Browsing by Subject "UNITED-STATES"
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Item Open Access A comprehensive assessment of patient reported symptom burden, medical comorbidities, and functional well being in patients initiating direct acting antiviral therapy for chronic hepatitis C: Results from a large US multi-center observational study.(PloS one, 2018-01) Evon, Donna M; Stewart, Paul W; Amador, Jipcy; Serper, Marina; Lok, Anna S; Sterling, Richard K; Sarkar, Souvik; Golin, Carol E; Reeve, Bryce B; Nelson, David R; Reau, Nancy; Lim, Joseph K; Reddy, K Rajender; Di Bisceglie, Adrian M; Fried, Michael WSymptom burden, medical comorbidities, and functional well-being of patients with chronic hepatitis C virus (HCV) initiating direct acting antiviral (DAA) therapy in real-world clinical settings are not known. We characterized these patient-reported outcomes (PROs) among HCV-infected patients and explored associations with sociodemographic, liver disease, and psychiatric/substance abuse variables.PROP UP is a large US multicenter observational study that enrolled 1,600 patients with chronic HCV in 2016-2017. Data collected prior to initiating DAA therapy assessed the following PROs: number of medical comorbidities; neuropsychiatric, somatic, gastrointestinal symptoms (PROMIS surveys); overall symptom burden (Memorial Symptom Assessment Scale); and functional well-being (HCV-PRO). Candidate predictors included liver disease markers and patient-reported sociodemographic, psychiatric, and alcohol/drug use features. Predictive models were explored using a random selection of 700 participants; models were then validated with data from the remaining 900 participants. The cohort was 55% male, 39% non-white, 48% had cirrhosis (12% with advanced cirrhosis); 52% were disabled or unemployed; 63% were on public health insurance or uninsured; and over 40% had markers of psychiatric illness. The median number of medical comorbidities was 4 (range: 0-15), with sleep disorders, chronic pain, diabetes, joint pain and muscle aches being present in 20-50%. Fatigue, sleep disturbance, pain and neuropsychiatric symptoms were present in over 60% and gastrointestinal symptoms in 40-50%. In multivariable validation models, the strongest and most frequent predictors of worse PROs were disability, unemployment, and use of psychiatric medications, while liver markers generally were not.This large multi-center cohort study provides a comprehensive and contemporary assessment of the symptom burden and comorbid medical conditions in patients with HCV treated in real world settings. Pain, fatigue, and sleep disturbance were common and often severe. Sociodemographic and psychiatric markers were the most robust predictors of PROs. Future research that includes a rapidly changing population of HCV-infected individuals needs to evaluate how DAA therapy affects PROs and elucidate which symptoms resolve with viral eradication.(Clinicaltrial.gov: NCT02601820).Item Open Access Competing for global capital or local voters? The politics of business location incentives(Public Choice, 2015-09) Jensen, NM; Malesky, EJ; Walsh, M© 2015, Springer Science+Business Media New York. The competition for global capital has led to interjurisdictional competition between countries, states and cities as to who can offer the most attractive incentives to firms. In this study, we examine the domestic politics of this competition by focusing on incentive use in the United States from 1999 to 2012. We define incentives as the targeted tax deductions or exemptions that are used to lure businesses into a locality. Drawing on data from municipal incentive programs, we examine how electoral competition shapes the use and oversight of targeted incentives. We find evidence that cities with elected mayors provide larger incentives than non-elected city managers by taking advantage of exogeneity in the assignment of city government institutions and a database of over 2000 investment incentives from 2010 to 2012. We also find that elected mayors enjoy more lax oversight of incentive projects than their appointed counterparts. Our results have important implications for the study of interjurisdictional competition and the role of electoral institutions in shaping economic policy.Item Open Access E-cigarette prevalence and correlates of use among adolescents versus adults: A review and comparison(Journal of Psychiatric Research, 2014) Carroll Chapman, SL; Wu, L-TPerceived safer than tobacco cigarettes, prevalence of electronic cigarette (e-cigarette) use is increasing. Analyses of cartridges suggest that e-cigarettes may pose health risks. In light of increased use and the potential for consequences, we searched Google Scholar and Pubmed in July of 2013 using keywords, such as e-cigarette and vaping, to compare differences and similarities in prevalence and correlates of e-cigarette use among adolescents (grades 6-12) versus adults (aged ≥18 years). Twenty-one studies focused on e-cigarette use. Ever-use increased among various age groups. In 2011, ever-use was highest among young adults (college students and those aged 20-28; 4.9%-7.0%), followed by adults (aged ≥18; 0.6%-6.2%), and adolescents (grades 6-12 and aged 11-19; <1%-3.3%). However, in 2012 adolescent ever-use increased to 6.8% and, among high school students, went as high as 10.0%. While the identified common correlate of e-cigarette use was a history of cigarette smoking, a notable proportion of adolescents and young adults who never smoked cigarettes had ever-used e-cigarettes. E-cigarette use was not consistently associated with attempting to quit tobacco among young adults. Adults most often reported e-cigarettes as a substitute for tobacco, although not always to quit. Reviewed studies showed a somewhat different pattern of e-cigarette use among young people (new e-cigarette users who had never used tobacco) versus adults (former or current tobacco users). Research is needed to better characterize prevalences, use correlates, and motives of use in different population groups, including how adolescent and young adult experimentation with e-cigarettes relates to other types of substance use behaviors. © 2014 Elsevier Ltd. All rights reserved.Item Open Access Evaluating the best available social science for natural resource management decision-making(Environmental Science and Policy, 2017-07-01) Charnley, S; Carothers, C; Satterfield, T; Levine, A; Poe, MR; Norman, K; Donatuto, J; Breslow, SJ; Mascia, MB; Levin, PS; Basurto, X; Hicks, CC; García-Quijano, C; St. Martin, K© 2017 Increasing recognition of the human dimensions of natural resource management issues, and of social and ecological sustainability and resilience as being inter-related, highlights the importance of applying social science to natural resource management decision-making. Moreover, a number of laws and regulations require natural resource management agencies to consider the “best available science” (BAS) when making decisions, including social science. Yet rarely do these laws and regulations define or identify standards for BAS, and those who have tried to fill the gap have done so from the standpoint of best available natural science. This paper proposes evaluative criteria for best available social science (BASS), explaining why a broader set of criteria than those used for natural science is needed. Although the natural and social sciences share many of the same evaluative criteria for BAS, they also exhibit some differences, especially where qualitative social science is concerned. Thus we argue that the evaluative criteria for BAS should expand to include those associated with diverse social science disciplines, particularly the qualitative social sciences. We provide one example from the USA of how a federal agency − the U.S. Forest Service − has attempted to incorporate BASS in responding to its BAS mandate associated with the national forest planning process, drawing on different types of scientific information and in light of these criteria. Greater attention to including BASS in natural resource management decision-making can contribute to better, more equitable, and more defensible management decisions and policies.Item Open Access Genes, Race, and Causation: US Public Perspectives About Racial Difference(Race and Social Problems, 2018-06-01) Outram, Simon; Graves, Joseph L; Powell, Jill; Wolpert, Chantelle; Haynie, Kerry L; Foster, Morris W; Blanchard, Jessica W; Hoffmeyer, Anna; Agans, Robert P; Royal, Charmaine Dm© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Concerns have been raised that the increase in popular interest in genetics may herald a new era within which racial inequities are seen as “natural” or immutable. In the following study, we provide data from a nationally representative survey on how the US population perceives general ability, athleticism, and intellect being determined by race and/or genetics and whether they believe racial health inequities to be primarily the product of genetic or social factors. We find that self-described race is of primary importance in attributing general ability to race, increasing age is a significant factor in attributing athleticism and intellect to genes and race, and education is a significant factor in decreasing such racially and genetically deterministic views. Beliefs about the meaning of race are statistically significantly associated with respect to the perception of athletic abilities and marginally associated with the perception of racial health inequalities being either socially or genetically derived. Race, education, socioeconomic status, and concepts of race were frequently found to be multiplicative in their statistical effects. The persistent acceptance of a genetically and racially deterministic view of athleticism among the White and older population group is discussed with respect to its social impact, as is the high level of agreement that general abilities are determined by race among non-White respondents and those of lower socioeconomic status. We argue that these findings highlight that both biological and non-biological forms of understanding race continue to play a role into the politics of race and social difference within contemporary US society.Item Open Access Germline Genetic Testing: What the Breast Surgeon Needs to Know.(Annals of surgical oncology, 2019-07) Plichta, Jennifer K; Sebastian, Molly L; Smith, Linda A; Menendez, Carolyn S; Johnson, Anita T; Bays, Sussan M; Euhus, David M; Clifford, Edward J; Jalali, Mena; Kurtzman, Scott H; Taylor, Walton A; Hughes, Kevin SPURPOSE:The American Society of Breast Surgeons (ASBrS) sought to provide educational guidelines for breast surgeons on how to incorporate genetic information and genomics into their practice. METHODS:A comprehensive nonsystematic review was performed of selected peer-reviewed literature. The Genetics Working Group of the ASBrS convened to develop guideline recommendations. RESULTS:Clinical and educational guidelines were prepared to outline the essential knowledge for breast surgeons to perform germline genetic testing and to incorporate the findings into their practice, which have been approved by the ASBrS Board of Directors. RECOMMENDATIONS:Thousands of women in the USA would potentially benefit from genetic testing for BRCA1, BRCA2, and other breast cancer genes that markedly increase their risk of developing breast cancer. As genetic testing is now becoming more widely available, women should be made aware of these tests and consider testing. Breast surgeons are well positioned to help facilitate this process. The areas where surgeons need to be knowledgeable include: (1) identification of patients for initial breast cancer-related genetic testing, (2) identification of patients who tested negative in the past but now need updated testing, (3) initial cancer genetic testing, (4) retesting of patients who need their genetic testing updated, (5) cancer genetic test interpretation, posttest counseling and management, (6) management of variants of uncertain significance, (7) cascade genetic testing, (8) interpretation of genetic tests other than clinical cancer panels and the counseling and management required, and (9) interpretation of somatic genetic tests and the counseling and management required.Item Open Access Household Charitable Giving at the Intersection of Gender, Marital Status, and Religion(Nonprofit and Voluntary Sector Quarterly, 2018-02) Eagle, D; Keister, LA; Read, JG© 2017, © The Author(s) 2017. Past research reveals mixed results regarding the relationship between gender and charitable giving. We show gender plays a significant role in giving but only when considered alongside marital status and religion. Using the 2006 Portraits of American Life Study, we model a household’s propensity to give and the amount given. We extend past research by disaggregating unmarried households to look at divorced, widowed, and never-married households, and by including multiple religion measures. Results indicate households headed by never-married females have lower giving levels compared with those headed by divorced and widowed women. In households headed by single males, these differences are largely absent. Religious attendance has a stronger association with giving in male-headed households. The respondent’s gender is also related to the amount married households report giving to charity. Future research on giving should consider both gender and marital status to more fully capture increasing diversity in American families.Item Open Access Soil production and the soil geomorphology legacy of Grove Karl Gilbert(Soil Science Society of America Journal, 2020-01-01) Richter, DD; Eppes, MC; Austin, JC; Bacon, AR; Billings, SA; Brecheisen, Z; Ferguson, TA; Markewitz, D; Pachon, J; Schroeder, PA; Wade, AM© 2019 The Authors. Soil Science Society of America published by Wiley Periodicals, Inc. on behalf of Soil Science Society of America Geomorphologists are quantifying the rates of an important component of bedrock's weathering in research that needs wide discussion among soil scientists. By using cosmogenic nuclides, geomorphologists estimate landscapes’ physical lowering, which, in a steady landscape, equates to upward transfers of weathered rock into slowly moving hillslope-soil creep. Since the 1990s, these processes have been called “soil production” or “mobile regolith production”. In this paper, we assert the importance of a fully integrated pedological and geomorphological approach not only to soil creep but to soil, regolith, and landscape evolution; we clarify terms to facilitate soil geomorphology collaboration; and we seek a greater understanding of our sciences’ history. We show how the legacy of Grove Karl Gilbert extend across soil geomorphology. We interpret three contrasting soils and regoliths in the USA's Southern Piedmont in the context of a Gilbert-inspired model of weathering and transport, a model of regolith evolution and of nonsteady systems that liberate particles and solutes from bedrock and transport them across the landscape. This exercise leads us to conclude that the Southern Piedmont is a region with soils and regoliths derived directly from weathering bedrock below (a regional paradigm for more than a century) but that the Piedmont also has significant areas in which regoliths are at least partly formed from paleo-colluvia that may be massive in volume and overlie organic-enriched layers, peat, and paleo-saprolite. An explicitly integrated study of soil geomorphology can accelerate our understanding of soil, regoliths, and landscape evolution in all physiographic regions.Item Open Access TGFβ1 Genetic Variants Predict Clinical Outcomes of HPV-Positive Oropharyngeal Cancer Patients after Definitive Radiotherapy.(Clinical cancer research : an official journal of the American Association for Cancer Research, 2018-05) Tao, Ye; Sturgis, Erich M; Huang, Zhigang; Wang, Ying; Wei, Peng; Wang, Jennifer Rui; Wei, Qingyi; Li, GuojunPurpose: TGFβ1 plays a critical role in inflammation and immune responses and treatment response and survival. TGFβ1 variants may affect its expression level or functional efficiency, thus modifying tumor status and survival in human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx (SCCOP).Experimental Design: We determined tumor HPV16 status and genotyped three TGFβ1 polymorphisms in 564 incident SCCOP patients treated with radiotherapy or chemoradiation. Univariate and multivariable Cox models were used to evaluate the associations between the three polymorphisms and survival.Results: Overall, 85% of patients (482 of 564) had HPV16-positive SCCOP. We found that TGFβ1 rs1982073 had statistically significant associations with survival, whereas TGFβ1 rs1800469 and TGFβ1 rs1800471 did not. Patients with TGFβ1 rs1982073 CT/CC variant genotypes had significantly better overall, disease-specific, and disease-free survival compared with those with the corresponding common homozygous TT genotype (all log-rank: P < 0.001). Furthermore, these genotypes were significantly associated with an approximately 5 times reduced risk of overall death, death owing to disease, and recurrence after multivariable adjustment. Moreover, the stratified analyses by tumor HPV status indicated that the significant effects of TGFβ1 rs1982073 polymorphism on survival were found among HPV16-positive SCCOP patients only. Finally, the functional relevance of these variants was further characterized.Conclusions: Our findings support that the TGFβ1 rs1982073 polymorphism plays a significant role in the prognosis of SCCOP, especially in HPV16-positive SCCOP patients treated with chemoradiation. Prospective studies with larger sample sizes are needed to confirm these findings. Clin Cancer Res; 24(9); 2225-33. ©2018 AACR.Item Open Access The Emergence of Organizational Forms: A Community Ecology Approach(American Journal of Sociology, 2000) Ruef, MThis article introduces a new ecological approach to the study of form emergence based on the notion of an organizational community - a bounded set of forms with related identities. Applying the approach to 48 organizational forms in the health care sector, this study suggests that the development of novel forms is affected by the positioning of their identities with respect to existing form identities in the community, by the aggregate density and size of organizations matching those existing identities, and by the amount of attention directed at identity attributes by sector participants. Findings show that the process of form emergence is subject to population-dependent effects akin to those noted previously for organizational entries within established populations. The aggregate density and size of organizations with similar identities increase the probability of form emergence to a point (cross-form legitimation), but highly saturated regions of the identity space tend to be uninviting to new forms (cross-form competition).Item Open Access The Historical Demography of Racial Segregation(American Sociological Review, 2015) Grigoryeva, A; Ruef, MStandard measures of residential segregation tend to equate spatial with social proximity. This assumption has been increasingly subject to critique among demographers and ethnographers and becomes especially problematic in historical settings. In the late nineteenth-century United States, standard measures suggest a counterintuitive pattern: southern cities, with their long history of racial inequality, had less residential segregation than urban areas considered to be more racially tolerant. By using census enumeration procedures, we develop a sequence measure that captures a more subtle “backyard” pattern of segregation, where white families dominated front streets and blacks were relegated to alleys. Our analysis of complete household data from the 1880 Census documents how segregation took various forms across the postbellum United States. Whereas northern cities developed segregation via racialized neighborhoods, substituting residential inequality for the status inequality of slavery, southern cities embraced street-front segregation that reproduced the racial inequality that existed under slavery.Item Open Access What is Organizational History? Towards a Creative Synthesis of History and Organization Studies(Academy of Management Review, 2016) Godfrey, P; Hassard, J; O'Connor, E; Rowlinson, M; Ruef, MAs a synthesis of organization theory and historiography, the field of organizational history is mature enough to contribute to wider theoretical and historiographical debates and is sufficiently developed for a theoretical consideration of its subject matter. In this introduction to the Special Topic Forum on History and Organization Studies, we take up the question, "What is organizational history?" and consider three distinct arguments that we believe frame the next phase of development for historical work within organization studies. First, we argue that following the "historic turn," organizational history has developed as a subfield of organization studies that takes seriously the matter of history, promoting historical research as a way to enrich the broad endeavor of organization. Second, if "historymatters," then organization theory needs a theoretical account of the past that goes beyond the mere use of history as a context to test or as an example to illustrate theory. Third, the focus on "history that matters" in the present leads to two important considerations: How organizations can use "rhetorical history" as a strategic resource and the need to engage with historiographically significant subjects that connect organization theory to larger humanistic concerns, such as slavery and racism.