Browsing by Subject "cross validation"
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Item Open Access Facebook Account Misuse Detection -- A Statistical Approach(2013-06-30) Chai, CPPrivacy of personal information on social networking websites has become an important issue, because when a social networking website account is used by a person other than the owner, all personal data stored on the website can be retrieved, no matter how the owner sets the privacy options. Therefore, this paper proposes a statistical approach with the use of Support Vector Machine (SVM) to detect whether the Facebook account user is the actual owner. By analyzing online browsing behavior features, it is found that the normal user tends to be more active and that the stealthy user prefers to read personal messages.Item Open Access Predicting the Risk of Huntington's Disease with Multiple Longitudinal Biomarkers.(Journal of Huntington's disease, 2019-06-22) Li, Fan; Li, Kan; Li, Cai; Luo, Sheng; PREDICT-HD and ENROLL-HD Investigators of the Huntington Study GroupBACKGROUND:Huntington's disease (HD) has gradually become a public health threat, and there is a growing interest in developing prognostic models to predict the time for HD diagnosis. OBJECTIVE:This study aims to develop a novel prognostic model that leverages multiple longitudinal biomarkers to inform the risk of HD. METHODS:The multivariate functional principal component analysis was used to summarize the essential information from multiple longitudinal markers and to obtain a set of prognostic scores. The prognostic scores were used as predictors in a Cox model to predict the right-censored time to diagnosis. We used cross-validation to determine the best model in PREDICT-HD (n = 1,039) and ENROLL-HD (n = 1,776); external validation was carried out in ENROLL-HD. RESULTS:We considered six commonly measured longitudinal biomarkers in PREDICT-HD and ENROLL-HD (Total Motor Score, Symbol Digit Modalities Test, Stroop Word Test, Stroop Color Test, Stroop Interference Test, and Total Functional Capacity). The prognostic model utilizing these longitudinal biomarkers significantly improved the predictive performance over the model with baseline biomarker information. A new prognostic index was computed using the proposed model, and can be dynamically updated over time as new biomarker measurements become available. CONCLUSION:Longitudinal measurements of commonly measured clinical biomarkers substantially improve the risk prediction of Huntington's disease diagnosis. Calculation of the prognostic index informs the patient's risk category and facilitates patient selection in future clinical trials.