Browsing by Subject "functional magnetic resonance imaging"

Neuronal current MRI (ncMRI) is a field of study to directly map electrical activity in the brain using MRI, which has many benefits over functional MRI. One potential ncMRI method, Lorentz effect imaging (LEI), has shown promise but needs a better theoretical understanding to improve its use.

We develop three computational models to simulate the LEI experiments of an electrolyte filled phantom subject to a current dipole based on: ion flow, particle drift, and electromagnetohydrodynamics (EMHD). With comparative experimental results, we use the EMHD model to better understand the Lorentz effect over a range of current strengths. We also quantify the LEI experimental images and assess ways to measure the underlying current strength, which would greatly benefit comparative brain mapping.

EMHD is a good predictor of LEI signal loss. We can measure the underlying current strength and polarity in the phantom using LEI images. We can also use trends from the EMHD model results to predict the required current density for signal detection in future LEI experiments. We can also infer the electric field strength, flow velocity, displacement, and pressure from the predicted current magnitude in an LEI experiment.

The EMHD model provides information that greatly improves the utility and understanding of LEI. Future study with our EMHD model should be performed using shorter dipole lengths, higher density and lower strength of current sources, and varying current source frequencies to understand LEI in the setting of mapping brain activity.

Emotion is known to influence multiple aspects of memory formation, which may include the initial encoding of the memory trace, its consolidation over time, and the efficacy of its retrieval. However, prior investigations have tended to treat emotional modulation of episodic memory as a unitary construct, thus conflating the contributions of these different stages to emotion-mediated memory enhancements. The present thesis aims to disentangle the component processes of emotional memory formation and retrieval through a series of studies using cognitive behavioral and functional magnetic resonance imaging (fMRI) methods. In the first 2 studies, neural activity was evaluated during the initial viewing of emotionally arousing and neutral scenes and, in the 3rd study, neural activity during this initial viewing period was compared to that during a recognition memory task. The findings are compatible with the proposal that two distinct networks support successful emotional memory formation: an amygdala-medial temporal lobe (MTL) network that modulates the consolidation of memories over time and a prefrontal-MTL network that translates emotion effects on controlled elaboration into superior memory encoding. The superlative quality of emotional memories is furthermore marked by heightened similarity between neural states at encoding and retrieval, suggesting another line of evidence through which emotion effects can be observed. Taken together, the results presented here highlight the heterogeneity of processes that confer mnemonic advantages to emotionally significant information.