Browsing by Subject "diffusion"

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    Cross-hemispheric collaboration and segregation associated with task difficulty as revealed by structural and functional connectivity.
    (J Neurosci, 2015-05-27) Davis, Simon W; Cabeza, Roberto
    Although it is known that brain regions in one hemisphere may interact very closely with their corresponding contralateral regions (collaboration) or operate relatively independent of them (segregation), the specific brain regions (where) and conditions (how) associated with collaboration or segregation are largely unknown. We investigated these issues using a split field-matching task in which participants matched the meaning of words or the visual features of faces presented to the same (unilateral) or to different (bilateral) visual fields. Matching difficulty was manipulated by varying the semantic similarity of words or the visual similarity of faces. We assessed the white matter using the fractional anisotropy (FA) measure provided by diffusion tensor imaging (DTI) and cross-hemispheric communication in terms of fMRI-based connectivity between homotopic pairs of cortical regions. For both perceptual and semantic matching, bilateral trials became faster than unilateral trials as difficulty increased (bilateral processing advantage, BPA). The study yielded three novel findings. First, whereas FA in anterior corpus callosum (genu) correlated with word-matching BPA, FA in posterior corpus callosum (splenium-occipital) correlated with face-matching BPA. Second, as matching difficulty intensified, cross-hemispheric functional connectivity (CFC) increased in domain-general frontopolar cortex (for both word and face matching) but decreased in domain-specific ventral temporal lobe regions (temporal pole for word matching and fusiform gyrus for face matching). Last, a mediation analysis linking DTI and fMRI data showed that CFC mediated the effect of callosal FA on BPA. These findings clarify the mechanisms by which the hemispheres interact to perform complex cognitive tasks.
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    From divots to swales: Hillslope sediment transport across divers length scales
    (2010) Furbish, David Jon; Haff, Peter K
    In soil-mantled steeplands, soil motions associated with creep, ravel, rain splash, soil slips, tree throw, and rodent activity are patchy and intermittent and involve widely varying travel distances. To describe the collective effect of these motions, we formulate a nonlocal expression for the soil flux. This probabilistic formulation involves upslope and downslope convolutions of land surface geometry to characterize motions in both directions, notably accommodating the bidirectional dispersal of material on gentle slopes as well as mostly downslope dispersal on steeper slopes, and it distinguishes between the mobilization of soil material and the effect of surface slope in giving a downslope bias to the dispersal of mobilized material. The formulation separates dispersal associated with intermittent surface motions from the slower bulk behavior associated with small-scale bioturbation and similar dilational processes operating mostly within the soil column. With a uniform rate of mobilization of soil material, the nearly parabolic form of a hillslope profile at steady state resembles a diffusive behavior. With a slope-dependent rate of mobilization, the steady state hillslope profile takes on a nonparabolic form where land surface elevation varies with downslope distance x as x(a) with a similar to 3/2, consistent with field observations and where the flux increases nonlinearly with increasing slope. The convolution description of the soil flux, when substituted into a suitable expression of conservation, yields a nonlinear Fokker-Planck equation and can be mapped to discrete particle models of hillslope behavior and descriptions of soil-grain transport by rain splash as a stochastic advection-dispersion process.
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    How Diffusion Impacts Cortical Protein Distribution in Yeasts.
    (Cells, 2020-04-30) Moran, Kyle D; Lew, Daniel J
    Proteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achieve asymmetric distributions of membrane proteins despite the anticipated dissipative effects of diffusion, and highlight recent findings suggesting that differential diffusion is exploited to create, rather than dissipate, asymmetry. We also highlight open questions about diffusion in yeast plasma membranes that remain unsolved.