Browsing by Affiliation of Duke Author(s) "Biostatistics & Bioinformatics"
Now showing items 1-20 of 585
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10 Years with ICH E10: Choice of Control Groups.
(Pharm Stat, 2011-09) -
A Bayesian approach for individual-level drug benefit-risk assessment.
(Statistics in medicine, 2019-07)In existing benefit-risk assessment (BRA) methods, benefit and risk criteria are usually identified and defined separately based on aggregated clinical data and therefore ignore the individual-level differences as well as ... -
A Bayesian Approach to Graphical Record Linkage and Deduplication
(Journal of the American Statistical Association, 2016-10-01)© 2016 American Statistical Association.We propose an unsupervised approach for linking records across arbitrarily many files, while simultaneously detecting duplicate records within files. Our key innovation involves the ... -
A Bayesian approach to joint analysis of multivariate longitudinal data and parametric accelerated failure time
(Statistics in Medicine, 2014) -
A Bayesian model for misclassified binary outcomes and correlated survival data with applications to breast cancer
(Statistics in Medicine, 2013) -
A cluster randomized controlled trial of a behavioral intervention to facilitate the development and implementation of clinical practice guidelines in Latin American maternity hospitals: the Guidelines Trial: Study protocol [ISRCTN82417627].
(BMC women's health, 2005-04-11)BACKGROUND: A significant proportion of the health care administered to women in Latin American maternity hospitals during labor and delivery has been demonstrated to be ineffective or harmful, whereas effective interventions ... -
A comparison of host response strategies to distinguish bacterial and viral infection.
(PloS one, 2021-01)<h4>Objectives</h4>Compare three host response strategies to distinguish bacterial and viral etiologies of acute respiratory illness (ARI).<h4>Methods</h4>In this observational cohort study, procalcitonin, a 3-protein panel ... -
A comprehensive infrastructure for big data in cancer research: Accelerating cancer research and precision medicine
(Frontiers in Cell and Developmental Biology, 2017-09-21)© 2017 Hinkson, Davidsen, Klemm, Kerlavage and Kibbe. Advancements in next-generation sequencing and other -omics technologies are accelerating the detailed molecular characterization of individual patient tumors, and driving ... -
A conjoined universal helper epitope can unveil antitumor effects of a neoantigen vaccine targeting an MHC class I-restricted neoepitope.
(NPJ vaccines, 2021-01-18)Personalized cancer vaccines targeting neoantigens arising from somatic missense mutations are currently being evaluated for the treatment of various cancers due to their potential to elicit a multivalent, tumor-specific ... -
A cord blood monocyte-derived cell therapy product accelerates brain remyelination.
(JCI insight, 2016-08-18)Microglia and monocytes play important roles in regulating brain remyelination. We developed DUOC-01, a cell therapy product intended for treatment of demyelinating diseases, from banked human umbilical cord blood ... -
A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.
(Nature communications, 2018-10-24)The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine ... -
A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.
(BMC Bioinformatics, 2013-12-16)BACKGROUND: The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, ... -
A Framework for Safety Evaluation Throughout the Product Development Life-Cycle
(Therapeutic Innovation and Regulatory Science, 2019-01-01)© 2019, The Drug Information Association, Inc. Evaluation of the safety profile of medicines is moving from a more reactive approach, where safety experts and statisticians have been primarily focusing on the review of clinical ... -
A functional analysis of the spacer of V(D)J recombination signal sequences.
(PLoS Biol, 2003-10)During lymphocyte development, V(D)J recombination assembles antigen receptor genes from component V, D, and J gene segments. These gene segments are flanked by a recombination signal sequence (RSS), which serves as the ... -
A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.
(PLoS One, 2013)Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (rs6318) of the 5HTR2C gene located on the X-chromosome is associated with hypothalamic-pituitary-adrenal axis response to a stress ... -
A Genocentric Approach to Discovery of Mendelian Disorders.
(American journal of human genetics, 2019-11)The advent of inexpensive, clinical exome sequencing (ES) has led to the accumulation of genetic data from thousands of samples from individuals affected with a wide range of diseases, but for whom the underlying genetic ... -
A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting.
(BMC Infect Dis, 2014-02-13)BACKGROUND: Humans vary in their susceptibility to acquiring Staphylococcus aureus infection, and research suggests that there is a genetic basis for this variability. Several recent genome-wide association studies (GWAS) ... -
A hidden Markov model approach to analyze longitudinal ternary outcomes when some observed states are possibly misclassified
(Statistics in Medicine, 2016) -
A host gene expression approach for identifying triggers of asthma exacerbations.
(PloS one, 2019-01)RATIONALE:Asthma exacerbations often occur due to infectious triggers, but determining whether infection is present and whether it is bacterial or viral remains clinically challenging. A diagnostic strategy that clarifies ...
