Browsing by Subject "Randomized Controlled Trials as Topic"
Now showing items 21-40 of 57
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Intravenous starches: is suspension the best solution?
(Anesth Analg, 2014-09) -
Meta-analysis of Placebo-Controlled Randomized Controlled Trials on the Prevalence of Statin Intolerance.
(Am J Cardiol, 2017-09-01)The prevalence of intolerance varies widely. Stopping statin therapy is associated with worse outcomes in patients with cardiovascular disease. Despite extensive studies, the benefits and risks of statins continue to be ... -
Missing data in randomized clinical trials for weight loss: scope of the problem, state of the field, and performance of statistical methods.
(PLoS One, 2009-08-13)BACKGROUND: Dropouts and missing data are nearly-ubiquitous in obesity randomized controlled trails, threatening validity and generalizability of conclusions. Herein, we meta-analytically evaluate the extent of missing data, ... -
Model validity and risk of bias in randomised placebo-controlled trials of individualised homeopathic treatment.
(Complement Ther Med, 2016-04)BACKGROUND: To date, our programme of systematic reviews has assessed randomised controlled trials (RCTs) of individualised homeopathy separately for risk of bias (RoB) and for model validity of homeopathic treatment (MVHT). ... -
Models for Predicting Recurrence, Complications, and Health Status in Women After Pelvic Organ Prolapse Surgery.
(Obstetrics and gynecology, 2018-08)OBJECTIVE:To develop statistical models predicting recurrent pelvic organ prolapse, surgical complications, and change in health status 12 months after apical prolapse surgery. METHODS:Logistic regression models were developed ... -
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.
(Nature communications, 2021-04-15)Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate ... -
Neurosurgical Randomized Trials in Low- and Middle-Income Countries.
(Neurosurgery, 2020-09)<h4>Background</h4>The setting of a randomized trial can determine whether its findings are generalizable and can therefore apply to different settings. The contribution of low- and middle-income countries (LMICs) ... -
Off-label closure during CLOSURE study.
(J Invasive Cardiol, 2012-11)BACKGROUND: The role of percutaneous closure of patent foramen ovale (PFO) in patients with cryptogenic stroke or transient ischemic attack remains controversial. Registry data have suggested considerable benefit of closure ... -
Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis.
(Br J Cancer, 2008-01-29)The aim of this study was to determine the efficacy of palliative oxygen for relief of dyspnoea in cancer patients. MEDLINE and EMBASE were searched for randomised controlled trials, comparing oxygen and medical air in cancer ... -
Paravertebral Block for Inguinal Herniorrhaphy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
(Anesth Analg, 2015-08)BACKGROUND: Paravertebral block (PVB) is a safe and effective anesthetic technique for thoracotomy and mastectomy. However, no systematic review or meta-analysis has focused on PVB for inguinal herniorrhaphy. Our study compares ... -
Patient Factors That Influence Decision Making: Randomization Versus Observational Nonoperative Versus Observational Operative Treatment for Adult Symptomatic Lumbar Scoliosis.
(Spine, 2016-03)<h4>Study design</h4>A prospective study with randomized and observational cohorts.<h4>Objective</h4>The aim of this study was to determine baseline variables affecting adult symptomatic lumbar scoliosis (ASLS) decision ... -
Perioperative fluid and hemodynamic management within an enhanced recovery pathway.
(Journal of surgical oncology, 2017-10)Goal-directed fluid therapy (GDFT) seeks to improve outcomes through individualized optimization of oxygen delivery using IV fluid and vasoactive infusions. Trials of GDFT show clinical benefits over traditional liberal ... -
Power and sample size calculations for the Wilcoxon-Mann-Whitney test in the presence of death-censored observations.
(Stat Med, 2015-02-10)We consider a clinical trial of a potentially lethal disease in which patients are randomly assigned to two treatment groups and are followed for a fixed period of time; a continuous endpoint is measured at the end of follow-up. ... -
Pragmatic multicentre stepped-wedge cluster randomised trial to investigate the effectiveness of community-based falls prevention programme for older adults with falls risk in Singapore: a protocol paper.
(BMJ open, 2023-06)<h4>Introduction</h4>Falls are an important public health issue with consequences that include injuries, quality of life reduction and high healthcare costs. Studies show that falls prevention strategies are effective in ... -
Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial.
(BMJ open, 2022-06)<h4>Introduction</h4>Infertility is a common complication of endometriosis. While in vitro fertilisation-embryo transfer (IVF) successfully treats endometriosis-associated infertility, there is some evidence that pregnancy ... -
Predicting Risk of Urinary Incontinence and Adverse Events After Midurethral Sling Surgery in Women.
(Obstet Gynecol, 2016-02)OBJECTIVE: To construct and validate models that predict a patient's risk of developing stress and urgency urinary incontinence and adverse events 12 months after sling surgery. METHODS: This was a secondary analysis of ... -
Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism.
(PLoS One, 2012)Previous observational studies have reported associations between prostate cancer and alpha-linolenic acid (ALA). However, few investigations have been able to study this relationship prospectively and in well-controlled ... -
Provider-supported self-management cognitive behavioral therapy for insomnia (Tele-Self CBTi): Protocol for a randomized controlled trial.
(Contemporary clinical trials, 2023-02)<h4>Background</h4>Cognitive Behavioral Therapy for Insomnia (CBTi) is recommended as first-line treatment for insomnia, yet patient access to CBTi is limited. Self-help CBTi could increase patient access. Self-help CBTI ... -
Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis.
(Systematic reviews, 2014-12)<h4>Background</h4>A rigorous and focused systematic review and meta-analysis of randomised controlled trials (RCTs) of individualised homeopathic treatment has not previously been undertaken. We tested the hypothesis that ... -
Randomised, double-blind, placebo-controlled trial of Probiotics To Eliminate COVID-19 Transmission in Exposed Household Contacts (PROTECT-EHC): a clinical trial protocol.
(BMJ open, 2021-05-05)<h4>Introduction</h4>The COVID-19 pandemic has proven to be an unprecedented challenge to worldwide health, and strategies to mitigate the spread and severity of COVID-19 infection are urgently needed. Emerging evidence ...
