Browsing by Subject "Cellular biology"
Now showing items 21-40 of 219
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Cardiac Mitogen Signaling During Zebrafish Heart Regeneration
(2020)AbstractAdult zebrafish demonstrate a remarkable capacity to regenerate heart tissue following injury, and thus have served as a valuable model for developing our understanding of cardiac repair and regeneration. Recent ... -
Cell Lineage Specification during Mouse Embryonic Gonad Development
(2017)The mouse embryonic gonad provides an outstanding model to study the complex mechanisms involved in cell fate specification and maintenance. At the bipotential stage, both XX and XY gonads are capable of becoming testes ... -
Cell-cycle Dependent Regulation of Telomere-Associate Proteins
(2013)Telomeres are protein-DNA structures at the ends of eukaryotic chromosomes. The DNA portion is comprised of double-stranded and single-stranded G-rich repetitive DNA. The protein portion is anchored by the "shelterin complex" ... -
Cellular and Molecular Mechanisms of Cardiac Chamber Maturation in Zebrafish
(2018)The formation of the heart is a critical part of development that, if defective, can lead to congenital malformations incompatible with life. An improved understanding of the cellular and molecular processes that build the ... -
Cellular and Molecular Mediators of Bronchiolitis Obliterans-like Pathological Changes in a Murine Model of Chlorine Gas Inhalation
(2013)Bronchiolitis Obliterans (BO) is a major cause of chronic airway dysfunction after toxic chemical inhalation. The pathophysiology of BO is not well understood, but epithelial cell injury has been closely associated with ... -
Cellular Mechanism of Obsessive-Compulsive Disorder
(2015)Obsessive-compulsive disorder (OCD) is a devastating illness that afflicts around 2% of the world's population with recurrent distressing thoughts (obsessions) and repetitive ritualistic behaviors (compulsions). ... -
Cellular Mechanisms Regulating Single Lumen Formation in the Zebrafish Gut
(2014)The formation of a single lumen during tubulogenesis is crucial for the development and function of many organs. Although 3D cell culture models have identified molecular mechanisms controlling lumen formation in vitro, ... -
Characterization of the Role of Transferrin receptor 1 (Tfr1) in the Intestinal Epithelium, Pancreas and Skin
(2015)Transferrin receptor 1 (Tfr1) serves as a receptor for transferrin, an iron-binding protein in the blood, in its canonical role of iron assimilation. Tfr1 is expressed ubiquitously in many tissues and is believed to be ... -
Characterizing the Role of the Previously Undescribed Protein Caskin2 in Vascular Biology
(2016)Maintenance of vascular homeostasis is an active process that is dependent on continuous signaling by the quiescent endothelial cells (ECs) that line mature vessels. Defects in vascular homeostasis contribute to numerous ... -
Chemical Biology Approaches to Combat Parkinson’s Disease
(2018)Parkinson's disease (PD) is a debilitating neurodegenerative disease of the central nervous system characterized by loss of striatal dopaminergic projections from the substantia nigra. Although there is no known cure for ... -
Chromatin Accessibility Dynamics Underlying Development and Disease
(2015)Despite a largely static DNA sequence, our genomes are incredibly malleable. Comparative studies of chromatin features between different cell types, tissues, and species have revealed tremendous differences in how the genome ... -
Clonal Analysis of the Zebrafish Fin Regeneration Blastema
(2016)Regeneration is a remarkable feat of developmental regrowth and patterning. The blastema is a mass of progenitor cells that enables complete regeneration of amputated salamander limbs or fish fins. Despite years of study, ... -
Clonal Studies of Human B Cells
(2015)B lymphocytes are multifunctional and play important roles in both innate and adaptive immunity. The diverse roles of B cells can be attributed to the various and distinct types of B cells as determined by their origin, ... -
Computational Systems Biology of Saccharomyces cerevisiae Cell Growth and Division
(2014)Cell division and growth are complex processes fundamental to all living organisms. In the budding yeast, <italic>Saccharomyces cerevisiae</italic>, these two processes are known to be coordinated with one another as a cell's ... -
Control of Nucleotide-Sugar Metabolism in Glycan Biosynthesis and Cellular Physiology
(2019)Glycosylation is a universally conserved and ubiquitous posttranslational modification required for myriad cellular processes. Biosynthesis of these moieties, termed glycans, relies on nucleotide-sugars (NS), abundant metabolites ... -
Cooption of Innate Immune Cells in Promoting and Combating Infections
(2018)The key components of innate immune defense to pathogens are various migratory as well as tissue resident innate immune cells, however, their interactions with pathogens as well as their immune-orchestrating roles are often ... -
Coupling of the Yeast Metabolic Cycle and the Cell Division Cycle in Populations and Single Cells
(2017)Biological oscillators are ubiquitous in living systems. They allow cellular processes to anticipate and act in synchrony with regular events in the outside world (such as the day/night cycle), or they ensure that processes ... -
Cytoskeletal Dynamics and the Temporal Control of Yeast Morphogenesis
(2012)The cells of the budding yeast Saccharomyces cerevisiae undergo a robust morphological cycle, involving reorganization of the actin cytoskeleton, septin ring formation, and polarized growth. These events are crucial to ... -
Cytoskeletal Networks Driving Presynaptic Plasticity
(2021)Synapses – the delicate connections between our neurons – adjust and refine their strength to shape our brains, our thoughts, and our memories. Proteomic and genetic techniques have revealed that this process, known as synaptic ... -
Death and the Construction of an Astrocyte Network
(2019)Naturally-occurring cell death is a fundamental developmental mechanism for regulating cell numbers and sculpting developing organs. This is particularly true in the central nervous system, where large numbers of neurons ...
