Browsing by Subject "Tobacco"
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Item Open Access A Lysine Residue Essential for Geminivirus Replication Also Controls Nuclear Localization of the Tomato Yellow Leaf Curl Virus Rep Protein.(Journal of virology, 2019-05) Maio, Francesca; Arroyo-Mateos, Manuel; Bobay, Benjamin G; Bejarano, Eduardo R; Prins, Marcel; van den Burg, Harrold AGeminiviruses are single-stranded DNA (ssDNA) viruses that infect a wide range of plants. To promote viral replication, geminiviruses manipulate the host cell cycle. The viral protein Rep is essential to reprogram the cell cycle and then initiate viral DNA replication by interacting with a plethora of nuclear host factors. Even though many protein domains of Rep have been characterized, little is known about its nuclear targeting. Here, we show that one conserved lysine in the N-terminal part of Rep is pivotal for nuclear localization of the Rep protein from Tomato yellow leaf curl virus (TYLCV), with two other lysines also contributing to its nuclear import. Previous work had identified that these residues are essential for Rep from Tomato golden mosaic virus (TGMV) to interact with the E2 SUMO-conjugating enzyme (SCE1). We here show that mutating these lysines leads to nuclear exclusion of TYLCV Rep without compromising its interaction with SCE1. Moreover, the ability of TYLCV Rep to promote viral DNA replication also depends on this highly conserved lysine independently of its role in nuclear import of Rep. Our data thus reveal that this lysine potentially has a broad role in geminivirus replication, but its role in nuclear import and SCE1 binding differs depending on the Rep protein examined.IMPORTANCE Nuclear activity of the replication initiator protein (Rep) of geminiviruses is essential for viral replication. We now define that one highly conserved lysine is important for nuclear import of Rep from three different begomoviruses. To our knowledge, this is the first time that nuclear localization has been mapped for any geminiviral Rep protein. Our data add another key function to this lysine residue, besides its roles in viral DNA replication and interaction with host factors, such as the SUMO E2-conjugating enzyme.Item Open Access A Pilot Tobacco Intervention Study in Palau, Micronesia(2018) Sun, AnliTobacco has been recognized as a serious public health issue that threatens people’s health in Palau, Micronesia, especially as young people consume tobacco in multiple ways. The research of this thesis begins with a description of the complex mix of habits, social norms, history, and cultural practice that make up tobacco use in Palau. Then an intervention project using “journaling behavior change paradigm” among young adults based on their own reflections on tobacco use by writing journals, is described. A high prevalence of tobacco use in all forms was revealed in this study, among which chew betel nuts with tobacco is the most popular method. Friend and family members’ attitude play important roles in affecting people’s tobacco use. Also, the evaluation of journaling paradigm reveals potential in lowering tobacco consumption in Palau and other countries by raising awareness of the problem through the writing of journals and diaries.
Item Open Access Alcohol, drugs, caffeine, tobacco, and environmental contaminant exposure: reproductive health consequences and clinical implications.(Critical reviews in toxicology, 2010-08) Sadeu, JC; Hughes, Claude L; Agarwal, Sanjay; Foster, Warren GReproductive function and fertility are thought to be compromised by behaviors such as cigarette smoking, substance abuse, and alcohol consumption; however, the strength of these associations are uncertain. Furthermore, the reproductive system is thought to be under attack from exposure to environmental contaminants, particularly those chemicals shown to affect endocrine homeostasis. The relationship between exposure to environmental contaminants and adverse effects on human reproductive health are frequently debated in the scientific literature and these controversies have spread into the lay press drawing increased public and regulatory attention. Therefore, the objective of the present review was to critically evaluate the literature concerning the relationship between lifestyle exposures and adverse effects on fertility as well as examining the evidence for a role of environmental contaminants in the purported decline of semen quality and the pathophysiology of subfertility, polycystic ovarian syndrome, and endometriosis. The authors conclude that whereas cigarette smoking is strongly associated with adverse reproductive outcomes, high-level exposures to other lifestyle factors are only weakly linked with negative fertility impacts. Finally, there is no compelling evidence that environmental contaminants, at concentrations representative of the levels measured in contemporary biomonitoring studies, have any effect, positive or negative, on reproductive health in the general population. Further research using prospective study designs with robust sample sizes are needed to evaluate testable hypotheses that address the relationship between exposure and adverse reproductive health effects.Item Open Access An examination of neurocognition and theory of mind as predictors of engagement with a tailored digital therapeutic in persons with serious mental illness.(Schizophrenia research. Cognition, 2022-06) Halverson, Tate F; Browne, Julia; Thomas, Samantha M; Palenski, Paige; Vilardaga, RogerThere is an increasing interest in the development and implementation of digital therapeutics (apps) in individuals with serious mental illness (SMI). However, there is limited understanding of the role of neurocognition and social cognition on engagement with apps. The present study is a secondary analysis of a pilot randomized controlled trial (N = 62) comparing a tailored digital intervention to treat tobacco use disorder in individuals with SMI to a standard of care digital intervention for the general population. The purpose of this study was to examine the impact of neurocognition, social cognition, and clinical characteristics on indices of app engagement in users of the tailored app compared to users of the standard of care app. Correlational analyses demonstrated that individuals with low levels of neurocognition and social cognition engaged more often and for longer duration with the tailored app compared to the standard of care app. In a series of multilevel zero-inflated negative binomial models, assignment to the tailored app remained the most robust predictor of app interactions (Risk Ratio [RR] = 1.72; p < .01), duration of app use (RR = 6.47; p < .01), and average length of interaction (RR = 2.70; p < .01), after adjusting for key demographic and clinical characteristics, and two measures of cognition. This is one of the first studies to demonstrate that digital therapeutics can be designed to mitigate the impact of neurocognition and social cognition on device engagement in SMI populations. Recommendations are made to advance the use of new analytic models to uncover patterns of engagement with digital therapeutics.Item Open Access Associations of Alcohol and Tobacco Retail Outlet Rates with Neighborhood Disadvantage.(International journal of environmental research and public health, 2022-01-20) Wheeler, David C; Boyle, Joseph; Barsell, D Jeremy; Glasgow, Trevin; McClernon, F Joseph; Oliver, Jason A; Fuemmeler, Bernard FTobacco causes 29% of cancer-related deaths while alcohol causes 5.5% of cancer-related deaths. Reducing the consumption of these cancer-causing products is a special priority area for the National Cancer Institute. While many factors are linked to tobacco and alcohol use, the placement and density of retail outlets within neighborhoods may be one community-level risk factor contributing to greater use of these products. To elucidate associations between tobacco, alcohol, and tobacco and alcohol retail outlets (TRO, ARO, and TARO) and neighborhood disadvantage over a large geographic area, we employed a novel Bayesian index modeling approach to estimate a neighborhood disadvantage index (NDI) and its associations with rates of the three types of retailers across block groups in the state of North Carolina. We used a novel extension of the Bayesian index model to include a shared component for the spatial pattern common to all three types of outlets and NDI effects that varied by outlet type. The shared component identifies areas that are elevated in risk for all outlets. The results showed significant positive associations between neighborhood disadvantage and TROs (relative risk (RR) = 1.12, 95% credible interval (CI = 1.09, 1.14)) and AROs (RR = 1.15, 95% CI = 1.11, 1.17), but the association was greatest for TAROs (RR = 1.21, 95% CI = 1.18, 1.24). The most important variables in the NDI were percent renters (i.e., low home ownership), percent of homes built before 1940 (i.e., old housing stock), and percent without a high school diploma (i.e., low education).Item Open Access Causes and Impacts of Institutional and Structural Variation: Globalization in the Tobacco and Pork Industries(2010) Denniston, RyanAmong the most significant changes to the agricultural sector in the twentieth century include a sharp decline in employment and the numbers of farms, a decline in the proportion of total value that accrues to agricultural producers, and an increase in farm level and regional specialization. Within the U.S., substantial differences in the characteristics of agricultural producers and the spatial distribution of production persist amid industry change. These changes coincided with changes in global markets, domestic consumption, consolidation and concentration within the processing and retailing sectors, and government policy. The causality that lies behind these developments is the key puzzle that this study addresses.
This study advances an institutional explanation of industry formation across locations within the U.S. Differences in industry constitution at the local level produce different impacts of and responses to global markets, reflected by economic changes and policy developments, as actors work to secure stability and advantage in markets (Fligstein 2001). This study uses the global value chains' definition of the industry, which incorporates the network of actors arrayed along a process of production, to capture the set of actors with the capacity to affect industry operation (Gereffi 1994). An assessment of the relative importance of local economic characteristics, global markets, organization and coordination within industries, and government policies to where production locates in the primary objective of the study.
The pork and non-cigar tobacco industries across several states within the United States from 1959 through 2005 allow for a contrast along the key changes identified above. Within case comparison is used to construct causal narratives of industry change at the state level. Panel and pooled time series analysis assess the relative importance the factors to agricultural change.
Local economic characteristics largely fade from significance with the inclusion of the theoretical perspectives. Total and net trade in agricultural and manufactured products is generally significant across industries for production, although this is not the case for specific tobacco types. The proportion of farms composed of small farms is significant for production and for farm structure in both industries. The presence of manufacture is significant for hog production and could not be assessed for tobacco. While federal policies are broadly significant for the tobacco industry, identified state policies exhibit few consistent effects for hog production. Importantly, farm structure measures were only available for Census years, which reduces sample size. Second, many of the measures are industry-specific, which reduces comparability.
Item Open Access Incentivizing Healthy Behavior in State Employees Through Wellness Programs(2015-05-01) Hendrix, LizOver the past ten years, states have increasingly started to implement wellness programs for state employees as a way to curb rising healthcare costs and the growing prevalence of chronic conditions. Many states are offering incentives as part of their wellness programs to motivate healthier behaviors and improve overall health outcomes for state employees. This Master’s Project examines the different types of incentives and disincentives that states are providing through wellness programs and considers the effects that these programs may be having on state employee health and wellness.Item Open Access Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure?(Toxicological sciences : an official journal of the Society of Toxicology, 2017-01) Slotkin, Theodore A; Stadler, Ashley; Skavicus, Samantha; Card, Jennifer; Ruff, Jonathan; Levin, Edward D; Seidler, Frederic JSecondhand tobacco smoke exposure in pregnancy increases the risk of neurodevelopmental disorders. We evaluated in rats whether there is a critical period during which tobacco smoke extract (TSE) affects the development of acetylcholine and serotonin systems, prominent targets for adverse effects of nicotine and tobacco smoke. We simulated secondhand smoke exposure by administering TSE so as to produce nicotine concentrations one-tenth those in active smoking, with 3 distinct, 10-day windows: premating, early gestation or late gestation. We conducted longitudinal evaluations in multiple brain regions, starting in early adolescence (postnatal day 30) and continued to full adulthood (day 150). TSE exposure in any of the 3 windows impaired presynaptic cholinergic activity, exacerbated by a decrement in nicotinic cholinergic receptor concentrations. Although the adverse effects were seen for all 3 treatment windows, there was a distinct progression, with lowest sensitivity for premating exposure and higher sensitivity for gestational exposures. Serotonin receptors were also reduced by TSE exposure with the same profile: little effect with premating exposure, intermediate effect with early gestational exposure and large effect with late gestational exposure. As serotonergic circuits can offset the neurobehavioral impact of cholinergic deficits, these receptor changes were maladaptive. Thus, there is no single 'critical period' for effects of low-level tobacco smoke but there is differential sensitivity dependent upon the developmental stage at the time of exposure. Our findings reinforce the need to avoid secondhand smoke exposure not only during pregnancy, but also in the period prior to conception, or generally for women of childbearing age.Item Open Access Localization of DIR1 at the tissue, cellular and subcellular levels during Systemic Acquired Resistance in Arabidopsis using DIR1:GUS and DIR1:EGFP reporters.(BMC plant biology, 2011-01) Champigny, Marc J; Shearer, Heather; Mohammad, Asif; Haines, Karen; Neumann, Melody; Thilmony, Roger; He, Sheng Yang; Fobert, Pierre; Dengler, Nancy; Cameron, Robin KBACKGROUND: Systemic Acquired Resistance (SAR) is an induced resistance response to pathogens, characterized by the translocation of a long-distance signal from induced leaves to distant tissues to prime them for increased resistance to future infection. DEFECTIVE in INDUCED RESISTANCE 1 (DIR1) has been hypothesized to chaperone a small signaling molecule to distant tissues during SAR in Arabidopsis. RESULTS: DIR1 promoter:DIR1-GUS/dir1-1 lines were constructed to examine DIR1 expression. DIR1 is expressed in seedlings, flowers and ubiquitously in untreated or mock-inoculated mature leaf cells, including phloem sieve elements and companion cells. Inoculation of leaves with SAR-inducing avirulent or virulent Pseudomonas syringae pv tomato (Pst) resulted in Type III Secretion System-dependent suppression of DIR1 expression in leaf cells. Transient expression of fluorescent fusion proteins in tobacco and intercellular washing fluid experiments indicated that DIR1's ER signal sequence targets it for secretion to the cell wall. However, DIR1 expressed without a signal sequence rescued the dir1-1 SAR defect, suggesting that a cytosolic pool of DIR1 is important for the SAR response. CONCLUSIONS: Although expression of DIR1 decreases during SAR induction, the protein localizes to all living cell types of the vasculature, including companion cells and sieve elements, and therefore DIR1 is well situated to participate in long-distance signaling during SAR.Item Open Access Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.(Ann Epidemiol, 2015-08) Pedersen, Jacob K; Skytthe, Axel; McGue, Matt; Honig, Lawrence S; Franceschi, Claudio; Kirkwood, Thomas BL; Passarino, Giuseppe; Slagboom, P Eline; Vaupel, James W; Christensen, KaarePURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific cancers is a mechanism for familial clustering of longevity. METHODS: The study population of individuals from longevity-enriched families consisted of 3267 offspring from 610 Danish long-lived families defined by two siblings attaining an age of 90 years or more. The offspring of the long-lived siblings were followed from 1968 to 2009. Using high-quality registry data, observed numbers of cancers were compared with expected numbers based on gender-, calendar period-, and age-specific incidence rates in the general population. RESULTS: During the 41-year-follow-up period, a total of 423 cancers occurred in 397 individuals. The standardized incidence ratios (95% confidence interval) for offspring of long-lived individuals were 0.78 (0.70-0.86) for overall cancer; 0.66 (0.56-0.77) for tobacco-related cancer; 0.34 (0.22-0.51) for lung cancer; 0.88 (0.71-1.10) for breast cancer; 0.91 (0.62-1.34) for colon cancer. CONCLUSIONS: The low incidence of tobacco-related cancers in long-lived families compared with non-tobacco-related cancers suggests that health behavior plays a central role in lower early cancer incidence in offspring of long-lived siblings in Denmark.Item Open Access Mindfulness training for smokers via web-based video instruction with phone support: a prospective observational study.(BMC complementary and alternative medicine, 2015-03-29) Davis, James M; Manley, Alison R; Goldberg, Simon B; Stankevitz, Kristin A; Smith, Stevens SBACKGROUND:Many smokers are unable to access effective behavioral smoking cessation therapies due to location, financial limitations, schedule, transportation issues or other reasons. We report results from a prospective observational study in which a promising novel behavioral intervention, Mindfulness Training for Smokers was provided via web-based video instruction with telephone-based counseling support. METHODS:Data were collected on 26 low socioeconomic status smokers. Participants were asked to watch eight video-based classes describing mindfulness skills and how to use these skills to overcome various core challenges in tobacco dependence. Participants received eight weekly phone calls from a smoking cessation coach who provided general support and answered questions about the videos. On the quit day, participants received two weeks of nicotine patches. RESULTS:Participants were a mean of 40.5 years of age, smoked 16.31 cigarettes per day for 21.88 years, with a mean of 6.81 prior failed quit attempts. Participants completed a mean of 5.55 of 8 online video classes with a mean of 23.33 minutes per login, completed a mean of 3.19 of 8 phone coach calls, and reported a mean meditation practice time of 12.17 minutes per day. Smoking abstinence was defined as self-reported abstinence on a smoking calendar with biochemical confirmation via carbon monoxide breath-test under 7 parts per million. Intent-to-treat analysis demonstrated 7-day point prevalence smoking abstinence at 4 and 6-months post-quit of 23.1% and 15.4% respectively. Participants showed a significant pre- to post-intervention increase in mindfulness as measured by the Five-Factor Mindfulness Questionnaire, and a significant pre- to post-intervention decrease in the Anxiety Sub-scale of the Depression Anxiety and Stress Scale. CONCLUSIONS:Results suggest that Mindfulness Training for Smokers can be provided via web-based video instruction with phone support and yield reasonable participant engagement on intervention practices and that intervention efficacy and mechanism of effect deserve further study. TRIAL REGISTRATION:ClinicalTrials.gov: NCT02164656 , Registration Date June 13, 2014.Item Open Access Native Hawaiian/Pacific Islander alcohol, tobacco and other drug use, mental health and treatment need in the United States during COVID-19.(Drug and alcohol review, 2022-11) Subica, Andrew M; Guerrero, Erick G; Martin, Tammy KK; Okamoto, Scott K; Aitaoto, Nia; Moss, Howard B; Morey, Brittany N; Wu, Li-TzyIntroduction
Before COVID-19, Native Hawaiians/Pacific Islanders (NH/PI) endured a heavy burden of alcohol, tobacco and other drug (ATOD) use in prior US data. Responding to reports that many NH/PI communities experienced severe COVID-19 disparities that could exacerbate their ATOD burden, we partnered with NH/PI communities to assess the substance use patterns and treatment needs of diverse NH/PIs during COVID-19.Methods
Collaborating with NH/PI community organisations across five states with large NH/PI populations, we conducted a large-scale investigation of NH/PI ATOD use, mental health and treatment need during COVID-19. Between April and November 2021, NH/PI-heritage research staff from our community partners collected data involving 306 NH/PI adults using several community-based recruitment methods (e-mail, telephone, in-person) and two survey approaches: online and paper-and-pencil. Multivariate regressions were conducted to examine potential predictors of NH/PI alcohol use disorder and need for behavioural health treatment.Results
During COVID-19, 47% and 22% of NH/PI adults reported current alcohol and cigarette use, while 35% reported lifetime illicit substance use (e.g., cannabis, opioid). Depression and anxiety were high, and alcohol use disorder, major depression and generalised anxiety disorder prevalence were 27%, 27% and 19%, respectively. One-third of participants reported past-year treatment need with lifetime illicit substance use, COVID-19 distress and major depression respectively associating with 3.0, 1.2, and 5.3 times greater adjusted odds for needing treatment.Conclusions
NH/PI adults reported heavy ATOD use, depression, anxiety and treatment need during COVID-19. Targeted research and treatment services may be warranted to mitigate COVID-19's negative behavioural health impact on NH/PI communities.Item Open Access Randomized trial comparing mindfulness training for smokers to a matched control.(J Subst Abuse Treat, 2014-09) Davis, James M; Manley, Alison R; Goldberg, Simon B; Smith, Stevens S; Jorenby, Douglas ESmoking continues to take an enormous toll on society, and although most smokers would like to quit, most are unsuccessful using existing therapies. These findings call on researchers to develop and test therapies that provide higher rates of long-term smoking abstinence. We report results of a randomized controlled trial comparing a novel smoking cessation treatment using mindfulness training to a matched control based on the American Lung Association's Freedom From Smoking program. Data were collected on 175 low socioeconomic status smokers in 2011-2012 in a medium sized midwestern city. A significant difference was not found in the primary outcome; intent-to-treat biochemically confirmed 6-month smoking abstinence rates were mindfulness=25.0%, control=17.9% (p=0.35). Differences favoring the mindfulness condition were found on measures of urges and changes in mindfulness, perceived stress, and experiential avoidance. While no significant differences were found in quit rates, the mindfulness intervention resulted in positive outcomes.Item Open Access Robinson Crusoe as Promotion Literature: the Reality of English Settlement in the Chesapeake, 1624-1680(2019-06-06) Dowdy, BeverlyIn the seventeenth century a minimum of one hundred thousand English indentured servants emigrated to the Chesapeake Bay of North America. Virginia and Maryland plantations used indentured servitude in the production of one important colonial crop: tobacco. Compared to their countrymen and women at home, the English suffered extremely high mortality rates. To understand possible causes and material conditions, my method involved reviewing both historical literature and material evidence. I interviewed the Director of Education of the Godiah Spray tobacco plantation at the historic colonial capital of St. Mary’s City, Maryland. The Godiah Spray is a working seventeenth century plantation that replicates the work and management of tobacco. I also drew information from archaeological studies of skeletal remains in Chesapeake colonial graves examined by forensic anthropologists of the Smithsonian. This study examines three promotional emigration tracts written by Englishmen in that century. I also examine other monuments of literary promotion that came to embody the myth that anyone could succeed in the New World: Daniel Defoe’s Robinson Crusoe and Moll Flanders. Why was there such a large disconnect between the high mortality rates in the Chesapeake and the supreme confidence of immigrant success authored by Defoe? I will argue that in his novels Defoe was handing his audience a script which demonstrated how to work and become rich in the New World. Robinson Crusoe, along with many other of Defoe’s works, functioned as propaganda to counter the dismal reputation of the colonies and to convince the English to emigrate.Item Open Access Self-administration by female rats of low doses of nicotine alone vs. nicotine in tobacco smoke extract.(Drug and alcohol dependence, 2021-11) Levin, Edward D; Wells, Corinne; Pace, Caroline; Abass, Grant; Hawkey, Andrew; Holloway, Zade; Rezvani, Amir H; Rose, Jed EBackground
Nicotine has reinforcing effects, but there are thousands of other compounds in tobacco, some of which might interact with nicotine reinforcement.Aims
This rat study was conducted to determine if nicotine self-administration is altered by co-administration of the complex mixture of compounds in tobacco smoke extract (TSE).Methods
Female Sprague-Dawley rats were tested for self-administration of low doses of nicotine (3 or 10 µg/kg/infusion) at three different rates of reinforcement (FR1, FR3 and FR5) over three weeks either alone or together with the complex mixture of tobacco smoke extract (TSE).Results
Rats self-administering 3 µg/kg/infusion of nicotine alone showed a rapid initiation on an FR1 schedule, but declined with FR5. Rats self-administering nicotine in TSE acquired self-administration more slowly, but increased responding over the course of the study. With 10 µg/kg/infusion rats self-administered significantly more nicotine alone than rats self-administering the same nicotine dose in TSE. Rats self-administering nicotine alone took significantly more infusions with the 10 than the 3 µg/kg/infusion dose, whereas rats self-administering nicotine in TSE did not. Nicotine in TSE led to a significantly greater locomotor hyperactivity at a dose of 0.1 mg/kg compared to rats that received nicotine alone. Rats self-administering nicotine alone had significantly more responding on the active vs. inactive lever, but rats self-administering the same nicotine doses in TSE did not.Conclusions
Self-administration of nicotine in a purer form appears to be more clearly discriminated and dose-related than nicotine self-administered in the complex mixture of TSE.Item Open Access Spatially Varying Associations of Neighborhood Disadvantage with Alcohol and Tobacco Retail Outlet Rates.(International journal of environmental research and public health, 2022-04-26) Wheeler, David C; Boyle, Joseph; Barsell, D Jeremy; Glasgow, Trevin; McClernon, F Joseph; Oliver, Jason A; Fuemmeler, Bernard FMore than 30% of cancer related deaths are related to tobacco or alcohol use. Controlling and restricting access to these cancer-causing products, especially in communities where there is a high prevalence of other cancer risk factors, has the potential to improve population health and reduce the risk of specific cancers associated with these substances in more vulnerable population subgroups. One policy-driven method of reducing access to these cancer-causing substances is to regulate where these products are sold through the placement and density of businesses selling tobacco and alcohol. Previous work has found significant positive associations between tobacco, alcohol, and tobacco and alcohol retail outlets (TRO, ARO, TARO) and a neighborhood disadvantage index (NDI) using Bayesian shared component index modeling, where NDI associations differed across outlet types and relative risks varied by population density (e.g., rural, suburban, urban). In this paper, we used a novel Bayesian index model with spatially varying effects to explore spatial nonstationarity in NDI effects for TROs, AROs, and TAROs across census tracts in North Carolina. The results revealed substantial variation in NDI effects that varied by outlet type. However, all outlet types had strong positive effects in one coastal area. The most important variables in the NDI were percent renters, Black racial segregation, and the percentage of homes built before 1940. Overall, more disadvantaged areas experienced a greater neighborhood burden of outlets selling one or both of alcohol and tobacco.Item Open Access The Persistence of Smoke: Opera in One Act, Libretto by John Justice(2011) Lam, George Tsz-KwanThe Persistence of Smoke is a documentary opera. The libretto is based on interviews with various individuals related to the former Liggett and Myers Tobacco Company headquarters in Durham, North Carolina.
The cigarette industry once dominated Durham, but saw its decline in the 1990s as the link between cancer and smoking became increasingly clear. The American Tobacco Company and the Liggett and Myers Tobacco Company were once the biggest cigarette manufacturers in the city. As these companies left Durham, their factories and tobacco warehouses first sat vacant, but were gradually preserved and transformed into new spaces for offices, apartments and restaurants.
This project focused on the former Liggett and Myers headquarters along Main Street, a collection of buildings now known as "West Village". I interviewed current and former Durham residents who had a connection with these buildings, including local business representatives, community leaders, former Liggett employees, historians, current residents in the downtown area, municipal urban planners, journalists, and an architect. These interviews were given to local playwright John Justice, who created a libretto based on the themes that emerged.
The opera's story focuses on Kevin, an architect about to unveil his visionary master plan for redeveloping several defunct cigarette factories in an unnamed city. As Kevin leaves his newly renovated apartment for the press conference, he is confronted by his estranged father Curtis, a former cigarette worker who desperately wants to reconcile and reconnect, deliriously recalling the glory days of tobacco and the money that followed.