Browsing by Subject "POPULATION"

Now showing 1 - 8 of 8
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    Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.
    (Blood cancer journal, 2019-08-05) Clay-Gilmour, Alyssa I; Rishi, Abdul R; Goldin, Lynn R; Greenberg-Worisek, Alexandra J; Achenbach, Sara J; Rabe, Kari G; Maurer, Matthew J; Kay, Neil E; Shanafelt, Tait D; Call, Timothy G; Brice Weinberg, J; Camp, Nicola J; Cerhan, James R; Leis, Jose; Norman, Aaron; Murray, David L; Vincent Rajkumar, S; Caporaso, Neil E; Landgren, Ola; McMaster, Mary L; Slager, Susan L; Vachon, Celine M
    Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differences between sFLC measurements in pre-treatment serum from five groups to inform the association of sFLC with familial and sporadic CLL: (1) familial CLL (n = 154), (2) sporadic CLL (n = 302), (3) familial MBL (n = 87), (4) unaffected first-degree relatives from CLL/MBL families (n = 263), and (5) reference population (n = 15,396). The percent of individuals having elevated monoclonal and polyclonal sFLCs was compared using age-stratified and age- and sex-adjusted logistic regression models. In age groups >50 years, monoclonal sFLC elevations were increased in sporadic and familial CLL cases compared to the reference population (p's < 0.05). However, there were no statistically significant differences in sFLC monoclonal or polyclonal elevations between familial and sporadic CLL cases (p's > 0.05). Unaffected relatives and MBL cases from CLL/MBL families, ages >60 years, showed elevated monoclonal sFLC, compared to the reference population (p's < 0.05). This is the first study to demonstrate monoclonal sFLC elevations in CLL cases compared to controls. Monoclonal sFLC levels may provide additional risk information in relatives of CLL probands.
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    Depression, quality of life, and medical resource utilization in sickle cell disease.
    (Blood advances, 2017-10-12) Adam, Soheir S; Flahiff, Charlene M; Kamble, Shital; Telen, Marilyn J; Reed, Shelby D; De Castro, Laura M
    Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with SCD and its association with HRQoL and medical resource utilization. Depression was measured by the Beck Depression Inventory and clinical history in adult SCD outpatients at a comprehensive SCD center. HRQoL was assessed using the SF36 form, and data were collected on medical resource utilization and corresponding cost. Neurocognitive functions were assessed using the CNS Vital Signs tool. Pain diaries were used to record daily pain. Out of 142 enrolled patients, 42 (35.2%) had depression. Depression was associated with worse physical and mental HRQoL scores (P < .0001 and P < .0001, respectively). Mean total inpatient costs ($25 000 vs $7487, P = .02) and total health care costs ($30 665 vs $13 016, P = .01) were significantly higher in patients with depression during the 12 months preceding diagnosis. Similarly, during the 6 months following diagnosis, mean total health care costs were significantly higher in depressed patients than in nondepressed patients ($13 766 vs $8670, P = .04). Depression is prevalent in adult patients with SCD and is associated with worse HRQoL and higher total health care costs. Efforts should focus on prevention, early diagnosis, and therapy for depression in SCD.
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    Reflections on sea turtle conservation
    (Oryx, 2020-05) Godley, BJ; Broderick, AC; Colman, LP; Formia, A; Godfrey, MH; Hamann, M; Nuno, A; Omeyer, LCM; Patrício, AR; Phillott, AD; Rees, AF; Shanker, K
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    The Emergence of Organizational Forms: A Community Ecology Approach
    (American Journal of Sociology, 2000) Ruef, M
    This article introduces a new ecological approach to the study of form emergence based on the notion of an organizational community - a bounded set of forms with related identities. Applying the approach to 48 organizational forms in the health care sector, this study suggests that the development of novel forms is affected by the positioning of their identities with respect to existing form identities in the community, by the aggregate density and size of organizations matching those existing identities, and by the amount of attention directed at identity attributes by sector participants. Findings show that the process of form emergence is subject to population-dependent effects akin to those noted previously for organizational entries within established populations. The aggregate density and size of organizations with similar identities increase the probability of form emergence to a point (cross-form legitimation), but highly saturated regions of the identity space tend to be uninviting to new forms (cross-form competition).
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    The Historical Demography of Racial Segregation
    (American Sociological Review, 2015) Grigoryeva, A; Ruef, M
    Standard measures of residential segregation tend to equate spatial with social proximity. This assumption has been increasingly subject to critique among demographers and ethnographers and becomes especially problematic in historical settings. In the late nineteenth-century United States, standard measures suggest a counterintuitive pattern: southern cities, with their long history of racial inequality, had less residential segregation than urban areas considered to be more racially tolerant. By using census enumeration procedures, we develop a sequence measure that captures a more subtle “backyard” pattern of segregation, where white families dominated front streets and blacks were relegated to alleys. Our analysis of complete household data from the 1880 Census documents how segregation took various forms across the postbellum United States. Whereas northern cities developed segregation via racialized neighborhoods, substituting residential inequality for the status inequality of slavery, southern cities embraced street-front segregation that reproduced the racial inequality that existed under slavery.
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    The paraphyly of Osmunda is confirmed by phylogenetic analyses of seven plastid loci
    (Systematic Botany, 2008-03-01) Metzgar, JS; Skog, JE; Zimmer, EA; Pryer, KM
    To resolve phylogenetic relationships among all genera and subgenera in Osmundaceae, we analyzed over 8,500 characters of DNA sequence data from seven plastid loci (atpA, rbcL, rbcL-accD, rbcL-atpB, rps4-trnS, trnG-trnR, and trnL-trnF). Our results confirm those from earlier anatomical and single-gene (rbcL) studies that suggested Osmunda s.l. is paraphyletic. Osmunda cinnamomea is sister to the remainder of Osmundaceae (Leptopteris, Todea, and Osmunda s.s.). We support the recognition of a monotypic fourth genus, Osmundastrum, to reflect these results. We also resolve subgeneric relationships within Osmunda s.s. and find that subg. Claytosmunda is strongly supported as sister to the rest of Osmunda. A stable, well-supported classification for extant Osmundaceae is proposed, along with a key to all genera and subgenera. © Copyright 2008 by the American Society of Plant Taxonomists.
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    The size of savannah Africa: A lion's (Panthera leo) view
    (Biodiversity and Conservation, 2013-01-01) Riggio, Jason; Jacobson, Andrew; Dollar, Luke; Bauer, Hans; Becker, Matt; Dickman, Amy; Funston, Paul; Groom, Rosemary; Henschel, Philipp; de Iongh, Hans; Lichtenfeld, Laly; Pimm, Stuart
    We define African savannahs as being those areas that receive between 300 and 1,500 mm of rain annually. This broad definition encompasses a variety of habitats. Thus defined, savannahs comprise 13.5 million km2 and encompass most of the present range of the African lion (Panthera leo). Dense human populations and extensive conversion of land to human use preclude use by lions. Using high-resolution satellite imagery and human population density data we define lion areas, places that likely have resident lion populations. In 1960, 11.9 million km2 of these savannahs had fewer than 25 people per km2. The comparable area shrank to 9.7 million km2 by 2000. Areas of savannah Africa with few people have shrunk considerably in the last 50 years and human population projections suggest they will likely shrink significantly in the next 40. The current extent of free-ranging lion populations is 3.4 million km2 or about 25 % of savannah area. Habitats across this area are fragmented; all available data indicate that between 32,000 and 35,000 free-ranging lions live in 67 lion areas. Although these numbers are similar to previous estimates, they are geographically more comprehensive. There is abundant evidence of widespread declines and local extinctions. Under the criteria we outline, ten lion areas qualify as lion strongholds: four in East Africa and six in Southern Africa. Approximately 24,000 lions are in strongholds, with an additional 4,000 in potential ones. However, over 6,000 lions are in populations of doubtful long-term viability. Lion populations in West and Central Africa are acutely threatened with many recent, local extinctions even in nominally protected areas. © 2012 The Author(s).
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    Trajectories of functional ability over the life course: a conceptual model of the interaction of stressor-induced functional loss and resilience.
    (System dynamics review, 2018-10) Matchar, David B; Ansah, John P; Koh, Victoria; Whitson, Heather E
    Understanding the factors that influence functional ability over the life course is integral to identifying clinical and public health policies to facilitate successful aging. The World Health Organization has advocated a conceptual framework to clarify the policy discussion. We have sought to translate this general framework into an explicit system dynamics model of the interaction of physiological loss, stressors and endogenous responses to produce a familiar variety of trajectories of functional ability over the life courses. Simulation experiments were implemented for both a 30-month duration with only one major stressor; and for the life course with an initial major stressor and subsequent stressors determined by the level of functional ability. For both contexts, variations in the few parameters in the scenarios led to a realistic range of trajectories of function over time.