Browsing by Author "Henao, Ricardo"
Now showing items 21-40 of 40
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Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion.
(Res Sq, 2022-04-07)SARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease ... -
Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test.
(Critical care medicine, 2021-10)<h4>Objectives</h4>Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and ... -
Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approaches.
(medRxiv, 2020-07-26)In order to elucidate novel aspects of the host response to SARS-CoV-2 we performed RNA sequencing on peripheral blood samples across 77 timepoints from 46 subjects with COVID-19 and compared them to subjects with seasonal ... -
Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.
(Nature communications, 2021-02-17)SARS-CoV-2 infection has been shown to trigger a wide spectrum of immune responses and clinical manifestations in human hosts. Here, we sought to elucidate novel aspects of the host response to SARS-CoV-2 infection through ... -
Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease.
(Hepatology (Baltimore, Md.), 2021-03-16)<h4>Background and aims</h4>Whether glycemic control, as opposed to diabetes status, is associated with the severity of nonalcoholic fatty liver disease (NAFLD) is unknown. We aimed to evaluate whether degree of glycemic ... -
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ... -
Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression.
(Cellular and molecular gastroenterology and hepatology, 2020-01)<h4>Background & aims</h4>Nonalcoholic steatohepatitis (NASH) occurs in the context of aberrant metabolism. Glutaminolysis is required for metabolic reprograming of hepatic stellate cells (HSCs) and liver fibrogenesis in ... -
Malignancy Prediction and Lesion Identification from Clinical Dermatological Images.
(CoRR, 2021)We consider machine-learning-based malignancy prediction and lesion identification from clinical dermatological images, which can be indistinctly acquired via smartphone or dermoscopy capture. Additionally, we do not assume that ... -
Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection.
(EBioMedicine, 2017-03)Infection of respiratory mucosa with viral pathogens triggers complex immunologic events in the affected host. We sought to characterize this response through proteomic analysis of nasopharyngeal lavage in human subjects ... -
Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.
(PloS one, 2019-01)BACKGROUND:The heart is a metabolically active organ, and plasma acylcarnitines are associated with long-term risk for myocardial infarction. We hypothesized that myocardial ischemia from cardiac stress testing will produce ... -
Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.
(Open forum infectious diseases, 2020-06)Background:Pathogen-based diagnostics for acute respiratory infection (ARI) have limited ability to detect etiology of illness. We previously showed that peripheral blood-based host gene expression classifiers accurately ... -
Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection.
(JAMA network open, 2022-04)<h4>Importance</h4>Bacterial and viral causes of acute respiratory illness (ARI) are difficult to clinically distinguish, resulting in the inappropriate use of antibacterial therapy. The use of a host gene expression-based ... -
Rapid, Sample-to-Answer Host Gene Expression Test to Diagnose Viral Infection
(Open Forum Infectious Diseases, 2019-11-01)<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Distinguishing bacterial, viral, or other etiologies of acute illness is diagnostically ... -
Systematic comparison of published host gene expression signatures for bacterial/viral discrimination.
(Genome medicine, 2022-02-21)<h4>Background</h4>Measuring host gene expression is a promising diagnostic strategy to discriminate bacterial and viral infections. Multiple signatures of varying size, complexity, and target populations have been described. ... -
Telehealth Made EASY: Understanding Provider Perceptions of Telehealth Appropriateness in Outpatient Rheumatology Encounters.
(ACR open rheumatology, 2022-07-19)<h4>Objective</h4>The purpose of this study was to evaluate a novel scoring system, the Encounter Appropriateness Score for You (EASY), to assess provider perceptions of telehealth appropriateness in rheumatology ... -
The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood.
(Frontiers in immunology, 2021-01)Viruses cause a wide spectrum of clinical disease, the majority being acute respiratory infections (ARI). In most cases, ARI symptoms are similar for different viruses although severity can be variable. The objective of ... -
The host transcriptional response to Candidemia is dominated by neutrophil activation and heme biosynthesis and supports novel diagnostic approaches.
(Genome medicine, 2021-07)<h4>Background</h4>Candidemia is one of the most common nosocomial bloodstream infections in the United States, causing significant morbidity and mortality in hospitalized patients, but the breadth of the host response to ... -
Thyroid Cancer Malignancy Prediction From Whole Slide Cytopathology Images
We consider preoperative prediction of thyroid cancer based on ultra-high-resolution whole-slide cytopathology images. Inspired by how human experts perform diagnosis, our approach first identifies and classifies diagnostic ... -
Validation of a Host Gene Expression Test for Bacterial/Viral Discrimination in Immunocompromised Hosts.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-08)<h4>Background</h4>Host gene expression has emerged as a complementary strategy to pathogen detection tests for the discrimination of bacterial and viral infection. The impact of immunocompromise on host-response tests remains ... -
Validation of a host response test to distinguish bacterial and viral respiratory infection.
(EBioMedicine, 2019-10-17)BACKGROUND:Distinguishing bacterial and viral respiratory infections is challenging. Novel diagnostics based on differential host gene expression patterns are promising but have not been translated to a clinical platform ...
