Browsing by Subject "magnetic resonance imaging (MRI)"

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    Corrigendum: Quantification of joint mobility limitation in adult type 1 diabetes.
    (Frontiers in endocrinology, 2023-01) Phatak, Sanat; Mahadevkar, Pranav; Chaudhari, Kaustubh Suresh; Chakladar, Shreya; Jain, Swasti; Dhadge, Smita; Jadhav, Sarita; Shah, Rohan; Bhalerao, Aboli; Patil, Anupama; Ingram, Jennifer L; Goel, Pranay; Yajnik, Chittaranjan S
    [This corrects the article DOI: 10.3389/fendo.2023.1238825.].
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    In Vivo Assessment of Exercise-Induced Glenohumeral Cartilage Strain.
    (Orthopaedic journal of sports medicine, 2018-07-13) Zhang, Hanci; Heckelman, Lauren N; Spritzer, Charles E; Owusu-Akyaw, Kwadwo A; Martin, John T; Taylor, Dean C; Moorman, CT; Garrigues, Grant E; DeFrate, Louis E
    The human shoulder joint is the most mobile joint in the body. While in vivo shoulder kinematics under minimally loaded conditions have been studied, it is unclear how glenohumeral cartilage responds to high-demand loaded exercise.A high-demand upper extremity exercise, push-ups, will induce compressive strain in the glenohumeral articular cartilage, which can be measured with validated magnetic resonance imaging (MRI)-based techniques.Descriptive laboratory study.High-resolution MRI was used to measure in vivo glenohumeral cartilage thickness before and after exercise among 8 study participants with no history of upper extremity injury or disease. Manual MRI segmentation and 3-dimensional modeling techniques were used to generate pre- and postexercise thickness maps of the humeral head and glenoid cartilage. Strain was calculated as the difference between pre- and postexercise cartilage thickness, normalized to the pre-exercise cartilage thickness.Significant compressive cartilage strains of 17% ± 6% and 15% ± 7% (mean ± 95% CI) were detected in the humeral head and glenoid cartilage, respectively. The anterior region of the glenoid cartilage experienced a significantly higher mean strain (19% ± 6%) than the posterior region of the glenoid cartilage (12% ± 8%). No significant regional differences in postexercise humeral head cartilage strain were observed.Push-ups induce compressive strain on the glenohumeral joint articular cartilage, particularly at the anterior glenoid. This MRI-based methodology can be applied to further the understanding of chondral changes in the shoulder under high-demand loading conditions.These results improve the understanding of healthy glenohumeral cartilage mechanics in response to loaded upper extremity exercise. In the future, these methods can be applied to identify which activities induce high glenohumeral cartilage strains and deviations from normal shoulder function.
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    Pulmonary Delivery of Therapeutic and Diagnostic Gases.
    (Journal of aerosol medicine and pulmonary drug delivery, 2018-04) Zapol, Warren M; Charles, H Cecil; Martin, Andrew R; Sá, Rui C; Yu, Binglan; Ichinose, Fumito; MacIntyre, Neil; Mammarappallil, Joseph; Moon, Richard; Chen, John Z; Geier, Eric T; Darquenne, Chantal; Prisk, G Kim; Katz, Ira
    The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session on Pulmonary Delivery of Therapeutic and Diagnostic Gases. The rationale for such a session within ISAM is that the pulmonary delivery of gaseous drugs in many cases targets the same therapeutic areas as aerosol drug delivery, and is in many scientific and technical aspects similar to aerosol drug delivery. This article serves as a report on the recent ISAM congress session providing a synopsis of each of the presentations. The topics covered are the conception, testing, and development of the use of nitric oxide to treat pulmonary hypertension; the use of realistic adult nasal replicas to evaluate the performance of pulsed oxygen delivery devices; an overview of several diagnostic gas modalities; and the use of inhaled oxygen as a proton magnetic resonance imaging (MRI) contrast agent for imaging temporal changes in the distribution of specific ventilation during recovery from bronchoconstriction. Themes common to these diverse applications of inhaled gases in medicine are discussed, along with future perspectives on development of therapeutic and diagnostic gases.