Browsing by Subject "Rats, Sprague-Dawley"
Now showing items 21-40 of 48
-
Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome.
(Advanced healthcare materials, 2019-07)Stem cell therapies have made strides toward the efficacious treatment of injured endometrium and the prevention of intrauterine adhesions, or Asherman's syndrome (AS). Despite this progress, they are limited by their risk ... -
Impact of acute nicotine exposure on monoaminergic systems in adolescent and adult male and female rats.
(Neurotoxicology and teratology, 2022-09)Adolescence is a period of risk for beginning tobacco addiction. Differential neural response to nicotine in adolescents vs. adults may help explain the increased vulnerability to nicotine self-administration seen with adolescent ... -
Increased renal dopamine and acute renal adaptation to a high-phosphate diet.
(American journal of physiology. Renal physiology, 2011-05)The current experiments explore the role of dopamine in facilitating the acute increase in renal phosphate excretion in response to a high-phosphate diet. Compared with a low-phosphate (0.1%) diet for 24 h, mice ... -
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
(J Clin Invest, 2010-03)The autosomal recessive kidney disease nephronophthisis (NPHP) constitutes the most frequent genetic cause of terminal renal failure in the first 3 decades of life. Ten causative genes (NPHP1-NPHP9 and NPHP11), whose products ... -
Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep.
(J Neurosci, 2002-12-15)Rapid-eye-movement (REM) sleep plays a key role in the consolidation of memories acquired during waking (WK). The search for mechanisms underlying that role has revealed significant correlations in the patterns of neuronal ... -
Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration.
(Biomaterials, 2013-10)Cell delivery to the pathological intervertebral disc (IVD) has significant therapeutic potential for enhancing IVD regeneration. The development of injectable biomaterials that retain delivered cells, promote cell survival, ... -
Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance.
(J Biomed Mater Res A, 2010-06-15)An optical window model for the rodent dorsum was used to perform chronic and quantitative intravital microscopy and laser Doppler flowmetry of microvascular networks adjacent to functional and non-functional glucose sensors. ... -
Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism.
(Arthritis research & therapy, 2011-08-26)Tumor necrosis factor-α (TNFα) has received significant attention as a mediator of lumbar radiculopathy, with interest in TNF antagonism to treat radiculopathy. Prior studies have demonstrated that TNF antagonists can attenuate ... -
Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: radial-arm maze performance and operant food reinforced responding.
(PloS one, 2013-01)<h4>Background</h4>Adolescence is not only a critical period of late-stage neurological development in humans, but is also a period in which ethanol consumption is often at its highest. Given the prevalence of ethanol use ... -
Magnetic resonance water proton relaxation in protein solutions and tissue: T(1rho) dispersion characterization.
(PLoS One, 2010-01-05)BACKGROUND: Image contrast in clinical MRI is often determined by differences in tissue water proton relaxation behavior. However, many aspects of water proton relaxation in complex biological media, such as protein solutions ... -
Measuring attention in rats with a visual signal detection task: Signal intensity vs. signal duration.
(Pharmacology, biochemistry, and behavior, 2020-12)Measurement of attentional performance in animal behavioral research allows us to investigate neural mechanisms underlying attentional processes and translate results to better understand human attentional function, dysfunction ... -
Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina.
(PLoS biology, 2019-04)The stream of visual information sent from photoreceptors to second-order bipolar cells is intercepted by laterally interacting horizontal cells that generate feedback to optimize and improve the efficiency of signal ... -
Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.
(Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017-10)Early-life conditions can contribute to the propensity for developing neuropsychiatric disease, including substance abuse disorders. However, the long-lasting mechanisms that shape risk or resilience for drug addiction remain ... -
Paternal cannabis extract exposure in rats: Preconception timing effects on neurodevelopmental behavior in offspring.
(Neurotoxicology, 2020-12)Maternal toxicant exposure during gestation can have deleterious effects on neurobehavioral development of the offspring. The potential risks engendered by paternal toxicant exposure prior to conception have been largely ... -
Paternal factors in neurodevelopmental toxicology: THC exposure of male rats causes long-lasting neurobehavioral effects in their offspring.
(Neurotoxicology, 2020-05)The potential health risks of cannabis are of growing concern, including effects on reproduction and development. Extensive research has investigated risks associated with maternal exposure to THC during gestation and its ... -
Paternal Δ9-Tetrahydrocannabinol Exposure Prior to Mating Elicits Deficits in Cholinergic Synaptic Function in the Offspring.
(Toxicological sciences : an official journal of the Society of Toxicology, 2020-04)Little attention has been paid to the potential impact of paternal marijuana use on offspring brain development. We administered Δ9-tetrahydrocannabinol (THC, 0, 2, or 4 mg/kg/day) to male rats for 28 days. Two days after ... -
Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor.
(Environmental health perspectives, 2005-08)Exposure to particulate matter (PM) is associated with acute cardiovascular mortality and morbidity, but the mechanisms are not entirely clear. In this study, we hypothesized that PM may activate the angiotensin type 1 receptor ... -
Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection.
(PLoS One, 2015)Although neuroanatomical tracing studies have defined the origin and targets of major projection neurons (PN) of the central nervous system (CNS), there is much less information about the circuits that influence these neurons. ... -
Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats.
(Am J Physiol Endocrinol Metab, 2016-03-15)Biomarkers of muscle protein synthesis rate could provide early data demonstrating anabolic efficacy for treating muscle-wasting conditions. Androgenic therapies have been shown to increase muscle mass primarily by increasing ... -
Self-administration by female rats of low doses of nicotine alone vs. nicotine in tobacco smoke extract.
(Drug and alcohol dependence, 2021-11)<h4>Background</h4>Nicotine has reinforcing effects, but there are thousands of other compounds in tobacco, some of which might interact with nicotine reinforcement.<h4>Aims</h4>This rat study was conducted to determine ...
