Browsing by Subject "Disease Progression"

Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change.

Kraus, Virginia; Roemer, Frank W; Guermazi, Ali; Collins, Jamie E; Losina, Elena; Nevitt, Michael C; Lynch, John A; ... (10 authors) (BMC musculoskeletal disorders, 2016-11-10)

To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes ...

Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT-AF Registry.

Chang, P; Fonarow, GC; Freeman, J; Gersh, Bernard John; Go, AS; Jackson, Larry Ronald II; Kim, SH; ... (14 authors) (Clin Cardiol, 2016-02)

BACKGROUND: Patients with sinus node dysfunction (SND) have increased risk of atrial tachyarrhythmias, including atrial fibrillation (AF). To date, treatment patterns and outcomes of patients with SND and AF have not been ...

The relationship between blood IL-12p40 level and melanoma progression.

Fang, S; Wang, Y; Chun, YS; Liu, H; Ross, MI; Gershenwald, JE; Cormier, JN; ... (17 authors) (Int J Cancer, 2015-04-15)

Cytokines such as Interleukin (IL)-12p70 ("IL-12") and IL-23 can influence tumor progression. We tested the hypothesis that blood levels of IL-12p40, the common subunit of both cytokines, are associated with melanoma progression. ...

Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.

Souma, Tomokazu; Nezu, Masahiro; Yu, Lei; Suzuki, Takafumi; Saigusa, Daisuke; Ito, Sadayoshi; Suzuki, Norio; ... (8 authors) (Kidney international, 2017-02)

Acute kidney injury is a devastating disease with high morbidity in hospitalized patients and contributes to the pathogenesis of chronic kidney disease. An underlying mechanism of acute kidney injury involves ischemia-reperfusion ...

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma.

Agboola, KM; Bradrick, Shelton S; Choi, SS; Diehl, Anna Mae; Fernandez-Zapico, ME; Jhaveri, R; Jung, Y; ... (16 authors) (Lab Invest, 2010-12)

Hedgehog (Hh) pathway activation promotes many processes that occur during fibrogenic liver repair. Whether the Hh pathway modulates the outcomes of virally mediated liver injury has never been examined. Gene-profiling studies ...