Browsing by Author "McClain, Micah T"
Now showing items 21-28 of 28
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Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.
(Open forum infectious diseases, 2020-06)Background:Pathogen-based diagnostics for acute respiratory infection (ARI) have limited ability to detect etiology of illness. We previously showed that peripheral blood-based host gene expression classifiers accurately ... -
Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection.
(JAMA network open, 2022-04)<h4>Importance</h4>Bacterial and viral causes of acute respiratory illness (ARI) are difficult to clinically distinguish, resulting in the inappropriate use of antibacterial therapy. The use of a host gene expression-based ... -
Systematic comparison of published host gene expression signatures for bacterial/viral discrimination.
(Genome medicine, 2022-02-21)<h4>Background</h4>Measuring host gene expression is a promising diagnostic strategy to discriminate bacterial and viral infections. Multiple signatures of varying size, complexity, and target populations have been described. ... -
Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.
(PLoS Genet, 2011-08)Exposure to influenza viruses is necessary, but not sufficient, for healthy human hosts to develop symptomatic illness. The host response is an important determinant of disease progression. In order to delineate host molecular ... -
The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood.
(Frontiers in immunology, 2021-01)Viruses cause a wide spectrum of clinical disease, the majority being acute respiratory infections (ARI). In most cases, ARI symptoms are similar for different viruses although severity can be variable. The objective of ... -
Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans.
(J Infect Dis, 2016-05-01)BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause of diarrhea. Though usually self-limited, it can be severe and debilitating. Little is known about the host transcriptional response to infection. ... -
Validation of a Host Gene Expression Test for Bacterial/Viral Discrimination in Immunocompromised Hosts.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-08)<h4>Background</h4>Host gene expression has emerged as a complementary strategy to pathogen detection tests for the discrimination of bacterial and viral infection. The impact of immunocompromise on host-response tests remains ... -
Validation of a host response test to distinguish bacterial and viral respiratory infection.
(EBioMedicine, 2019-10-17)BACKGROUND:Distinguishing bacterial and viral respiratory infections is challenging. Novel diagnostics based on differential host gene expression patterns are promising but have not been translated to a clinical platform ...
