Browsing by Department "Chemistry"
Now showing items 21-40 of 254
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Characterization and Applications of Force-induced Reactions
(2015)Just as heat, light and electricity do, mechanical forces can also stimulate reactions. Conventionally, these processes - known as mechanochemistry - were viewed as comprising only destructive events, such as bond scission ... -
Characterization of Metal Binding Peptides Derived from Copper Trafficking Proteins
(2010)Copper was first released into the environment as the result of the mass generation of oxygen from photosynthetic bacteria roughly 2.7 billion years ago. While it proved to be poisonous to early life on Earth, those that ... -
Characterizing the Mechanical Strengths of Chemical Bonds via Sonochemical Polymer Mechanochemistry
(2015)Mechanically induced chemical bond scission underlies the fracture and macroscopic failure of polymeric materials. Thus, the mechanical strength of scissile chemical bonds plays a role in material failure and in the mechanical ... -
Characterizing the Physiochemical Properties of Copper Chelating Agents: an Effort Towards Understanding their Antifungal Activity
(2015)An increase in drug-resistant infections and the paucity of new antibiotics present a major world health problem. Cryptococcus neoformans (C. neoformans) is an opportunistic fungal pathogen responsible for life-threatening ... -
Charge Transfer and Energy Transfer: Methods Development and Applications in Bio-molecular Systems
(2017)System-environment interactions are essential in determining charge-transfer (CT) rates and mechanisms. We developed a computationally accessiblemethod, suitable to simulate CT in flexible molecules (i.e., DNA) with hundreds ... -
Chemical and Physical Analysis of Melanin in Complex Biological Matrices
(2014)Melanin is a ubiquitous biological pigment found in bacteria, fungi, plants, and animals. It has a diverse range of ecological and biochemical functions including display, evasion, photoprotection, detoxification, and metal ... -
Chemical Biology Approaches to Combat Parkinson’s Disease
(2018)Parkinson's disease (PD) is a debilitating neurodegenerative disease of the central nervous system characterized by loss of striatal dopaminergic projections from the substantia nigra. Although there is no known cure for ... -
Chemical biology approaches to probe protein networks for alleviation of trafficking defects in Parkinson’s disease
(2021)Parkinson’s disease (PD), a common neurodegenerative disorder, can result from defective proteostasis mechanisms that induce neuronal toxicity. A common pathological hallmark of PD is the disruption of protein transport ... -
Chemical Reactions and Self-assembly in Nano-confined Environments: the Development of New Catalytic Microcontact Printing Techniques and Multicomponent Inorganic Janus Particles
(2009)Modern patterning and fabrication techniques provide powerful opportunities for the preparation of micro- and nanostructured objects with applications in fields ranging from drug delivery and bioimaging to organic based ... -
Control and Characterization of Electron Transfer with Vibrational Excitations
(2018)The interactions between electronic dynamics and the molecular vibrations in a donor-‐‑bridge-‐‑acceptor (DBA) structure lie at the core of electron transfer (ET) reactions mechanisms. Aiming to control and characterize ... -
Controlling and Exploiting Spiropyran-based Mechanochromism
(2019)When mechanical force is applied to synthetic materials, polymer chains becomehighly strained, leading to bond scission and ultimately material failure. Over the lastdecade or so, work in the field of polymer mechanochemistry ... -
Copper as an Antibacterial Agent and Disruptor of Protein Stability
(2020)The emergence of resistance to existing antibiotic drugs necessitates the development of new strategies to treat bacterial infections. Copper (Cu) has been used since ancient times to inhibit bacterial growth and has recently ... -
Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition
(2010)Mechanisms of copper homeostasis are of great interest partly due to their connection to debilitating genetic and neurological disorders. The family of high-affinity copper transporters (Ctr) is responsible for extracellular ... -
Copper-Based Nanowires for Printable Memory and Stretchable Conductors
(2018)In the field of electronic materials, metal nanowires have been extensively studied for both their syntheses and their properties in electronic composites and devices. This dissertation addresses challenges in the field ... -
Copper-Catalyzed Amino Oxygenation of Alkenes and Dienes: A Novel Amino-Initiation Pathway Using O-Benzoylhydroxylamines
(2018)Nitrogen-containing compounds, specifically the 1,2-oxyamino moiety, are of vital importance to modern pharmaceuticals, natural products, and agrochemicals. 1,2-Difunctionalization of alkenes offers an efficient approach ... -
Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C-H Bonds
(2015)The wide presence of C-N bonds in biologically and pharmaceutically important compounds continues to drive the development of new C-N bond-forming transformations. Among the different strategies, electrophilic amination ... -
Covalent mechanochemistry of four-membered carbocycles
(2021)The development of multi-mechanophore polymers (MMPs) has empowered new methodologies for observing and quantifying mechanochemical transformations. Previously developed techniques such as single-molecule force spectroscopy ... -
Deciphering and Leveraging Prominent Features of RNA-Targeting Small Molecules
(2021)Non-coding RNAs (ncRNAs) are a newly discovered class of biomolecules implicated in biological processes and disease pathogenesis. Small molecules have been proven to be a viable avenue to study biologically relevant ncRNAs; ... -
Density Functional and Ab Initio Study of Molecular Response
(2014)Quantum chemistry methods nowadays reach its maturity with various robust ground state correlation methods. However, many problems related to response do not have satisfactory solutions. Chemical reactivity indexes are some ... -
Design and Assembly of Hybrid Nanomaterial Systems for Energy Storage and Conversion
(2013)Energy storage systems are critically important for many areas in modern society including consumer electronics, transportation and renewable energy production. This dissertation summarizes our efforts on improving ...
