Browsing by Subject "longitudinal"

Now showing 1 - 6 of 6

Open Access
Childhood bullying involvement predicts low-grade systemic inflammation into adulthood.
(Proc Natl Acad Sci U S A, 2014-05-27) Copeland, WE; Wolke, D; Lereya, ST; Shanahan, L; Worthman, C; Costello, EJ
Bullying is a common childhood experience that involves repeated mistreatment to improve or maintain one's status. Victims display long-term social, psychological, and health consequences, whereas bullies display minimal ill effects. The aim of this study is to test how this adverse social experience is biologically embedded to affect short- or long-term levels of C-reactive protein (CRP), a marker of low-grade systemic inflammation. The prospective population-based Great Smoky Mountains Study (n = 1,420), with up to nine waves of data per subject, was used, covering childhood/adolescence (ages 9-16) and young adulthood (ages 19 and 21). Structured interviews were used to assess bullying involvement and relevant covariates at all childhood/adolescent observations. Blood spots were collected at each observation and assayed for CRP levels. During childhood and adolescence, the number of waves at which the child was bullied predicted increasing levels of CRP. Although CRP levels rose for all participants from childhood into adulthood, being bullied predicted greater increases in CRP levels, whereas bullying others predicted lower increases in CRP compared with those uninvolved in bullying. This pattern was robust, controlling for body mass index, substance use, physical and mental health status, and exposures to other childhood psychosocial adversities. A child's role in bullying may serve as either a risk or a protective factor for adult low-grade inflammation, independent of other factors. Inflammation is a physiological response that mediates the effects of both social adversity and dominance on decreases in health.
Open Access
Evaluating risk for adolescent anxiety: The role of preschool sensory over-responsivity and differential volume of subcortical regions
(2023-04-20) Haughey, Connor
Anxiety disorders represent one of the most prevalent groups of mental health disorders and can cause immense problems in psychosocial functioning and overall well-being. Sensory over-responsivity, which is typically only evaluated as a symptom of autism spectrum disorder, represents when an individual experiences an abnormally heightened reaction to at least one sensory stimulus. Recent studies have found that sensory over-responsivity at preschool age is associated with many forms of psychopathology at school age, including anxiety disorders. At present, no studies have examined if this relationship continues later in life nor how sensory over-responsivity manifests structurally in the brain. The primary aim of the present study was to evaluate whether preschool sensory over-responsivity is associated with adolescent anxiety, and whether the volumes of the amygdala, hippocampus, and caudate nucleus at school age might moderate this relationship. We conducted a longitudinal follow-up study that has a sample of 210 adolescents ages 15 to 22 who underwent psychiatric assessment at the preschool age, which included a diagnostic screening for anxiety disorders and sensory over-responsivity. A subset of these 210 adolescents also underwent magnetic resonance brain imaging at school age. At the most recent follow-up, they completed an assessment of anxiety, allowing us to investigate mental health changes across their lifespan. First, we found no significant relationship between preschool sensory over-responsivity and adolescent anxiety. Second, we did not find any significant moderation effect of bilateral amygdala, hippocampus, and caudate nucleus volumes on the relationship between preschool sensory over-responsivity and adolescent anxiety. However, we found a significant interaction between left hippocampus volume at school-age and preschool sensory over-responsivity on total externalizing and internalizing problems. These findings add to the growing literature seeking to understand early life risk factors for anxiety during adolescence. Furthermore, these findings emphasize the role of brain structure, particularly the hippocampus, during early life development in a model of risk for adolescent anxiety.
Open Access
Is chronic asthma associated with shorter leukocyte telomere length at midlife?
(Am J Respir Crit Care Med, 2014-08-15) Belsky, Daniel W; Shalev, Idan; Sears, Malcolm R; Hancox, Robert J; Lee Harrington, Hona; Houts, Renate; Moffitt, Terrie E; Sugden, Karen; Williams, Benjamin; Poulton, Richie; Caspi, Avshalom
RATIONALE: Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging. OBJECTIVES: To test whether chronic asthma is associated with a proposed biomarker of accelerated aging, leukocyte telomere length. METHODS: Asthma was ascertained prospectively in the Dunedin Multidisciplinary Health and Development Study cohort (n = 1,037) at nine in-person assessments spanning ages 9-38 years. Leukocyte telomere length was measured at ages 26 and 38 years. Asthma was classified as life-course-persistent, childhood-onset not meeting criteria for persistence, and adolescent/adult-onset. We tested associations between asthma and leukocyte telomere length using regression models. We tested for confounding of asthma-leukocyte telomere length associations using covariate adjustment. We tested serum C-reactive protein and white blood cell counts as potential mediators of asthma-leukocyte telomere length associations. MEASUREMENTS AND MAIN RESULTS: Study members with life-course-persistent asthma had shorter leukocyte telomere length as compared with sex- and age-matched peers with no reported asthma. In contrast, leukocyte telomere length in study members with childhood-onset and adolescent/adult-onset asthma was not different from leukocyte telomere length in peers with no reported asthma. Adjustment for life histories of obesity and smoking did not change results. Study members with life-course-persistent asthma had elevated blood eosinophil counts. Blood eosinophil count mediated 29% of the life-course-persistent asthma-leukocyte telomere length association. CONCLUSIONS: Life-course-persistent asthma is related to a proposed biomarker of accelerated aging, possibly via systemic eosinophilic inflammation. Life histories of asthma can inform studies of aging.
Open Access
Retaining Adolescent and Young Adult Participants in Research During a Pandemic: Best Practices From Two Large-Scale Developmental Neuroimaging Studies (NCANDA and ABCD).
(Frontiers in behavioral neuroscience, 2020-01) Nooner, Kate B; Chung, Tammy; Feldstein Ewing, Sarah W; Brumback, Ty; Arwood, Zjanya; Tapert, Susan F; Brown, Sandra A; Cottler, Linda
The novel coronavirus pandemic that emerged in late 2019 (COVID-19) has created challenges not previously experienced in human research. This paper discusses two large-scale NIH-funded multi-site longitudinal studies of adolescents and young adults - the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) and the Adolescent Brain Cognitive Development (ABCD) Study - and valuable approaches to learn about adaptive processes for conducting developmentally sensitive research with neuroimaging and neurocognitive testing across consortia during a global pandemic. We focus on challenges experienced during the pandemic and modifications that may guide other projects, such as implementing adapted protocols that protect the safety of participants and research staff, and addressing assessment challenges through the use of strategies such as remote and mobile assessments. Given the pandemic's disproportionate impacts on participants typically underrepresented in research, we describe efforts to retain these individuals. The pandemic provides an opportunity to develop adaptive processes that can facilitate future studies' ability to mobilize effectively and rapidly.
Open Access
Subtypes of childhood social withdrawal and adult relationship and parenting outcomes
(International Journal of Behavioral Development, 2024-01-01) Reilly, EB; Dodge, KA; Bai, Y; Lansford, JE; Bates, JE; Pettit, GS
The aims of the current 30 year prospective study were to determine: (1) whether socially withdrawn kindergarten children are less likely than others to enter serious romantic relationships or become parents by age 34, (2) whether socially withdrawn children parent differently than non-withdrawn individuals when they grow up, and (3) whether subtypes of withdrawal are associated with different adult outcomes. Following Harrist et al. (1997), 558 kindergarten children (81% White, 17% Black) were categorized into one of the five groups: four clusters of social withdrawal (n = 95 unsociable, 23 passive-anxious, 18 active-isolate, and 25 sad/depressed) or non-withdrawal (n = 397), using directly observed school behavior and teacher ratings. About 30 years later (Mage = 34.45 years, SD = 0.62 years), participants self-reported on their romantic relationship and parent status and parenting warmth and harshness. Overall, the group of socially withdrawn children was no more or less likely than the non-withdrawn group to be in a current relationship or a parent, nor did they report any differences in parenting. However, the active-isolate subtype of social withdrawal, characterized by impulsivity and anger, was less likely than the non-withdrawn group to be in a current relationship (B = −1.24, p < 0.05). This study suggests socially withdrawn children in the United States fare similarly to non-withdrawn peers in adulthood in their romantic relationships and parenting, but a subgroup of active-isolate children may be at risk of not entering adult relationships.
Open Access
The association between cognitive function and subsequent depression: a systematic review and meta-analysis.
(Psychol Med, 2017-01) Scult, MA; Paulli, AR; Mazure, ES; Moffitt, TE; Hariri, AR; Strauman, TJ
Despite a growing interest in understanding the cognitive deficits associated with major depressive disorder (MDD), it is largely unknown whether such deficits exist before disorder onset or how they might influence the severity of subsequent illness. The purpose of the present study was to conduct a systematic review and meta-analysis of longitudinal datasets to determine whether cognitive function acts as a predictor of later MDD diagnosis or change in depression symptoms. Eligible studies included longitudinal designs with baseline measures of cognitive functioning, and later unipolar MDD diagnosis or symptom assessment. The systematic review identified 29 publications, representing 34 unique samples, and 121 749 participants, that met the inclusion/exclusion criteria. Quantitative meta-analysis demonstrated that higher cognitive function was associated with decreased levels of subsequent depression (r = -0.088, 95% confidence interval. -0.121 to -0.054, p < 0.001). However, sensitivity analyses revealed that this association is likely driven by concurrent depression symptoms at the time of cognitive assessment. Our review and meta-analysis indicate that the association between lower cognitive function and later depression is confounded by the presence of contemporaneous depression symptoms at the time of cognitive assessment. Thus, cognitive deficits predicting MDD likely represent deleterious effects of subclinical depression symptoms on performance rather than premorbid risk factors for disorder.