Browsing by Subject "VD, vessel density"

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    Intrasession Repeatability of OCT Angiography Parameters in Neurodegenerative Disease.
    (Ophthalmology science, 2023-06) Akrobetu, Dennis Y; Robbins, Cason B; Ma, Justin P; Soundararajan, Srinath; Quist, Michael S; Stinnett, Sandra S; Moore, Kathryn PL; Johnson, Kim G; Liu, Andy J; Grewal, Dilraj S; Fekrat, Sharon

    Purpose

    To assess the intrasession repeatability of macular OCT angiography (OCTA) parameters in Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), and normal cognition (NC).

    Design

    Cross sectional study.

    Subjects

    Patients with a clinical diagnosis of AD, PD, MCI, or NC were imaged. Images with poor quality and of those with diabetes mellitus, glaucoma, or vitreoretinal disease were excluded from analysis.

    Methods intervention or testing

    All participants were imaged using the Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Software Version 11.0.0.29946) and repeat OCTA images were obtained for both eyes. Perfusion density (PFD), vessel density (VD), and Foveal avascular zone (FAZ) area were measured from 3 × 3 mm and 6 × 6 mm OCTA images centered on the fovea using an ETDRS grid overlay.

    Main outcome measures

    Intraclass correlation coefficients were used to quantify repeatability of PFD, VD, and FAZ area measurements obtained from imaging.

    Results

    3 × 3 mm scans of 22 AD, 40 MCI, 21 PD, and 26 NC participants and 6 × 6 mm scans of 29 AD, 44 MCI, 29 PD, and 30 NC participants were analyzed. Repeatability values ranged from 0.64 (0.49-0.82) for 6 × 6 mm PFD in AD participants to 0.87 (0.67-0.92) for 3 × 3 mm PFD in AD participants. No significant differences were observed in repeatability between NC participants and those with neurodegenerative disease.

    Conclusions

    Overall, similar OCTA repeatability was observed between NC participants and those with neurodegeneration. Regardless of diagnostic group, macular OCTA metrics demonstrated moderate to good repeatability.

    Financial disclosures

    The authors have no proprietary or commercial interest in any materials discussed in this article.
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    Retinal and Choroidal Changes in Men Compared with Women with Alzheimer's Disease: A Case-Control Study.
    (Ophthalmology science, 2022-03) Mirzania, Delaram; Thompson, Atalie C; Robbins, Cason B; Soundararajan, Srinath; Lee, Jia Min; Agrawal, Rupesh; Liu, Andy J; Johnson, Kim G; Grewal, Dilraj S; Fekrat, Sharon

    Purpose

    To evaluate differences in the retinal microvasculature and structure and choroidal structure among men and women with Alzheimer's disease (AD) compared with age-matched cognitively normal male and female controls.

    Design

    Case-control study of participants ≥ 50 years of age.

    Participants

    A total of 202 eyes of 139 subjects (101 cases and 101 controls).

    Methods

    All participants and controls underwent OCT and OCT angiography (OCTA), and parameters of subjects with AD were compared with those of cognitively normal controls.

    Main outcome measures

    The foveal avascular zone (FAZ) area, vessel density (VD), and perfusion density (PD) in the superficial capillary plexus within the 3- and 6-mm circle and ring using Early Treatment Diabetic Retinopathy Study (ETDRS) grid overlay on OCTA; central subfield thickness (CST), retinal nerve fiber layer (RNFL) thickness, ganglion cell-inner plexiform layer (GCIPL) thickness, and choroidal vascularity index (CVI) on OCT.

    Results

    No significant sex differences in VD or PD were found in the AD or control cohorts; however, there were greater differences in VD and PD among AD female participants than AD male participants compared with their respective controls. The CST and FAZ area were not different between male and female AD participants. Among controls, men had a thicker CST (P < 0.001) and smaller FAZ area (P = 0.003) compared with women. The RNFL thickness, GCIPL thickness, and CVI were similar among male and female AD participants and controls.

    Conclusions

    There may be a loss of the physiologic sex-related differences in retinal structure and microvasculature in those with AD compared with controls. Further studies are needed to elucidate the pathophysiological basis for these findings.