Browsing by Subject "Oncology"
Now showing items 41-60 of 102
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Identification of Mechanisms and Pathways Involved in MLL2-Mediated Tumorigenesis
(2013)Myeloid/lymphoid or mixed-lineage leukemia (MLL)-family genes encode histone lysine methyltransferases that play important roles in epigenetic regulation of gene transcription, and these genes are frequently mutated in human ... -
Identifying Critical Biological Effectors in Glioma Initiating Cells
(2012)Glioblastoma (GBM) represents the most common and lethal brain tumor in adults, with glioma initiating cells (GICs) implicated to play a critical role in its progression and recurrence. However, the molecular mechanisms ... -
Immunologic Targeting and Biologic Underpinnings of Human Cytomegalovirus in Glioblastoma
(2015)Glioblastoma (GBM) is a grade IV astrocytoma in which the median overall survival is approximately 15 months at time of diagnosis. Even with the current multi- modal therapeutic approach of surgery, chemotherapy with the ... -
Inflammation-Dependent Regulation of Hepatocellular Carcinoma Tumor Progression
(2015)Liver cancer is a devastating disease that is the 5th most common cancer in men, 7th most common cancer in women, and the 3rd leading cause of cancer-related mortality. This disease arises from multiple etiological factors, ... -
Integrative Computational Genomics Defines the Molecular Origins and Outcomes of Lymphoma
(2016)Lymphomas are a heterogeneous group of hematological malignancies composed of diseases with diverse molecular origins and clinical outcomes. Derived from immune cells of lymphoid origin, lymphoma can arise from lymphoid ... -
Inter-Instituion Application of Knowledge-Based IMRT Treatment Planning
(2012)Intensity Modulated Radiation Therapy (IMRT) has allowed a large degree of healthy tissue sparing while delivering therapeutic dose to tumors. However, the treatment planning process for IMRT is iterative and time consuming ... -
Investigating Cognitive/Affective/Sleep disturbance symptoms in Patients Receiving High-Dose Interleukin-2 Therapy
(2018)Patients undergoing intensive treatments for life-limiting chronic illnesses such as cancer often experience severe cognitive, affective, and sleep disturbance symptoms. Immunotherapies such as high-dose Interleukin-2 (IL-2) ... -
Investigation of High Resolution 3D Rodent-morphic Dosimetry, and Cost-Effective Optical-CT using Fresnel Lenses
(2014)Micro-irradiators enable exploration of the efficacy of novel radiation treatment approaches by providing the capability to reproduce realistic treatment delivery in small animal models. An approach of current topical interest ... -
Investigation of Patient Positioning Accuracy in Lung Stereotactic Body Radiation Therapy
(2013)Purpose: It has been shown that patients' irregular breathing can cause variation in the delineation of the internal target volume (ITV) and affect the accuracy of four dimensional computed tomography (4DCT) and cone-beam ... -
Investigation of Presage 3D Dosimetry as a Method of Clinically Intuitive Quality Assurance and Comparison to a Semi-3D Delta4 System
(2015)The need for clinically intuitive metrics for patient-specific quality assurance in radiation therapy has been well-documented (Zhen, Nelms et al. 2011). A novel transform method has shown to be effective at converting ... -
Knowledge Based Radiation Therapy with Three Dimensional Registration of the Planning Target Volume
(2012)Knowledge based radiation therapy planning was developed as a way to use a knowledge base of clinically approved radiation therapy plans to shorten the amount of time necessary to create a new treatment plan. The method ... -
Knowledge Modeling for The Outcome of Brain Stereotactic Radiosurgery
(2016)Purpose: To build a model that will predict the survival time for patients that were treated with stereotactic radiosurgery for brain metastases using support vector machine (SVM) regression. Methods and Materials: This ... -
Lactate Metabolism in Cancer Cell Lines
(2013)Pathophysiologic lactate accumulation is characteristic of solid tumors and has been associated with metastases and poor overall survival in cancer patients. In recent years, there has been a resurgence of interest in tumor ... -
Leveraging the Requirement of MEK1/2 Kinases for Copper to Inhibit the MAPK Pathway in Oncogenic BRAF-Driven Cancer
(2016)The gene BRAF is mutated to remain aberrantly activated in a large number of human malignancies, most prominently in melanoma. The most common mutation in BRAF is a missense mutation that substitutes glutamic acid for valine ... -
Mechanism of Cyclin D1 regulation by progestins in breast cancer
(2014)The majority of breast tumors express the estrogen receptor (ER), and more than half of these cancers also express the progesterone receptor (PR). While the actions of ER on breast cancer pathogenesis are well understood, ... -
Membrane GRP78: Pathologic and Therapeutic Roles in Ovarian Cancer
(2014)Ovarian cancer is the fifth leading cause of cancer-related death in the United States and the most lethal gynecologic malignancy. Patients with ovarian cancer are generally diagnosed at stage III or IV, when ascites fluid ... -
Metaboloptics: In Vivo Optical Imaging to Enable Simultaneous Measurement of Glucose Uptake, Mitochondrial Membrane Potential, and Vascular Features in Cancer
(2016)Altered metabolism is a hallmark of almost all cancers. A tumor’s metabolic phenotype can drastically change its ability to proliferate and to survive stressors such as hypoxia or therapy. Metabolism can be used as a diagnostic ... -
Molecular Characterization of Genetic and Epigenetic Alterations in Gliomas
(2012)Glioma development and progression are driven by complex genetic alterations, including point mutations and gain or loss of genomic copy number, as well as epigenetic aberrations, including DNA methylation and histone ... -
Molecular Mechanisms Governing the Untoward Tumor Growth Promoting Effects of Selective Estrogen Receptor Modulators
(2018)Luminal breast cancer is among the most prevalent diseases in women in the United States and worldwide. Historically, luminal cancers have been effectively managed with treatments that alter the availability of estrogens ... -
Monte Carlo Analysis and Physics Characterization of a Novel Nanoparticle Detector for Medical and Micro-dosimetry Applications
(2015)The outcomes for both (i) radiation therapy and (ii) preclinical small animal radio- biology studies are dependent on the delivery of a known quantity of radiation to a specific and intentional location. Adverse effects can ...
