Browsing by Subject "Older adults"
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Item Open Access Assessing the Hierarchical Healthcare System for Common Mental Disorders in Older Adults: a Mixed Method Study in Kunshan(2024) Fu, ZiyuAbstractBackground: Common mental disorders (CMDs) can be defined as depression and anxiety, which have a great influence on the quality of life among older adults. CMDs are becoming a serious public health problem among the older adult population, especially depression. Effective management can improve the overall well-being of older adults. The policy significance of combining the hierarchical healthcare system (HHS) and CMDs is to promote the screening of high-risk elderly groups represented by depression, promote the prevention system of early detection, diagnosis, and treatment of elderly diseases, improve the early prevention and management mechanism of mental disorders, improve the psychological serviceability of older adults, and achieve healthy aging. This study aims to investigate the attitudes of older adults in Kunshan towards mental health services in the community and to assess the conditions and challenges of HHS for older adults’ CMDs in Kunshan. Methods: The quantitative analytical sample is restricted to older adults aged over 60 years who lived in Tinglin or Jinxi communities in Kunshan and who responded to the attitude survey (n=100). Attitudes were measured by asking older adults about their willingness or concern for community mental health services. The two-sample t-test and the chi-square test were used to compare the characteristics of the Tinglin and Jinxi communities. Logistic regression was used to determine the adjusted associations between sex, education, and attitudes related to managing common mental disorders in two communities. The qualitative data is obtained from semi-structured qualitative interviews with 7 relevant experts from 7 medical or social departments in Kunshan, including Jinxi People's Hospital, Jinxi Community Health Center (CHC), Mental Disorders Prevention and Treatment Department (MDPTD) of CHC in Jinxi, Kunshan Mental Health Center (KMHC), Kunshan First People's Hospital, Tinglin Community, and the Civil Affairs Bureau (CAB). The semi-structured interview was designed around the current situation of medical systems and mental health services in Kunshan, challenges in managing CMDs in older adults, and science communication for mental health. All interviews will be imported into Nvivo 12 for thematic analysis through grounded theory. Results: 74% of participants from Tinglin have an education level of Grade 9 and above, but only 28% of those from Jinxi at the same educational attainment. Tinglin residents demonstrated higher levels of understanding and acceptance of mental health. 60% of participants from Tinglin understand mental health, while only 18% in Jinxi. Tinglin residents (17%) show a higher willingness to seek professional treatment compared to Jinxi (4%). Tinglin (68%) exhibited a more favorable attitude towards community-recommended treatment compared to Jinxi (36%). Residents in Tinglin (50%) expressed the necessity of professional psychiatrists in the community, while only 14% in Jinxi. However, only 30% of residents in Tinglin showed a low will to cooperate, while 66% in Jinxi. It was also found that there was a significant association between education level and attitudes towards mental health in older adults. The qualitative results first introduced Kunshan’s family physicians and HHS model, management of severe mental disorders (SMD), screening for dementia, daily care center (DCC) and psychiatric rehabilitation station (PRS), and social workers policy. These provide guidance and experience for the implementation of management of CMD in the elderly. However, the implementation of HHS for older adults’ CMDs is hampered by multiple obstacles from older adults, their families, communities, the medical system, society, and the government. The interviewees also stressed the importance of science communication. Conclusions: With the current level of social development and medical resources, implementing HHS for the CMDs in older adults in Kunshan faces many difficulties at this stage.
Item Open Access Association between perceived risk of Alzheimer's disease and related dementias and cognitive function among U.S. older adults.(Archives of gerontology and geriatrics, 2023-07) Wang, Nan; Xu, Hanzhang; West, Jessica S; Østbye, Truls; Wu, Bei; Xian, Ying; Dupre, Matthew EIntroduction
The aim of the study was to assess factors associated with the perceived risk of developing Alzheimer's disease and related dementias (ADRD) and how the perceived risk of ADRD was related to cognitive function.Methods
We conducted a retrospective cohort study using 5 waves of data from the Health and Retirement Study (2012-2022) that included adults aged 65 years or older with no previous diagnosis of ADRD at baseline. Cognitive function was measured at baseline and over time using a summary score that included immediate/delayed word recall, serial 7's test, objective naming test, backwards counting, recall of the current date, and naming the president/vice-president (range = 0-35). Perceived risk of developing ADRD was categorized at baseline as "definitely not" (0% probability), "unlikely" (1-49%), "uncertain" (50%), and "more than likely" (>50-100%). Additional baseline measures included participants' sociodemographic background, psychosocial resources, health behaviors, physiological status, and healthcare utilization.Results
Of 1457 respondents (median age 74 [IQR = 69-80] and 59.8% women), individuals who perceived that they were "more than likely" to develop ADRD had more depressive symptoms and were more likely to be hospitalized in the past two years than individuals who indicated that it was "unlikely" they would develop ADRD. Alternatively, respondnets who perceived that they would "definitely not" develop ADRD were more likely to be non-Hispanic Black, less educated, and have lower income than individuals who indicated it was "unlikely" they would develop ADRD. Respondents who reported their risks of developing ADRD as "more than likely" (β = -2.10, P < 0.001) and "definitely not" (β = -1.50, P < 0.001) had the lowest levels of cognitive function; and the associations were explained in part by their socioeconomic, psychosocial, and health status.Conclusions
Perceived risk of developing ADRD is associated with cognitive function. The (dis)concordance between individuals' perceived risk of ADRD and their cognitive function has important implications for increasing public awareness and developing interventions to prevent ADRD.Item Open Access Changes in perceived uselessness and risks for mortality: evidence from a National sample of older adults in China.(BMC Public Health, 2017-06-09) Zhao, Yuan; Dupre, Matthew E; Qiu, Li; Gu, DananBACKGROUND: Self-perception of uselessness is associated with increased mortality risk in older adults. However, it is unknown whether and to what extent changes in perceived uselessness are associated with mortality risk. METHODS: Using four waves of national longitudinal data of older adults from China (2005, 2008, 2011, and 2014), this study examines the association between changes in perceived uselessness and risk of subsequent mortality. Perceived uselessness is classified into three major categories: high levels (always/often), moderate levels (sometimes), and low levels (seldom/never). Five categories are used to measure change over three-year intervals: (1) persistently high levels, (2) increases to moderate/high levels, (3) persistent moderate levels, (4) decreases to moderate/low levels, and (5) persistently low levels. Cox proportional hazard models were used to estimate mortality risk associated with changes in levels of perceived uselessness. RESULTS: Compared to those with persistently low levels of perceived uselessness, those with persistently high levels of feeling useless had 80% increased hazard ratio (HR) in mortality [HR =1.80, 95% CIs: 1.57-2.08, p < 0.001]; and those with increasing levels, persistently moderate levels, and decreasing levels of perceived uselessness had 42% [HR = 1.42, 95% CIs: 1.27-159, p < 0.001], 50% [HR = 1.50, 95% CIs: 1.32-1.71, p < 0.001], and 23% [HR = 1.23, 95% CIs: 1.09-1.37, p < 0.001] increased hazard ratio in mortality, respectively, when background characteristics were taken into account. The associations were partially attenuated when socioeconomic, family/social support, behavioral, and health-related covariates were individually taken into account. Older adults with persistently high and moderate levels of perceived uselessness still exhibited significantly higher risks of mortality (16% [HR = 1.16, 95% CIs: 1.00-1.135, p < 0.05] and 22% [HR = 1.16, 95% CIs: 1.06-1.139, p < 0.015], respectively) after adjusting for all covariates, although no significant mortality risks were found for either increasing to moderate/high levels or decreasing to moderate/low levels of perceived uselessness. CONCLUSIONS: Persistently high and moderate levels of perceived uselessness are associated with significant increases in mortality risk. These findings have important implications for promoting successful aging in China.Item Open Access Combatting Social Isolation, Loneliness, and Elevated Suicide Risk Among Older Adults in North Carolina(2022-04) Hendel, Keren; Shipman, WillSocial isolation (the objective deficit in social relationships) and loneliness (the subjective deficit between an individual’s desired and actual social relationships) are public health issues that affect the health and well-being of many North Carolinians. The North Carolina Department of Health and Human Services (NC DHHS) seeks to develop a strategy to reduce social isolation, loneliness, and elevated suicide risk (SILES). Given the barriers to addressing SILES and the resources of NC DHHS, this strategy should include the formation of a task force, improved social isolation and loneliness screening, and support for community-based organizations. Social isolation and loneliness contribute to higher morbidity and mortality and are widespread. Social isolation and loneliness are associated with greater mortality and increased risk of stroke, heart disease, dementia, diabetes, high cholesterol, chronic conditions, anxiety, depression, and suicide. Prior to the COVID-19 pandemic, 43 percent of adults over age 60 in the United States reported feeling lonely and 25 percent of adults over age 65 were considered socially isolated. By the middle of the pandemic, almost two-thirds of people aged 50 and older in the nation reported social isolation. NC DHHS recognizes the importance of social isolation and loneliness. The Division of Aging and Adult Services (DAAS) developed a SILES working group in April 2020 to begin working to address these key public health issues. Later, DAAS encouraged the North Carolina Area Agencies on Aging to use Older American Act 2021 and various COVID-19 funding to support social connection. The Division of Health Benefits (North Carolina Medicaid) plans to use American Rescue Plan Act funding to address social isolation, loneliness, and elevated suicide risk among home and community-based services beneficiaries. The purpose of this report is to answer the following question: given the recent influx of funding to combat social isolation and loneliness, what strategy or strategies should the North Carolina Department of Health and Human Services pursue to combat these issues? Based on an environmental scan, expert interviews, analysis of the recently conducted Social Isolation and Loneliness in North Carolina Survey, a landscape review of current screenings being used in North Carolina, interviews with other states and large cities, and a guided discussion with NC DHHS stakeholders, we recommend that North Carolina initially focus on coordinated existing efforts throughout the state that aim to improve social connection among older adults. In particular, we recommend NC DHHS: 1. Creates a SILES task force that includes NC DHHS Divisions, community-based organizations, older adult advocates, and researchers. The task force should be led by an individual at NC DHHS who reports directly to executive leadership and for whom SILES work is a top priority of their role. 2. Incorporate the UCLA 3-Item Loneliness Scale into existing Medicaid HCBS screening tools and NCCARE360 screenings. Incorporate referrals to existing SILES programs into the NCCARE360 referral network. Referral services should build over time to include more SILES programs occurring in North Carolina, in particular, those that are targeted toward specific communities of high need. Screening can help identify high-need communities and populations to prioritize for the development of SILES pilots and programs. 3. Fund existing community efforts and pilots through grants. Grants should be awarded in a way that prioritizes innovative programs that support high-need groups and support the state’s goal to create a comprehensive, person-centered SILES approachItem Open Access Family Ties, Economic Resources, and the Well-Being of Older Adults Across Communities in China(2013) Sereny, Melanie DawnMany older adults in the developing world rely on their adult children for financial, instrumental, and emotional support. The People's Republic of China (PRC), which will experience rapid population aging in the current century, is no exception. Many scholars and policy-makers are concerned that rapid economic, social, and demographic change in China is leading to a decline in traditional support for aging parents. This study examines the impact of family ties and economic resources on the receipt of support and the health of older adults across communities in China at different levels of economic development.
I analyze data from the 2002 and 2008 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) as well as the 2000 and 2005 1% Chinese Census. Initiated in 1998, the CLHLS interviewed older adults residing in a random sample of counties and cities in 22 provinces and municipalities of China. Additionally, in 2002 a subset of adult children of CLHLS respondents were also interviewed in a separate survey. Furthermore, the 2008-2009 wave collected additional data from middle-aged and older adults residing in specially designated "longevity areas" in China. In addition to the standard questionnaire and health exam, samples of blood and urine were also collected by medical personnel.
The first empirical chapter of this dissertation examines the association between filial piety/altruism and financial transfers to aging parents from adult children using factor analysis, binary logistic regression, and linear regression. The second paper looks at the socioeconomic-status health gradient using biomarker data among older adults residing in longevity areas using binary logistic regression analysis. The third paper examines both individual-level and community-level determinants of non-normative intergenerational coresidence - living with an adult daughter instead of an adult son-- through multilevel binary logistic models analyzing both survey and census data.
I find that (1) adult children's attitudes towards filial piety and family values are associated with both presence and amount of financial transfers to older parents, net of controls for adult child's socioeconomic status, parental need, parents' earlier life transfers to children, and whether elderly parents' provide instrumental support to adult children. (2) Similar to previous research in middle-income countries, many biomarkers were not associated with socioeconomic status but those that were demonstrated a reversed gradient - higher socioeconomic status was associated with worse health. (3) Greater numbers of daughters, higher levels of individual socioeconomic status, and residing in a more developed community was associated with greater likelihood of coresidence with adult daughters versus adult sons.
Item Open Access Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults.(J Gerontol A Biol Sci Med Sci, 2016-10) Porter Starr, Kathryn N; Pieper, Carl F; Orenduff, Melissa C; McDonald, Shelley R; McClure, Luisa B; Zhou, Run; Payne, Martha E; Bales, Connie WBACKGROUND: Obesity is a significant cause of functional limitations in older adults; yet, concerns that weight reduction could diminish muscle along with fat mass have impeded progress toward an intervention. Meal-based enhancement of protein intake could protect function and/or lean mass but has not been studied during geriatric obesity reduction. METHODS: In this 6-month randomized controlled trial, 67 obese (body mass index ≥30kg/m(2)) older (≥60 years) adults with a Short Physical Performance Battery score of 4-10 were randomly assigned to a traditional (Control) weight loss regimen or one with higher protein intake (>30g) at each meal (Protein). All participants were prescribed a hypo-caloric diet, and weighed and provided dietary guidance weekly. Physical function (Short Physical Performance Battery) and lean mass (BOD POD), along with secondary measures, were assessed at 0, 3, and 6 months. RESULTS: At the 6-month endpoint, there was significant (p < .001) weight loss in both the Control (-7.5±6.2kg) and Protein (-8.7±7.4kg) groups. Both groups also improved function but the increase in the Protein (+2.4±1.7 units; p < .001) was greater than in the Control (+0.9±1.7 units; p < .01) group (p = .02). CONCLUSION: Obese, functionally limited older adults undergoing a 6-month weight loss intervention with a meal-based enhancement of protein quantity and quality lost similar amounts of weight but had greater functional improvements relative to the Control group. If confirmed, this dietary approach could have important implications for improving the functional status of this vulnerable population (ClinicalTrials.gov identifier: NCT01715753).Item Open Access Longitudinal associations between BMI change and the risks of colorectal cancer incidence, cancer-relate and all-cause mortality among 81,388 older adults : BMI change and the risks of colorectal cancer incidence and mortality.(BMC cancer, 2019-11-11) Li, Ji-Bin; Luo, Sheng; Wong, Martin CS; Li, Cai; Feng, Li-Fen; Peng, Jian-Hong; Li, Jing-Hua; Zhang, XiBACKGROUND:It remains controversial whether weight change could influence the risks of colorectal cancer (CRC) and mortality. This study aimed to quantify the associations between full-spectrum changes in body mass index (BMI) and the risks of colorectal cancer (CRC) incidence, cancer-related and all-cause mortality among midlife to elder population. METHODS:A total of 81,388 participants who were free of cancer and aged 55 to 74 years from the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening program were involved. The percentage change of BMI was calculated as (BMI in 2006 - BMI at baseline)/BMI at baseline, and was categorized into nine groups: decrease (≥ 15.0%, 10.0-14.9%, 5.0-9.9%, 2.5-4.9%), stable (decrease/increase < 2.5%), increase (2.5-4.9%, 5.0-9.9%, 10.0-14.9%, ≥ 15.0%). The associations between percentage change in BMI from study enrolment to follow-up (median: 9.1 years) and the risks of CRC and mortality were evaluated using Cox proportional hazard regression models. RESULTS:After 2006, there were 241 new CRC cases, 648 cancer-related deaths, and 2361 all-cause deaths identified. Overall, the associations between BMI change and CRC incidence and cancer-related mortality, respectively, were not statistically significant. Compared with participants whose BMI were stable, individuals who had a decrease in BMI were at increased risk of all-cause mortality, and the HRs were 1.21 (95% CI: 1.03-1.42), 1.65 (95% CI: 1.44-1.89), 1.84 (95% CI: 1.56-2.17), and 2.84 (95% CI: 2.42-3.35) for 2.5-4.9%, 5.0-9.9%, 10.0-14.9%, and ≥ 15.0% decrease in BMI, respectively. An L-shaped association between BMI change and all-cause mortality was observed. Every 5% decrease in BMI was associated with a 27% increase in the risk of all-cause mortality (HR = 1.27, 95% CI: 1.22-1.31, p < 0.001). The results from subgroups showed similar trends. CONCLUSIONS:A decrease in BMI more than 5% shows a significantly increased risk of all-cause mortality among older individuals; but no significant association between increase in BMI and all-cause mortality. These findings emphasize the importance of body weight management in older population, and more studies are warranted to evaluate the cause-and-effect relationship between changes in BMI and cancer incidence/mortality.Item Open Access Making Meaning through Music: How Older Adults’ Lifelong Experience with Music Creates Connections, Purpose, and Legacy(2024-04-29) Pawlak, AnikaThis project seeks to begin answering the question of how older adults perceive the way music has shaped their lives, experiences, and memories. Using an ethnographic approach, I interviewed nine current or previous residents of Croasdaile Village, a continuous care retirement community in Durham, North Carolina. Interviews were centered around themes of music across the lifespan, asking about origins of musicianship and music taste, experiences with music, and how these themes change during a lifetime. While initially, I wanted to gather first-person perspectives of how older adults view music's presence in their lives, being connected with many lifelong musicians quickly provided evidence that music is so much more than a soundtrack playing in the background. For my participants, music was, is, and will continue to be essential to who they are, the relationships they have, and the means by which they live their lives. The stories gathered in my interviews demonstrate the way interviewees organized their life narratives around music. This suggests that others might also do this. Through this means of storytelling, it became evident that for these folks, music provides purpose and dimension in life. Based on their narratives, it is clear my interlocutors believe that music is a lifelong experience that facilitates relationship building and meaning making in a way no other pursuit could. This interview project exposes and lifts up the importance of music as a mode of communication, connection and comfort across the lifespan.Item Open Access Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review.(GeroScience, 2024-03) Koh, Vanessa; Xuan, Lai Wei; Zhe, Tan Kai; Singh, Navrag; B Matchar, David; Chan, AngeliqueOlder adults with cognitive impairment (CI) are twice as likely to fall compared to the general older adult population. Traditional fall risk assessments may not be suitable for older adults with CI due to their reliance on attention and recall. Hence, there is an interest in using objective technology-based fall risk assessment tools to assess falls within this population. This systematic review aims to evaluate the features and performance of technology-based fall risk assessment tools for older adults with CI. A systematic search was conducted across several databases such as PubMed and IEEE Xplore, resulting in the inclusion of 22 studies. Most studies focused on participants with dementia. The technologies included sensors, mobile applications, motion capture, and virtual reality. Fall risk assessments were conducted in the community, laboratory, and institutional settings; with studies incorporating continuous monitoring of older adults in everyday environments. Studies used a combination of technology-based inputs of gait parameters, socio-demographic indicators, and clinical assessments. However, many missed the opportunity to include cognitive performance inputs as predictors to fall risk. The findings of this review support the use of technology-based fall risk assessment tools for older adults with CI. Further advancements incorporating cognitive measures and additional longitudinal studies are needed to improve the effectiveness and clinical applications of these assessment tools. Additional work is also required to compare the performance of existing methods for fall risk assessment, technology-based fall risk assessments, and the combination of these approaches.Item Embargo Predicting All-cause Mortality among Chinese Community-Dwelling Elderly(2020) Jin, XuruiBackground and aim: This study aimed at building the prediction model of all-cause mortality among Chinese dwelling elderly with different methods including regression models and machine learning models and to compare the performance of machine learning models with regression models on predicting mortality. Additionally, this study also aimed at ranking the predictors of mortality within different models and comparing the predictive value of different groups of predictors using the model with the best performance.Method: I used data from the Healthy Ageing and Biomarkers Cohort Study, a sub-study of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). The baseline survey was conducted in 2008 and participants were followed every 2-3 years till 2018. The analysis sample included 2,448 participants. I used totally 117 predictors to build the prediction model, including 65 questionnaires, 39 biomarkers, and 15 genetics predictors. Four models were built (XG-Boost, random survival forest [RSF], Cox regression with all variables, and Cox-backward). I used C-index and integrated Brier score to evaluate the performance of those four models. Results: The XG-Boost model and RSF model shows slightly better predictive performance than Cox models and Cox-backward models based on the C-index and integrated Brier score. Age. The activity of daily living and Mini-Mental State Examination score were identified as the top 3 predictors in the XG-Boost and RSF models. Biomarker and questionnaire predictors have a similar predictive value, while genetic predictors have no addictive predictive value when combined with questionnaire or biomarker predictors. Conclusion: In this work, it is shown that machine learning techniques can be a useful tool for both prediction and its performance sightly outperformed the regression model in predicting survival.
Item Open Access Relationship between neural functional connectivity and memory performance in age-related macular degeneration.(Neurobiology of aging, 2020-11) Zuo, Xintong; Zhuang, Jie; Chen, Nan-Kuei; Cousins, Scott; Cunha, Priscila; Lad, Eleonora M; Madden, David J; Potter, Guy; Whitson, Heather EAge-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysis to quantify the strength of functional connectivity between hubs of the default mode network and a network of medial temporal regions relevant for memory. Our results indicated neither memory performance nor network connectivity differed by AMD status. However, the AMD participants exhibited stronger relationships than the controls between memory performance and connectivity from the memory network hub (left parahippocampal) to 2 other regions: the left temporal pole and the right superior/middle frontal gyri. Also, the connectivity between the medial prefrontal cortex and posterior cingulate cortex of default mode network correlated more strongly with memory performance in AMD compared to control. We concluded that stronger brain-behavior correlation in AMD may suggest a role for region-specific connectivity in supporting memory in the context of AMD.Item Open Access Self-Regulation before and after a Developmental Transition: a Study of Adaptive Goal Change in Retirement(2008-08-08) Aspnes, AnnRetirement is the quintessential transition from mid-life to late-life for many working Americans. However, questions about the positive and negative effects of retirement have sparked widely divergent empirical findings. Developmental theories of self-regulation may add to the understanding of the subtle differences and transitions within retirement. Retirement may be viewed as a transition in resources (e.g., psychological, social, and financial), so that individual mental health outcomes are linked to how well these resources are reallocated. According to goal disengagement perspectives, failure either in disengagement from past goals or reengagement in new goals can lead to decreased well-being and increased depression. Further, as individuals enter late-life, their focus may turn away from growth and achievement and more toward preventing losses and maintaining current resources. In the present study, it was hypothesized that when pre-retirement individuals were compared against early and late post-retirement individuals, engagement in developmentally relevant goals (e.g., self, family, and leisure) in retirees would be associated with better mental health outcomes while retirees who reported continued engagement in less developmentally accessible goals (i.e., occupational and financial) would report worse outcomes.
A total of 100 study participants (aged 50 to 84) were interviewed about their current goals and completed self-report measures of depression, well-being, social support, physical health, and regulatory focus. Interview data were coded for goal content as well as for regulatory focus. Findings did not support the hypotheses, as there were no significant differences among the 47 pre-retirement, 29 early post-retirement, and 24 late post-retirement participants in their goal content or regulatory focus. Goal content also was not associated differentially with depression or well-being among the three groups. However, the interview data did provide valuable information about the heterogeneous and fluid nature of retirement. Retirement, rather than a clear loss in certain resources (i.e., financial and occupational) and a clear gain in others (i.e., time and personal freedom), seemed to be a renegotiation of those resources. Furthermore, even pre-retirement participants named retirement goals, suggesting that, if a goal transition did occur, it may have been a more conscious, gradual process.
Item Open Access Stable ischemic heart disease in the older adults.(J Geriatr Cardiol, 2016-02) Dai, Xuming; Busby-Whitehead, Jan; Forman, Daniel E; Alexander, Karen PItem Open Access The impact of residential status on cognitive decline among older adults in China: Results from a longitudinal study.(BMC Geriatr, 2017-05-15) Xu, Hanzhang; Dupre, Matthew E; Gu, Danan; Wu, BeiBACKGROUND: Residential status has been linked to numerous determinants of health and well-being. However, the influence of residential status on cognitive decline remains unclear. The purpose of this research was to assess the changes of cognitive function among older adults with different residential status (urban residents, rural-to-urban residents, rural residents, and urban-to-rural residents), over a 12-year period. METHODS: We used five waves of data (2002, 2005, 2008/2009, 2011/2012, and 2014) from the Chinese Longitudinal Healthy Longevity Survey with 17,333 older adults age 65 and over who were interviewed up to five times. Cognitive function was measured by the Mini Mental State Examination (MMSE). Multilevel models were used regarding the effects of residential status after adjusting for demographic characteristics, socioeconomic factors, family support, health behaviors, and health status. RESULTS: After controlling for covariates, significant differences in cognitive function were found across the four groups: rural-to-urban and rural residents had a higher level of cognition than urban residents at baseline. On average, cognitive function decreased over the course of the study period. Rural-to-urban and rural residents demonstrated a faster decline in cognitive function than urban residents. CONCLUSIONS: This study suggests that residential status has an impact on the rate of changes in cognition among older adults in China. Results from this study provide directions for future research that addresses health disparities, particularly in countries that are undergoing significant socioeconomic transitions.Item Open Access The Manual Therapy and Strengthening for the Hip (MASH) Trial: Protocol for a Multisite Randomized Trial of a Subgroup of Older Adults with Chronic Back and Hip Pain.(Physical therapy, 2021-11-08) Pugliese, Jenifer M; Coyle, Peter C; Knox, Patrick J; Sions, J Megan; Patterson, Charity G; Pohlig, Ryan T; Simon, Corey B; Weiner, Debra K; George, Steven Z; Piva, Sara; Hicks, Gregory EObjective
Chronic low back pain (CLBP) is a disabling and costly condition for older adults that is difficult to properly classify and treat. In a cohort study, a subgroup of older adults with CLBP who had elevated hip pain and hip muscle weakness was identified; this subgroup differentiated itself by being at higher risk for future mobility decline. The primary purpose of this clinical trial is to evaluate whether a hip-focused low back pain (LBP) treatment provides better disability and physical performance outcomes for this at-risk group when compared to a spine-focused LBP treatment.Methods
This study is a multisite, single-blinded, randomized controlled, parallel arm, Phase II trial conducted across 3 clinical research sites. A total of 180 people between 60 and 85 years of age with CLBP and hip pain are being recruited. Participants undergo a comprehensive baseline assessment and are randomized into 1 of 2 intervention arms: hip-focused or spine-focused. They are treated twice weekly by a licensed physical therapist for 8 weeks and undergo follow-up assessments at 8 weeks and 6 months after randomization. Primary outcome measures include the Quebec Low Back Disability Scale and the 10-Meter Walk Test, which are measures of self-report and performance-based physical function, respectively.Impact
This multicenter, randomized clinical trial will determine whether a hip-focused or spine-focused physical therapist intervention results in improved disability and physical performance for a subgroup of older adults with CLBP and hip pain who are at increased risk of mobility decline. This trial will help further the development of effective interventions for this subgroup of older adults with CLBP.Item Open Access The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study.(Pilot and feasibility studies, 2022-03) Oyedeji, Charity I; Hall, Katherine; Luciano, Alison; Morey, Miriam C; Strouse, John JBackground
The life expectancy for individuals with sickle cell disease (SCD) has greatly increased over the last 50 years. Adults with SCD experience multiple complications such as cardiopulmonary disease, strokes, and avascular necrosis that lead to limitations that geriatric populations often experience. There are no dedicated instruments to measure functional decline and functional age to determine risk of future adverse outcomes in older adults with SCD. The objective of this study was to assess the feasibility of performing the Sickle Cell Disease Functional Assessment (SCD-FA).Methods
We enrolled 40 adults with SCD (20 younger adults aged 18-49 years as a comparison group and 20 older adults aged 50 years and older) in a single-center prospective cohort study. Participants were recruited from a comprehensive sickle cell clinic in an academic center in the southeastern United States. We included measures validated in an oncology geriatric assessment enriched with additional physical performance measures: usual gait speed, seated grip strength, Timed Up and Go, six-minute walk test, and 30-second chair stand. We also included an additional cognitive measure, which was the Montreal Cognitive Assessment, and additional patient-reported measures at the intersection of sickle cell disease and geriatrics. The primary outcome was the proportion completing the assessment. Secondary outcomes were the proportion consenting, duration of the assessment, acceptability, and adverse events.Results
Eighty percent (44/55) of individuals approached consented, 91% (40/44) completed the SCD-FA in its entirety, and the median duration was 89 min (IQR 80-98). There were no identified adverse events. On the acceptability survey, 95% (38/40) reported the length as appropriate, 2.5% (1/40) reported a question as upsetting, and 5% (2/40) reported portions as difficult. Exploratory analyses of physical function showed 63% (25/40) had a slow usual gait speed (< 1.2 m/s).Conclusion
The SCD-FA is feasible, acceptable, and safe and physical performance tests identified functional impairments in adults with SCD. These findings will inform the next phase of the study where we will assess the validity of the SCD-FA to predict patient-important outcomes in a larger sample of adults with SCD.Item Open Access Urban-rural differences in the association between access to healthcare and health outcomes among older adults in China.(BMC Geriatr, 2017-07-19) Zhang, Xufan; Dupre, Matthew E; Qiu, Li; Zhou, Wei; Zhao, Yuan; Gu, DananBACKGROUND: Studies have shown that inadequate access to healthcare is associated with lower levels of health and well-being in older adults. Studies have also shown significant urban-rural differences in access to healthcare in developing countries such as China. However, there is limited evidence of whether the association between access to healthcare and health outcomes differs by urban-rural residence at older ages in China. METHODS: Four waves of data (2005, 2008/2009, 2011/2012, and 2014) from the largest national longitudinal survey of adults aged 65 and older in mainland China (n = 26,604) were used for analysis. The association between inadequate access to healthcare (y/n) and multiple health outcomes were examined-including instrumental activities of daily living (IADL) disability, ADL disability, cognitive impairment, and all-cause mortality. A series of multivariate models were used to obtain robust estimates and to account for various covariates associated with access to healthcare and/or health outcomes. All models were stratified by urban-rural residence. RESULTS: Inadequate access to healthcare was significantly higher among older adults in rural areas than in urban areas (9.1% vs. 5.4%; p < 0.01). Results from multivariate models showed that inadequate access to healthcare was associated with significantly higher odds of IADL disability in older adults living in urban areas (odds ratio [OR] = 1.58-1.79) and rural areas (OR = 1.95-2.30) relative to their counterparts with adequate access to healthcare. In terms of ADL disability, we found significant increases in the odds of disability among rural older adults (OR = 1.89-3.05) but not among urban older adults. Inadequate access to healthcare was also associated with substantially higher odds of cognitive impairment in older adults from rural areas (OR = 2.37-3.19) compared with those in rural areas with adequate access to healthcare; however, no significant differences in cognitive impairment were found among older adults in urban areas. Finally, we found that inadequate access to healthcare increased overall mortality risks in older adults by 33-37% in urban areas and 28-29% in rural areas. However, the increased risk of mortality in urban areas was not significant after taking into account health behaviors and baseline health status. CONCLUSIONS: Inadequate access to healthcare was significantly associated with higher rates of disability, cognitive impairment, and all-cause mortality among older adults in China. The associations between access to healthcare and health outcomes were generally stronger among older adults in rural areas than in urban areas. Our findings underscore the importance of providing adequate access to healthcare for older adults-particularly for those living in rural areas in developing countries such as China.