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Item Embargo Contests over Contraception in Late Twentieth-Century Mexico(2024) Gasparowicz, NatalieContests over Contraception in Late Twentieth-Century Mexico follows how the birth control pill became immoral and centers Mexican Catholics in this history. From the early 1960s to the early 1970s, Mexican Catholic bishops, priests, and married couples debated the morality of the pill. Because the pill was primarily a hormonal invention, as opposed to a barrier method, it inspired many questions and debates about the purpose of sex. In the 1960s, the Church was reevaluating its doctrine—including its approach to sex and marriage—amidst modernization, social change, and cultural upheaval. Instead of assuming a monolithic Mexican Church, Contests over Contraception centers on the diversity of Catholic actors and their ideas. I argue that at the heart of these pluralistic debates about the morality of the pill was the contested place of nonprocreative sex in marriage, otherwise known as conjugality, marital intimacy, and pleasure. My work places the question of marital intimacy at the center of these debates, unsettling many of the dominant narratives about the Church in Mexico and Latin America in this period: a critic of economic oppression or a defender of family values. Just as much as the very real economic circumstances led many Mexicans to be concerned with family size, this concern was not mutually exclusive with concerns over marital intimacy and pleasure, as often inadvertently assumed. The fear of couples resorting to abortion was powerful enough to reconcile many of these different concerns and push Mexican Catholics to consider approving the pill.This dissertation demonstrates that this history is much more than one of Catholic dissent or obedience in response to the Pope's prohibition of the pill in 1968. When we turn to Mexico, we see that these debates were about how couples, not individuals, made these decisions about their reproductive lives together. And so, marital intimacy—when and why couples should have sex and whether the pill could facilitate this process—was an important one. Concerns over economic circumstances only raised the stakes. This research suggests that the question of birth control is distinct from abortion, and invites a different set of questions, especially when studied in Mexico. Contemporary terminology used to discuss sexuality and reproduction (such as left/right or pro-life/pro-choice) did not apply to these complex debates in the 1960s. Centering on how Mexican Catholics conceived of conjugality, or pleasure between spouses, moves away from the equally important focus of individual rights and autonomy when discussing reproduction and sexuality. Historicizing how and when the pill became immoral in Mexico suggests reproductive matters were politicized at different rates across the world.
Item Open Access Evaluation of Age and Sex Differences in Contemporary versus High-Sensitivity Troponin I Measurement in Hospitalized Patients.(Journal of clinical medicine, 2024-04) Alkhalaileh, Hussam; Wei, Ruhan; Cordero Rivera, Ashly; Goksel, Mustafa; Lee, Jason KY; Mazzaferri, Ernest; Jones, JoAnna; Li, JieliBackground: With the transition from the contemporary (cTnI) to high-sensitivity troponin assay (hs-cTnI), concerns have arisen regarding the diagnostic differences between these two assays due to analytical distinctions. This study aims to evaluate the age and sex differences between these two assays, as well as the differences resulting from using two different 99th percentile values of the high-sensitivity troponin assay. Method: A retrospective observational study was conducted at an academic medical center, encompassing a total of 449 lithium heparin plasma samples included in the dataset. Both contemporary and high-sensitivity troponin were simultaneously measured using Siemens ADVIA Centaur analyzers. Two sets of sex-specific 99th percentile URLs from the Siemens study (cutoff-1) and Universal Sample Bank data (cutoff-2) were used for the data analysis. Results: The use of cutoff-1 or cutoff-2 had a negligible impact on troponin classification. Troponin elevation significantly increased in individuals > 50 years old for males and >40 years old for females, with both troponin assays. A receiver operating characteristic analysis did not find significant differences between the two assays. The Kaplan-Meier curves showed no differences in survival in cTnI according to the non-sex-specific 99th URL or hs-cTnI (cutoff-2) but showed a slight difference in survival in hs-cTnI (cutoff-1). Conclusions: Overall, there were no significant differences in age and sex in the diagnostic performance between the contemporary and high-sensitivity troponin assays. Selection criteria for the establishment of the 99th percentile URL should be standardized to avoid the misinterpretation of the troponin results.Item Open Access Free(dom)inated: A Feminist Examination of Hookup Culture’s Sexual Empowerment and Sexual Policing of Duke University Undergraduate Women(2017-05-05) Farless, HayleyHow do Duke University undergraduate women experience the seemingly empowering norms of hookup culture? While debate rages among feminists, scholars, journalists, and others as to whether or not hookup culture is beneficial for young women, this research offers a fresh perspective via an ethnographic examination of undergraduate women at Duke University in Durham, North Carolina, and how they experience hookup culture in a larger structure of male-privileged society. Based on interviews, qualitative surveys, and participant-observation on campus and at parties and bars, I explore the gendered elements of hookup culture and how they simultaneously sexually empower and oppress women at Duke’s campus. I argue that hookup culture polices women and their sexuality; that is, while hookup culture normalizes female participation in sex, it forces women into a prude–slut dichotomy. I then focus on the carnivalesque nightclub and the fraternity party as the primary sites where hookups are initiated, asserting that these spaces encourage female sexuality but also pressure women to objectify and commodify themselves. Finally, I consider the emerging, liminal space of the smartphone application Tinder and its gendered relation with hookup culture, in which women gain more control of the hookup space but are subjected to dehumanization and self-objectification. I argue that although the cultural norms of collegiate hookup culture seem to empower women’s expressions of sexuality by normalizing sexual activity for women, these same cultural norms actually contribute to Duke women’s sexual oppression by policing, objectifying, and commodifying female sexuality to serve male pleasure. This conclusion leads to a broader claim for future research: any degree of female sexual liberation that occurs within patriarchal society and male-privileging social structures only serves to placate women and perpetuate male sexual power.Item Open Access GIs and 'Jeep Girls': Sex and American Soldiers in Wartime China(Journal of Modern Chinese History, 2019) Fredman, ZachThis article examines how sex affected the larger politics of the Sino–US alliance during World War II. By early 1945, Chinese from across the social spectrum resented the US military presence, but just one issue sparked a violent backlash: sexual relations between American soldiers (GIs) and Chinese women. Two interrelated, patriarchal narratives about sex emerged that spring. Starting in March, government-backed newspapers began criticizing “Jeep girls,” an epithet coined to describe the Chinese women who consorted with American servicemen. Rumors also circulated that GIs were using Jeeps to kidnap “respectable” women and rape them. Each narrative portrayed women’s bodies as territory to be recovered and inextricable from national sovereignty. These narratives resonated widely, turning Jeep girls into the catalyst through which all variables causing resentment against the US military presence intersected and converged. With Japan on the ropes, China’s allied friends now stood in the way of irreversibly consigning foreign imperialism to the past. Sexual relations were not the Sino–US alliance’s seedy underside, but the core site of its tensions.Item Open Access Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.(Frontiers in genetics, 2018-01) Brummett, Beverly H; Babyak, Michael A; Singh, Abanish; Hauser, Elizabeth R; Jiang, Rong; Huffman, Kim M; Kraus, William E; Shah, Svati H; Siegler, Ilene C; Williams, Redford BThe serotonin receptor 5-HTR2C is thought to be involved in the function of multiple brain structures. Consequently, the HTR2C gene has been studied extensively with respect to its association with a variety of phenotypes. One coding variant in the HTR2C gene, Cys23Ser (rs6318), has been associated with depressive symptoms. and adiposity; however, these findings have been inconsistent. The reasons for this mixed picture may be due to low statistical power or due to other factors such as failure to account for possible interacting environmental factors, such as psychosocial stress. Further, the literature around this polymorphism is marked by limited inclusion of persons of African ancestry. The present study sought to overcome these limitations and definitively determine the relationship of this polymorphism with depressive and obesity phenotypes in a large sample meta-analysis. Thus, we harmonized individual level data from 10 studies including the Women's Health Initiative, CARDIA, ARIC, Framingham Offspring, and the Jackson Heart Study, resulting in a sample of 27,161 individuals (10,457 Black women, 2,819 Black men, 7,419 White women, and 6,466 White men). We conducted a random effects meta-analysis using individual level data to examine whether the Cys23Ser variant-either directly, or conditionally depending on the level of psychosocial stress-was associated with depressive symptoms and body mass index (BMI). We found that psychosocial stress was associated with both depression and BMI, but that Cys23Ser was not directly associated with, nor did it modify the associations of psychosocial stress with depression or BMI. Thus, in the largest study of this polymorphism, we have determined that rs6318 is not associated with depression, or BMI.Item Open Access Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction.(J Am Heart Assoc, 2017-03-20) Randolph, Tiffany C; Broderick, Samuel; Shaw, Linda K; Chiswell, Karen; Mentz, Robert J; Kutyifa, Valentina; Velazquez, Eric J; Gilliam, Francis R; Thomas, Kevin LBACKGROUND: Prolonged QRS duration is associated with increased mortality among heart failure patients, but race or sex differences in QRS duration and associated effect on outcomes are unknown. METHODS AND RESULTS: We investigated QRS duration and morphology among 2463 black and white patients with heart failure and left ventricular ejection fraction ≤35% who underwent coronary angiography and 12-lead electrocardiography at Duke University Hospital from 1995 through 2011. We used multivariable Cox regression models to assess the relationship between QRS duration and all-cause mortality and investigate race-QRS and sex-QRS duration interaction. Median QRS duration was 105 ms (interquartile range [IQR], 92-132) with variation by race and sex (P<0.001). QRS duration was longest in white men (111 ms; IQR, 98-139) followed by white women (108 ms; IQR, 92-140), black men (100 ms; IQR, 91-120), and black women (94 ms; IQR, 86-118). Left bundle branch block was more common in women than men (24% vs 14%) and in white (21%) versus black individuals (12%). In black patients, there was a 16% increase in risk of mortality for every 10 ms increase in QRS duration up to 112 ms (hazard ratio, 1.16; 95% CI, 1.07, 1.25) that was not present among white patients (interaction, P=0.06). CONCLUSIONS: Black individuals with heart failure had a shorter QRS duration and more often had non-left bundle branch block morphology than white patients. Women had left bundle branch block more commonly than men. Among black patients, modest QRS prolongation was associated with increased mortality.Item Open Access Telomeres and the natural lifespan limit in humans.(Aging (Albany NY), 2017-04) Steenstrup, Troels; Kark, Jeremy D; Verhulst, Simon; Thinggaard, Mikael; Hjelmborg, Jacob VB; Dalgård, Christine; Kyvik, Kirsten Ohm; Christiansen, Lene; Mangino, Massimo; Spector, Timothy D; Petersen, Inge; Kimura, Masayuki; Benetos, Athanase; Labat, Carlos; Sinnreich, Ronit; Hwang, Shih-Jen; Levy, Daniel; Hunt, Steven C; Fitzpatrick, Annette L; Chen, Wei; Berenson, Gerald S; Barbieri, Michelangela; Paolisso, Giuseppe; Gadalla, Shahinaz M; Savage, Sharon A; Christensen, Kaare; Yashin, Anatoliy I; Arbeev, Konstantin G; Aviv, AbrahamAn ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the 'telomeric brink', which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus, secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.