Browsing by Title
Now showing items 11061-11080 of 20534
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M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer.
(PLoS One, 2012)OBJECTIVE: In this study, we explored the use of mechanical high intensity focused ultrasound (M-HIFU) as a neo-adjuvant therapy prior to surgical resection of the primary tumor. We also investigated the role of signal transducer ... -
Machiavelli's Moral Theory: Moral Christianity versus Civic Virtue
(2017-01-11)Nicolas Machiavelli is deemed to be the representative par excellence of the lack of morality and ethics in politics. The theory that “the end justifies the means” encapsulates his political and moral thought. The adjective ... -
Machine Learning and Security Studies
(2020)I present three papers that demonstrate how the cultural and technological advances in the machine learning literature can and should impact quantitative security studies. Although the math behind many machine learning techniques ... -
Machine Learning Applications for Objectively Assessing Surgical Skill and Instrument Dynamics
(2019)The goals set forth in this dissertation are centered on advancing the current state-of-the-art literature for applying analytical approaches to determining surgical proficiency, testing new metrics for surgical movement ... -
Machine Learning to Predict Developmental Neurotoxicity with High-throughput Data from 2D Bio-engineered Tissues
There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary ... -
Machine Learning with Dirichlet and Beta Process Priors: Theory and Applications
(2010)Bayesian nonparametric methods are useful for modeling data without having to define the complexity of the entire model <italic>a priori</italic>, but rather allowing for this complexity to be determined by the data. Two ... -
Machine Learning, Phase Stability, and Disorder with the Automatic Flow Framework for Materials Discovery
(2018)Traditional materials discovery approaches - relying primarily on laborious experiments - have controlled the pace of technology. Instead, computational approaches offer an accelerated path: high-throughput exploration and ... -
Machine Learning-based Techniques to Address Spectral Distortions in Photon Counting X-ray Computed Tomography
(2016)Spectral CT using a photon counting x-ray detector (PCXD) shows great potential for measuring material composition based on energy dependent x-ray attenuation. Spectral CT is especially suited for imaging with K-edge contrast ... -
Machine Poetics: Pound, Stein and the Modernist Imagination
(2011)This dissertation intervenes in the fields of modernist criticism and new media studies to examine an under-appreciated reciprocity between them. I argue that this reciprocity has not yet been adequately incorporated into ... -
Macitentan (Opsumit) for the treatment of pulmonary arterial hypertension
(Expert Review of Clinical Pharmacology, 2014-07) -
Macro to Micro Legacies of Landuse at the Calhoun Critical Zone Observatory
(2018)In this dissertation, human-critical zone (CZ) dynamics are explored at the Calhoun Critical Zone Observatory (CCZO). The 190km2 CCZO is part of a broader landscape in the southeastern US which was subjected to extensive ... -
Macro-Comparative Political Analysis: Do Different Healthcare Systems Result in Differential National Health Outcomes?
(2019-03-26)In this study, I will conduct a comparative analysis of how the the political-economic set-up of health care systems in affluent capitalist democracies may affect aggregate health care performance in designated OECD nations ... -
Macroalgae Farming: A Strategy for Economic Growth and Nutrient Mitigation
(2015-04-24)Macroalgae Farming: A Strategy for Economic Growth and Nutrient Mitigation Executive Summary Alyson Myers April 2015 Email: alysonmyers1@gmail.com The estuarine system of the Chesapeake Bay has experienced a “tragedy ... -
Macroevolution of Primate Skull Shape: Combining Geometric Morphometrics and Phylogenetic Comparative Methods
(2018)Primates span incredible behavioral and ecological diversity, and this diversity is reflected in the shape of the skull. This dissertation asks two questions surrounding the evolution of primate skull shape: 1) what are ... -
Macroinvertebrate Habitat Availability and Utilization on the Eno River
(2008-04-25)Increasing competition between offstream and instream water uses emphasizes the need for accurate and equitable river management decisions. Minimum instream flow requirements necessary to sustain aquatic diversity can best ... -
Macromolecular Organization of the Rough Endoplasmic Reticulum at Homeostasis and Stress
(2019)The endoplasmic reticulum (ER) is an organelle that exists as a patchwork offunctional membrane domains with unique protein components. The rough ER is onesuch domain characterized by associated ribosomal particles and is ... -
Macrophage Activation in Dormant and Recurrent Breast Tumors
(2017-05-12)Over 240,000 new breast cancer cases were estimated to be diagnosed cases in 2016. Beyond this, an estimated 40,000 deaths were due to breast cancer last year. Of these deaths, over half are due to recurrence of the disease ... -
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.
(Nature communications, 2018-12-05)The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are unknown. Here we report that young macrophage cells ... -
Macroprudential Policies and Financial Frictions
(2017)This dissertation consists of two essays on macropudential policies and financial frictions. In the first essay, the Reserve Option Mechanism, an unconventional policy tool invented and used by the Central Bank of the Republic ...
