Browsing by Subject "aging"
Now showing items 21-37 of 37
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Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival.
(Front Public Health, 2014)Longitudinal data on aging, health, and longevity provide a wealth of information to investigate different aspects of the processes of aging and development of diseases leading to death. Statistical methods aimed at analyses ... -
L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development.
(Worm, 2016-04)Post-embryonic development is governed by nutrient availability. L1 arrest, dauer formation and aging illustrate how starvation, anticipation of starvation and caloric restriction have profound influence on C. elegans ... -
Later-life effects of early-life benzo(a)pyrene and triphenyl phosphate exposure on respiration in zebrafish (Danio rerio)
(2021-04-30)Benzo(a)pyrene (BAP) is a polycyclic aromatic hydrocarbon with carcinogenic metabolites. Triphenyl phosphate (TPP) is an organophosphate ester often used as a flame retardant and plasticizer. This study assessed exposures ... -
Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice.
(Aging and disease, 2018-02)Experimental cardiac arrest (CA) in aging research is infrequently studied in part due to the limitation of animal models. We aimed to develop an easily performed mouse CA model to meet this need. A standard mouse KCl-induced ... -
Oxidative Stress and Thrombosis during Aging: The Roles of Oxidative Stress in RBCs in Venous Thrombosis.
(International journal of molecular sciences, 2020-06-15)Mid-life stage adults are at higher risk of developing venous thrombosis (VT)/thromboembolism (VT/E). Aging is characterized by an overproduction of reactive oxygen species (ROS), which could evoke a series of physiological ... -
Physical and mental decline and yet rather happy? A study of Danes aged 45 and older.
(Aging Ment Health, 2015)OBJECTIVES: Little is known about whether the feeling of happiness follows the age-related decline in physical and mental functioning. The objective of this study was to analyze differences with age in physical and mental ... -
Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool.
(Journal of general internal medicine, 2021-01)<h4>Background</h4>As populations age with increasingly complex chronic conditions, segmenting populations into clinically meaningful categories of healthcare and related service needs can provide healthcare planners with ... -
Quantification of biological aging in young adults.
(Proc Natl Acad Sci U S A, 2015-07-28)Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young ... -
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm.
(eLife, 2020-05-05)Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints ... -
Self-Regulation before and after a Developmental Transition: a Study of Adaptive Goal Change in Retirement
(2008-08-08)Retirement is the quintessential transition from mid-life to late-life for many working Americans. However, questions about the positive and negative effects of retirement have sparked widely divergent empirical findings. ... -
Sexual risk behaviors and HIV risk among Americans aged 50 years or older: a review.
(Subst Abuse Rehabil, 2015)Although HIV-related sexual risk behaviors have been studied extensively in adolescents and young adults, there is limited information about these behaviors among older Americans, which make up a growing segment of the US ... -
Site-Specific Effects of Online rTMS during a Working Memory Task in Healthy Older Adults.
(Brain sciences, 2020-04-27)The process of manipulating information within working memory is central to many cognitive functions, but also declines rapidly in old age. Improving this process could markedly enhance the health-span in older adults. The ... -
The Age of Obsolescence: Senescence and Scientific Rejuvenation in Twentieth Century America
(2008-12-11)Growing "old" in contemporary American society often means being seen as a problem: you threaten the stability of Social Security and Medicare; cutting-edge science seeks a cure for what ages you; cosmetic companies and ... -
The effects of aging on the BTBR mouse model of autism spectrum disorder.
(Front Aging Neurosci, 2014)Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by alterations in social functioning, communicative abilities, and engagement in repetitive or restrictive behaviors. The ... -
The Regulation of AMD Pathobiology by Complement Factor H
(2016)Complement factor H (CFH) is a major susceptibility gene for age-related macular degeneration (AMD); however, its impact on AMD pathobiology is unresolved. Here, the role of CFH in the development of AMD pathology in vivo ... -
Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.
(Aging Cell, 2017-02)Traditionally, genomewide association studies (GWAS) have emphasized the benefits of large samples in the analyses of age-related traits rather than their specific properties. We adopted a realistic concept of genetic ... -
Understanding the Self-compassionate Mindset in Older Adults
(2011)Self-compassion has been shown to predict well-being, possibly by buffering people against the unpleasant emotional and cognitive reactions that accompany negative life events. Although most previous research has been conducted ...
