Browsing by Subject "censored-by-death"

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    An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.
    (Stat Methods Med Res, 2016-01-01) Matsouaka, Roland A; Singhal, Aneesh B; Betensky, Rebecca A
    We consider a two-group randomized clinical trial, where mortality affects the assessment of a follow-up continuous outcome. Using the worst-rank composite endpoint, we develop a weighted Wilcoxon-Mann-Whitney test statistic to analyze the data. We determine the optimal weights for the Wilcoxon-Mann-Whitney test statistic that maximize its power. We derive a formula for its power and demonstrate its accuracy in simulations. Finally, we apply the method to data from an acute ischemic stroke clinical trial of normobaric oxygen therapy.