutic target for alleviating chronic pain.
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    Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity.
    (Glia, 2018-02) Hanamsagar, Richa; Alter, Mark D; Block, Carina S; Sullivan, Haley; Bolton, Jessica L; Bilbo, Staci D
    © 2017 Wiley Periodicals, Inc. Glia. 2017 Sep; 65 (9),1504–1520. DOI:10.1002/glia.23176. The above referenced article was published with an incorrect image and legend for Figure. The authors apologize for this error and provide the correct Figure and legend below: (Figure presented.) Gene expression changes in microglia following an immune challenge are related to development. Top 1,000 genes were selected between different group comparisons to input into DAVID gene functional annotation software (https://david.ncifcrf.gov/tools.jsp). Top seven highly enriched gene functional groups were chosen for representation of group differences: (a) P60 vs. E18, (b) P60 females vs. males, (c) P60 male LPS vs. SAL, (d) P60 female LPS vs. SAL. Immune response genes are represented as green bars, membrane protein and signaling molecules as purple bars, and miscellaneous genes as orange bars. (e) Heat map of gene expression changes depicts upregulation or downregulation of individual genes in different group comparisons. Red = upregulation, blue = downregulation [Color figure can be viewed at wileyonlinelibrary.com].
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    International normalized ratio Response
    (JOURNAL OF NEUROSURGERY, 2011-01-01) West, Kelly L; Adamson, Cory; Hoffman, Maureane
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    Minimally Invasive Posterior Cervical Foraminotomy
    (Clinical Spine Surgery: A Spine Publication, 2017-12) Peto, Ivo; Scheiwe, Christian; Kogias, Evangelos; Hubbe, Ulrich
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    Molding Idle Musings Into Art: What Reflective Writing Does for Me?
    (Journal of pain and symptom management, 2019-04) Brown, J Trig
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    Movement Disorder Society-Unified Parkinson's Disease Rating Scale Use in the Covid-19 Era.
    (Movement disorders : official journal of the Movement Disorder Society, 2020-04-22) Goetz, Christopher G; Stebbins, Glenn T; Luo, Sheng
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    Outcomes of Operative and Nonoperative Treatment for Adult Spinal Deformity
    (Neurosurgery, 2016-09) Smith, JS; Lafage, V; Shaffrey, C
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    Retinal Representation of the Elementary Visual Signal
    (Neuron, 2014-04) Li, PH; Field, GD; Greschner, M; Ahn, D; Gunning, DE; Mathieson, K; Sher, A; Litke, AM; Chichilnisky, EJ
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    THE EFFECT OF RILUZOLE ON INTRAMEDULLARY LESION LENGTH AND DTI, RATIONALE AND DESIGN OF RISCIS MRI-SUBSTUDY
    (JOURNAL OF NEUROTRAUMA, 2018-08-01) Aarabi, Bizhan; Fehlings, Michael G; Robertson, Claudia S; Shaffrey, Christopher; Kurpad, Shekar; Ray, Wilson Z
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    The Prevalence of Incidental and Symptomatic Lumbar Synovial Facet Cysts
    (Clinical Spine Surgery: A Spine Publication, 2018-06) Janssen, Stein J; Ogink, Paul T; Schwab, Joseph H