Browsing by Subject "deep brain stimulation"

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    Deep brain stimulation for tremor associated with underlying ataxia syndromes: a case series and discussion of issues.
    (Tremor Other Hyperkinet Mov (N Y), 2014) Oyama, Genko; Thompson, Amanda; Foote, Kelly D; Limotai, Natlada; Abd-El-Barr, Muhammad; Maling, Nicholas; Malaty, Irene A; Rodriguez, Ramon L; Subramony, Sankarasubramoney H; Ashizawa, Tetsuo; Okun, Michael S
    BACKGROUND: Deep brain stimulation (DBS) has been utilized to treat various symptoms in patients suffering from movement disorders such as Parkinson's disease, dystonia, and essential tremor. Though ataxia syndromes have not been formally or frequently addressed with DBS, there are patients with ataxia and associated medication refractory tremor or dystonia who may potentially benefit from therapy. METHODS: A retrospective database review was performed, searching for cases of ataxia where tremor and/or dystonia were addressed by utilizing DBS at the University of Florida Center for Movement Disorders and Neurorestoration between 2008 and 2011. Five patients were found who had DBS implantation to address either medication refractory tremor or dystonia. The patient's underlying diagnoses included spinocerebellar ataxia type 2 (SCA2), fragile X associated tremor ataxia syndrome (FXTAS), a case of idiopathic ataxia (ataxia not otherwise specified [NOS]), spinocerebellar ataxia type 17 (SCA17), and a senataxin mutation (SETX). RESULTS: DBS improved medication refractory tremor in the SCA2 and the ataxia NOS patients. The outcome for the FXTAS patient was poor. DBS improved dystonia in the SCA17 and SETX patients, although dystonia did not improve in the lower extremities of the SCA17 patient. All patients reported a transient gait dysfunction postoperatively, and there were no reports of improvement in ataxia-related symptoms. DISCUSSION: DBS may be an option to treat tremor, inclusive of dystonic tremor in patients with underlying ataxia; however, gait and other symptoms may possibly be worsened.
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    Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology.
    (Frontiers in human neuroscience, 2020-01) Ramirez-Zamora, Adolfo; Giordano, James; Gunduz, Aysegul; Alcantara, Jose; Cagle, Jackson N; Cernera, Stephanie; Difuntorum, Parker; Eisinger, Robert S; Gomez, Julieth; Long, Sarah; Parks, Brandon; Wong, Joshua K; Chiu, Shannon; Patel, Bhavana; Grill, Warren M; Walker, Harrison C; Little, Simon J; Gilron, Ro'ee; Tinkhauser, Gerd; Thevathasan, Wesley; Sinclair, Nicholas C; Lozano, Andres M; Foltynie, Thomas; Fasano, Alfonso; Sheth, Sameer A; Scangos, Katherine; Sanger, Terence D; Miller, Jonathan; Brumback, Audrey C; Rajasethupathy, Priya; McIntyre, Cameron; Schlachter, Leslie; Suthana, Nanthia; Kubu, Cynthia; Sankary, Lauren R; Herrera-Ferrá, Karen; Goetz, Steven; Cheeran, Binith; Steinke, G Karl; Hess, Christopher; Almeida, Leonardo; Deeb, Wissam; Foote, Kelly D; Okun, Michael S
    The Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of 2019 addressed the most current: (1) use and utility of complex neurophysiological signals for development of adaptive neurostimulation to improve clinical outcomes; (2) Advancements in recent neuromodulation techniques to treat neuropsychiatric disorders; (3) New developments in optogenetics and DBS; (4) The use of augmented Virtual reality (VR) and neuromodulation; (5) commercially available technologies; and (6) ethical issues arising in and from research and use of DBS. These advances serve as both "markers of progress" and challenges and opportunities for ongoing address, engagement, and deliberation as we move to improve the functional capabilities and translational value of DBS. It is in this light that these proceedings are presented to inform the field and initiate ongoing discourse. As consistent with the intent, and spirit of this, and prior DBS Think Tanks, the overarching goal is to continue to develop multidisciplinary collaborations to rapidly advance the field and ultimately improve patient outcomes.