Duke Scholarly Works

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Open Access
9/11 Museum Should Not Conflate Islam and Terrorism
(Huffington Post, 2014-05-15) Schanzer, DH
Open Access
A Case for Quantifying Statistical Robustness of Specialized Probabilistic AI Accelerators
(2019 IBM IEEE CAS/EDS – AI Compute Symposium, 2019-10-02) Zhang, Xiangyu; Mukherjee, Sayan; Lebeck, Alvin
Open Access
A Christmas Story -Septic Tank Drowning/Aspiration
(Case Studies in Emergency Medicine) Severance, Harry
Open Access
A Common Stage: Theater and Public Life in Medieval Arras
(2010) Solterer, Helen
Open Access
A Comparison of the Wellbeing of Orphans and Abandoned Children Ages 6-12 in Institutional and Community-Based Care Settings in 5 Less Wealthy Nations
(2009) Whetten, Kathryn; Ostermann, Jan; Whetten, Rachel A; Pence, Brian W; O'Donnell, Karen; Messer, Lynne C; Thielman, Nathan M; Positive Outcomes for Orphans (POFO) Research Team
Background: Leaders are struggling to care for the estimated 143,000,000 orphans and millions more abandoned children worldwide. Global policy makers are advocating that institution-living orphans and abandoned children (OAC) be moved as quickly as possible to a residential family setting and that institutional care be used as a last resort. This analysis tests the hypothesis that institutional care for OAC aged 6-12 is associated with worse health and wellbeing than community residential care using conservative two-tail tests. Methodology: The Positive Outcomes for Orphans (POFO) study employed two-stage random sampling survey methodology in 6 sites across 5 countries to identify 1,357 institution-living and 1,480 community-living OAC ages 6-12, 658 of whom were double-orphans or abandoned by both biological parents. Survey analytic techniques were used to compare cognitive functioning, emotion, behavior, physical health, and growth. Linear mixed-effects models were used to estimate the proportion of variability in child outcomes attributable to the study site, care setting, and child levels and institutional versus community care settings. Conservative analyses limited the community living children to double-orphans or abandoned children. Principal Findings: Health, emotional and cognitive functioning, and physical growth were no worse for institution-living than community-living OAC, and generally better than for community-living OAC cared for by persons other than a biological parent. Differences between study sites explained 2-23% of the total variability in child outcomes, while differences between care settings within sites explained 8-21%. Differences among children within care settings explained 64-87%. After adjusting for sites, age, and gender, institution vs. community-living explained only 0.3-7% of the variability in child outcomes. Conclusion: This study does not support the hypothesis that institutional care is systematically associated with poorer wellbeing than community care for OAC aged 6-12 in those countries facing the greatest OAC burden. Much greater variability among children within care settings was observed than among care settings type. Methodologically rigorous studies must be conducted in those countries facing the new OAC epidemic in order to understand which characteristics of care promote child wellbeing. Such characteristics may transcend the structural definitions of institutions or family homes.
Open Access
A computational screen for site selective A-to-I editing detects novel sites in neuron specific Hu proteins
(2010) Ensterö, Mats; Akerborg, Orjan; Lundin, Daniel; Wang, Bei; Furey, Terrence S; Ohman, Marie; Lagergren, Jens
Background: Several bioinformatic approaches have previously been used to find novel sites of ADAR mediated A-to-I RNA editing in human. These studies have discovered thousands of genes that are hyper-edited in their non-coding intronic regions, especially in alu retrotransposable elements, but very few substrates that are site-selectively edited in coding regions. Known RNA edited substrates suggest, however, that site selective A-to-I editing is particularly important for normal brain development in mammals. Results: We have compiled a screen that enables the identification of new sites of site-selective editing, primarily in coding sequences. To avoid hyper-edited repeat regions, we applied our screen to the alu-free mouse genome. Focusing on the mouse also facilitated better experimental verification. To identify candidate sites of RNA editing, we first performed an explorative screen based on RNA structure and genomic sequence conservation. We further evaluated the results of the explorative screen by determining which transcripts were enriched for A-G mismatches between the genomic template and the expressed sequence since the editing product, inosine (I), is read as guanosine (G) by the translational machinery. For expressed sequences, we only considered coding regions to focus entirely on re-coding events. Lastly, we refined the results from the explorative screen using a novel scoring scheme based on characteristics for known A-to-I edited sites. The extent of editing in the final candidate genes was verified using total RNA from mouse brain and 454 sequencing. Conclusions: Using this method, we identified and confirmed efficient editing at one site in the Gabra3 gene. Editing was also verified at several other novel sites within candidates predicted to be edited. Five of these sites are situated in genes coding for the neuron-specific RNA binding proteins HuB and HuD.
Open Access
A Delegation-Based Theory of Expertise
(American Economic Journal: Microeconomics, 2021-11-01) Ambrus, Attila; Baranovskyi, Volodymyr; Kolb, Aaron
We investigate information aggregation and competition in a delegation framework. An uninformed principal is unable to perform a task herself and must choose between one of two biased and imperfectly informed experts. In the focal equilibrium, experts exaggerate their biases, anticipating an ideological winner's curse. We show that having a second expert can benefit the principal, even when equally or more biased than the first expert. The principal can benefit from commitment to an "element of surprise" and prefers experts with equal rather than opposite biases.
Open Access
A Generalizable Scale of Propensity to Plan: The Long and the Short of Planning for Time and for Money
(2010) Lynch, John G; Netemeyer, Richard G; Spiller, Stephen A; Zammit, Alessandra
Planning has pronounced effects on consumer behavior and intertemporal choice. We develop a six-item scale measuring individual differences in propensity to plan that can be adapted to different domains and used to compare planning across domains and time horizons. Adaptations tailored to planning time and money in the short run and long run each show strong evidence of reliability and validity. We find that propensity to plan is moderately domain-specific. Scale measures and actual planning measures show that for time, people plan much more for the short run than the long run; for money, short- and long-run planning differ less. Time and money adaptations of our scale exhibit sharp differences in nomological correlates; short- run and long-run adaptations differ less. Domain-specific adaptations predict frequency of actual planning in their respective domains. A "very long-run" money adaptation predicts FICO credit scores; low planners thus face materially higher cost of credit.
Open Access
A Guide to Municipal Water Conservation Pricing in Utah
(Utah State University Extension Fact Sheet, 2019-01-01) Sutherland, Sara; Edwards, Eric
Open Access
A Man with No Religion
(2012-02-06) Strandberg, Victor
Open Access
A modular simulation system for the bidomain equations
Pormann, J
Cardiac arrhythmias and fibrillation are potentially life threatening diseases that can result from the improper conduction of electrical impulses in the heart. Experimental study of such cardiac abnormalities are dangerous at best, often requiring the subject to be placed in fibrillation for some time before attempting a large ``rescue'' shock. Thus, most all studies are done in animals and not humans. Furthermore, there is some indication that heart size may have considerable implications for fibrillation and other conduction abnormalities. Thus animal models for defibrillation studies must be chosen with great care. As an alternative, researchers are now using computer simulation to study the factors that generate and sustain arrhythmias, hoping to obtain at least preliminary data to guide fewer, more targeted experimental studies. Computer simulations of the Bidomain Equations have become very complex as they have been applied to many problems in cardiac electrophysiology. More complex membrane dynamics, irregular grids, and 3-D data sets are all being investigated. Software engineering principles will need to be applied to manage this continuing growth in complexity. We propose a modular framework for development of a Simulation System whereby a researcher may mix and match program elements to generate a simulator tailored to their particular problem. The modular approach will simplify the generation and maintenance of the different program elements and it will enable the end-researcher to determine the proper mix of complexity versus speed for their particular problem of interest. The contrary approach, one monolithic program which can run all simulations of all complexities, is simply unrealistic. It would impose too great a burden on maintenance and upgradability, and it would be difficult to provide good performance for a wide range of applications. The modular approach also allows for the incremental inclusion of various complexities in the bidomain model. From a simple 2-D homogeneous, isotropic regular grid, monodomain simulation, we can progress, step by step, to a bidomain simulation with a fully implicit time-integration scheme on irregular, 3-D grids with arbitrary anisotropy and inhomogeneity, with a non-trivial membrane model. Simulations with such a wealth of complexity have not been performed to date. As microprocessors have become cheaper and more powerful, parallel computing has become more widespread. Machines with hundreds of high-performance CPUs connected by fast networks are commonplace and are now capable of surpassing traditional vector-based supercomputers in terms of overall performance. The Simulation System presented here incorporates data-parallelism to allow large scale Bidomain problems to be run on these newest parallel supercomputers. The large amount of distributed memory in such machines can be harnessed to allow extremely large scale simulations to be run. The large number of CPUs provide a tremendous amount of computational power which can be used to run such simulations more quickly. Finally, the results presented here show that a modular Simulation System is feasible for a wide range of pplications, and that it can obtain very good performance over this range of applications. The parallel speed-up seen was very good, regularly achieving a factor of 13 speed-up on 16 processors. The results presented here also show that we can simulate bidomain problems using an implicit time-integrator with an irregular, anisotropic and inhomogeneous, grid and a non-trivial membrane model. We are able to run such simulations on parallel computers, thereby harnessing a tremendous amount of memory and computational resources. Such simulations have not been run to date.
Open Access
A National COVID-19 Surveillance System: Achieving Containment
(2020-04-07) McClellan, Mark; Gottlieb, Scott; Mostashari, Farzad; Rivers, Caitlin; Silvis, Lauren
Open Access
A Note on Two Dynastic Monuments in the Thirteenth Century: St.-Denis and Sta. Maria Iconavetere in Foggia
(IVISTA D'ARTE (V serie). Periodico Internazionale di Storia dell'Arte Medievale e Moderna 2017 ~ a. 52 n. 7 Mélanges à Fabienne Joubert) Bruzelius, Caroline
In the thirteenth century the structures of royal and imperial monuments reflected the importance of dynastic memorials.
Open Access
A Philosophy of Operatic Storytelling
(2016) Penner, N
This dissertation presents the first theoretical model for understanding narration and point of view in opera, examining repertoire from Richard Wagner to Benjamin Britten. Prior music scholarship on musical narratives and narrativity has drawn primarily on continental literary theory and philosophy of the 1960s to the middle of the 1980s. This study, by contrast, engages with current debates in the analytic branch of aesthetic philosophy. One reason why the concept of point of view has not been more extensively explored in opera studies is the widespread belief that operas are not narratives. This study questions key premises on which this assumption rests. In so doing, it presents a new definition of narrative. Arguably, a narrative is an utterance intended to communicate a story, where "story" is understood to involve the representation of a particular agent or agents exercising their agency. This study explores the role of narrators in opera, introducing the first taxonomy of explicit fictional operatic narrators. Through a close analysis of Britten and Myfanwy Piper's Owen Wingrave, it offers an explanation of music's power to orient spectators to the points of view of opera characters by providing audiences with access to characters' perceptual experiences and cognitive, affective, and psychological states. My analysis also helps account for how our subjective access to fictional characters may engender sympathy for them. The second half of the dissertation focuses on opera in performance. Current thinking in music scholarship predominantly holds that fidelity is an outmoded concern. I argue that performing a work-for-performance is a matter of intentionally modelling one's performance on the work-for-performance's features and achieving a moderate degree of fidelity or matching between the two. Finally, this study investigates how the creative decisions of the performers and director impact the point of view from which an opera is told.
Open Access
A Randomized Trial of Protocol-Based Care for Early Septic Shock
(New England Journal of Medicine, 2014-05) ProCESS Investigators; Yealy, Donald M; Kellum, John A; Huang, David T; Barnato, Amber E; Weissfeld, Lisa A; Pike, Francis; Terndrup, Thomas; Wang, Henry E; Hou, Peter C; LoVecchio, Frank; Filbin, Michael R; Shapiro, Nathan I; Angus, Derek C
Open Access
A sensible debate about radical Islam
(Atlanta Journal Constitution, 2011-02-10) Schanzer, DH
Open Access
Achieving Widespread Availability of Timely and Efficient COVID-19 Testing
(2020-03-26) McClellan, Mark; Gottlieb, Scott
Open Access
Acting Like Americans on Ramadan
(Huffington Post, 2012-07-20) Schanzer, DH
Open Access
Active-Space N-Representability Constraints for Variational Two-Particle Reduced Density Matrix Calculations
(2010) Shenvi, Neil; Izmaylov, Artur F
The ground-state energy of a system of fermions can be calculated by minimizing a linear functional of the two-particle reduced density matrix (2-RDM) if an accurate set of N-representability conditions is applied. In this Letter we introduce a class of linear N-representability conditions based on exact calculations on a reduced active space. Unlike wave-function-based approaches, the 2-RDM methodology allows us to combine information from calculations on different active spaces. By adding active-space constraints, we can iteratively improve our estimate for the ground-state energy. Applying our methodology to a 1D Hubbard model yields a significant improvement over traditional 2-positivity constraints with the same computational scaling.
Open Access
Adelante el pasado: oralidad y visualidad, acto y evento en la prácticas artísticas del mundo indígena contemporáneo
(Revista Kaypunku: Estudios Interdisciplinarios de Arte y Cultura, 2019-06-03) Rojas Sotelo, Miguel
El presente artículo es un ejercicio de lectura de la producción de dos cultores visuales del mundo indígena de Abya Yala: Rosa Tisoy-Tandioy, artista inga de Colombia, y Benvenuto Chavajay, artista maya de Guatemala. Mediante su práctica artística cargada de visualidad y acciones-eventos presentan estrategias conceptuales cercanas al llamado giro de(s)colonial, que dan cuenta de sus experiencias como creadores contemporáneos en Latinoamérica.