Browsing by Subject "Genetics"
Now showing items 21-40 of 276
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Chemical and Genetic Modulation of the Host Immune Response to Mycobacterial Infection
(2018)Mycobacterium tuberculosis (Mtb) is the causative agent of the disease tuberculosis, which kills more people worldwide than any other infectious disease. In 2017, nearly 2 million people died of tuberculosis. Despite the ... -
Chromatin Dynamics and Regulation of the Helicase During Replication Initiation
(2021)DNA replication is an intricate process within eukaryotic cells that must be precisely executed to preserve genetic information. This process begins at multiple start sites, or origins of replication, along each chromosome ... -
Chromatin-based Reprogramming of Courtship Regulators With Social Experience
(2021)Organisms are presented with a wide variety of environmental stimuli and must interpret and respond to these cues in to perform a wide variety of behaviors, such as foraging, mating, fleeing, and fighting. The ability of ... -
Codon Usage Biases Differ Between Tissues and Can Confer Tissue-Specific Gene Expression in Drosophila
(2022)Codon usage bias is a fundamental aspect of the genetic code. For many years synonymous mutations to a coding sequence were considered to be functionally “silent.” We now appreciate that is not the case and that synonymous ... -
Comparing Properties of Oscillating Gene Networks in Diverged Species
(2022)Multiple biological processes occur in a time-dependent fashion. One of the most prevalent ways of regulating rhythmic biology is by controlling the timing and dosage of gene expression. Gene regulatory networks are groups ... -
Competing RNA Structures and Their Effects on HDV Antigenomic RNA Self-cleavage and mRNA Processing
(2010)HDV antigenomic RNA is processed in two distinct pathways; it can be cleaved at the polyA site and polyadenylated to become mRNA for the delta antigens, or the RNA can be cleaved by the antigenomic ribozyme to become full-length ... -
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
(The Journal of clinical investigation, 2019-01)Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting ... -
Concentration-dependent recruitment of mammalian odorant receptors
(2019)Deciphering natural odor plumes with dynamic changes in odor concentrations presents a common challenge to all animals. A fundamental challenge in studying the organization principles of the olfactory system to encode odor ... -
Consequences of Extended Early-Life Starvation in Adult Caenorhabditis elegans
(2021)The roundworm C. elegans reversibly arrests larval development during starvation, but extended early-life starvation reduces reproductive success. Maternal dietary restriction (DR) buffers progeny from starvation as young ... -
Convergence of Genetic Disease Association and Ocular Expression
(2012)The visual system in humans provides the ability to interpret our surroundings from many distances. This complex system serves as a powerful sense which can drastically impact the quality of life when threatened or eliminated. ... -
Cryptococcus neoformans transcriptional regulation of the host-pathogen interface
(2013)<italic>Cryptococcus neoformans </italic>is a human fungal pathogen that is also ubiquitous in the environment. To cause disease inside a human host, <italic>C. neoformans</italic> must be able to sense and respond to a ... -
Cytoplasmic N6-Methyladenosine Deposition on Hepatitis C Viral RNA
(2022)Hepatitis C virus (HCV) exploits nearly all aspects of cellular RNA biology to regulate its viral RNA genome during infection. However, the molecular mechanisms by which HCV exploits one aspect of RNA regulation, RNA modification ... -
Defining Determinants of Primary Drug Resistance in Precision Cancer Therapies
(2021)The dramatic expansion of genomic sequencing methodologies, applications and efforts has empowered our abilities to deepen the conceptual understanding of complex biological processes, including diseases like cancer. Through ... -
Degenerin/Epithelial Sodium Channels (DEG/ENaCs) Required for Mechanical Nociception Responses in <italic>Drosophila melanogaster</italic>
(2014)<italic>Drosophila</italic> larvae respond to potentially tissue-damaging stimuli with nocifensive escape locomotion (NEL). NEL is a stereotyped withdrawal behavior in which the larva rotates along its long-body axis in ... -
Dengue Virus Host Factors
(2009)Dengue fever and dengue hemorrhagic fever are estimated to afflict 50-100 million people annually and are caused by one of the four serotypes of dengue virus. Dengue virus is carried and transmitted to humans by mosquitoes ... -
Determining the Role of DDX3X in Normal and Malignant Germinal Center B Cells
(2019)Burkitt lymphoma (BL) is an aggressive germinal center (GC) B cell derived lymphoma. BL accounts for 40% of pediatric lymphoma cases in the United States and over half of all pediatric malignancies in Sub Saharan Africa. ... -
Developing Molecular Tools for Interrogating a Vocal Learning Avian Species
(2020)The zebra finch, an Australian songbird, is a uniquely powerful model organism for the study of vocal production learning, and its song system shares behavioral, anatomical, and genetic properties with the human spoken language ... -
Development and Application of Novel CRISPR-Based Epigenome Editors
(2020)The eukaryotic epigenome has an instrumental role in determining and maintaining cell identity and function. Epigenetic components such as DNA methylation, histone tail modifications, chromatin accessibility, and DNA architecture ... -
Development of a High-Throughput Human iPSC Chondrogenesis Platform and Applications for Arthritis Disease Modeling
(2019)The differentiation of human induced pluripotent stem cells (hiPSCs) to prescribed cell fates enables the engineering of patient-specific tissue types, such as hyaline cartilage, for applications in regenerative medicine, ... -
Developmental Regulation in Response to Nutritional Status in Caenorhabditis elegans
(2019)Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode C. elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. Despite the essential role ...
