Browsing by Author "Boyce, Michael"

Now showing items 21-26 of 26

    • O-GlcNAcylation of master growth repressor DELLA by SECRET AGENT modulates multiple signaling pathways in Arabidopsis. 

      Zentella, Rodolfo; Hu, Jianhong; Hsieh, Wen-Ping; Matsumoto, Peter A; Dawdy, Andrew; Barnhill, Benjamin; Oldenhof, Harriëtte; ... (16 authors) (Genes & development, 2016-01)
      The DELLA family of transcription regulators functions as master growth repressors in plants by inhibiting phytohormone gibberellin (GA) signaling in response to developmental and environmental cues. DELLAs also play a central ...

    • Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton. 

      Tarbet, Heather J; Dolat, Lee; Smith, Timothy J; Condon, Brett M; O'Brien, E Timothy; Valdivia, Raphael H; Boyce, Michael (eLife, 2018-03-07)
      Intermediate filaments (IF) are a major component of the metazoan cytoskeleton and are essential for normal cell morphology, motility, and signal transduction. Dysregulation of IFs causes a wide range of human diseases, ...

    • Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. 

      Toleman, Clifford A; Schumacher, Maria A; Yu, Seok-Ho; Zeng, Wenjie; Cox, Nathan J; Smith, Timothy J; Soderblom, Erik J; ... (10 authors) (Proceedings of the National Academy of Sciences of the United States of America, 2018-06)
      O-GlcNAc is an intracellular posttranslational modification that governs myriad cell biological processes and is dysregulated in human diseases. Despite this broad pathophysiological significance, the biochemical effects ...

    • Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. 

      Long, Kai; Boyce, Michael; Lin, He; Yuan, Junying; Ma, Dawei (Bioorganic & medicinal chemistry letters, 2005-09)
      The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl ...

    • The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA. 

      Zentella, Rodolfo; Sui, Ning; Barnhill, Benjamin; Hsieh, Wen-Ping; Hu, Jianhong; Shabanowitz, Jeffrey; Boyce, Michael; ... (11 authors) (Nat Chem Biol, 2017-05)
      Plant development requires coordination among complex signaling networks to enhance the plant's adaptation to changing environments. DELLAs, transcription regulators originally identified as repressors of phytohormone gibberellin ...

    • The human UDP-galactose 4'-epimerase (GALE) is required for cell-surface glycome structure and function. 

      Broussard, Alex; Florwick, Alyssa; Desbiens, Chelsea; Nischan, Nicole; Robertson, Corrina; Guan, Ziqiang; Kohler, Jennifer J; ... (9 authors) (The Journal of biological chemistry, 2019-12-09)
      Glycan biosynthesis relies on nucleotidesugars (NS), abundant metabolites that serve as monosaccharide donors for glycosyltransferases. In vivo, signal-dependent fluctuations in NS levels are required to maintain normal ...