Browsing by Affiliation of Duke Author(s) "Biomedical Engineering"
Now showing items 1-20 of 466
-
3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea.
(Opt Express, 2010-04-26)Capable of three-dimensional imaging of the cornea with micrometer-scale resolution, spectral domain-optical coherence tomography (SDOCT) offers potential advantages over Placido ring and Scheimpflug photography based systems ... -
A Binaural Cochlear Implant Sound Coding Strategy Inspired by the Contralateral Medial Olivocochlear Reflex.
(Ear Hear, 2016-05)OBJECTIVES: In natural hearing, cochlear mechanical compression is dynamically adjusted via the efferent medial olivocochlear reflex (MOCR). These adjustments probably help understanding speech in noisy environments and ... -
A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer.
(PloS one, 2018-01)Computed tomography (CT) is the standard imaging test used for the screening and assessment of suspected lung cancer, but distinguishing malignant from benign nodules by CT is an ongoing challenge. Consequently, a large ... -
A corollary discharge for perceptual stability
(PERCEPTION, 2006) -
A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays.
(Biomedical optics express, 2012-12)Diffuse reflectance spectroscopy (DRS) is a well-established method to quantitatively distinguish between benign and cancerous tissue for tumor margin assessment. Current multipixel DRS margin assessment tools are bulky ... -
A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation.
(J Control Release, 2013-10-10)Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic ... -
A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
(Open Forum Infect Dis, 2016-01)Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores ... -
A highly sensitive Raman method for selective cyanide detection based on evaporated cuprous iodide substrate
(Analytical Methods, 2010-05-01)A strong interaction between cyanide anion and copper(i) cation in combination with non-resonant Raman fingerprinting allows the selective sensing of aqueous free cynanide with high sensitivity to parts per billion (ppb)-level. ... -
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
(PLoS One, 2013)There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional ... -
A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division.
(Elife, 2016-04-14)The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity. Here ... -
A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.
(Opt Express, 2010-06-07)The ability of diffuse reflectance spectroscopy to extract quantitative biological composition of tissues has been used to discern tissue types in both pre-clinical and clinical cancer studies. Typically, diffuse reflectance ... -
A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.
(Cell Stem Cell, 2016-02-04)Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein cell fate determinants coordinate with each other remains unclear. Here, we show that miR-34a directly suppresses ... -
A model of variability in brain stimulation evoked responses.
(Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2012)The input-output (IO) curve of cortical neuron populations is a key measure of neural excitability and is related to other response measures including the motor threshold which is widely used for individualization ... -
A Modular Multilevel Series/Parallel Converter for a Wide Frequency Range Operation
(IEEE Transactions on Power Electronics, 2019-10-01)When providing ac output, modular multilevel converters (MMCs) experience power fluctuation in the phase arms. The power fluctuation causes voltage ripple on the module capacitors, which grows with the output power and inversely ... -
A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels.
(Nature, 2008-02-14)Ca2+/calmodulin-dependent regulation of voltage-gated CaV1-2 Ca2+ channels shows extraordinary modes of spatial Ca2+ decoding and channel modulation, vital for many biological functions. A single calmodulin (CaM) molecule ... -
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
(Sci Signal, 2013-05-07)In the intrinsic pathway of apoptosis, cell-damaging signals promote the release of cytochrome c from mitochondria, triggering activation of the Apaf-1 and caspase-9 apoptosome. The ubiquitin E3 ligase MDM2 decreases the ... -
A noisy linear map underlies oscillations in cell size and gene expression in bacteria.
(Nature, 2015-07-16)During bacterial growth, a cell approximately doubles in size before division, after which it splits into two daughter cells. This process is subjected to the inherent perturbations of cellular noise and thus requires regulation ... -
A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
(Arthritis Res Ther, 2016-04-12)BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our objective was to explore the relationships of GlycA, a measure of glycosylated acute phase proteins, with inflammation and cardiometabolic ... -
A pathway in primate brain for internal monitoring of movements.
(Science, 2002-05-24)It is essential to keep track of the movements we make, and one way to do that is to monitor correlates, or corollary discharges, of neuronal movement commands. We hypothesized that a previously identified pathway from brainstem ... -
A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium
<jats:p>Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models that can closely recapitulate human physiological responses. ...
