Now showing items 1-5 of 5

    • COPD: balancing oxidants and antioxidants. 

      Fischer, Bernard Martin; Ghio, Andrew J; Voynow, JA (Int J Chron Obstruct Pulmon Dis, 2015)
      Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses in the world. The disease encompasses emphysema, chronic bronchitis, and small airway obstruction and can be caused by environmental ...
    • Deficiency of α-1-antitrypsin influences systemic iron homeostasis. 

      Fischer, Bernard Martin; Ghio, Andrew J; Richards, JH; Schmechel, DE; Soukup, JM; Voynow, JA (Int J Chron Obstruct Pulmon Dis, 2013)
      There is evidence that proteases and antiproteases participate in the iron homeostasis of cells and living systems. We tested the postulate that α-1 antitrypsin (A1AT) polymorphism and the consequent deficiency ...
    • Interactions of oxygen radicals with airway epithelium. 

      Wright, DT; Cohn, LA; Li, H; Fischer, Bernard Martin; Li, CM; Adler, KB (Environ Health Perspect, 1994-12)
      Reactive oxygen species (ROS) have been implicated in the pathogenesis of numerous disease processes. Epithelial cells lining the respiratory airways are uniquely vulnerable regarding potential for oxidative damage due to ...
    • Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation. 

      Fischer, Bernard Martin; Pavlisko, Elizabeth N; Voynow, JA (Int J Chron Obstruct Pulmon Dis, 2011)
      Patients with chronic obstructive pulmonary disease (COPD) exhibit dominant features of chronic bronchitis, emphysema, and/or asthma, with a common phenotype of airflow obstruction. COPD pulmonary physiology reflects the ...
    • The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates. 

      Martin, LD; Krunkosky, TM; Dye, JA; Fischer, Bernard Martin; Jiang, NF; Rochelle, LG; Akley, NJ; ... (9 authors) (Environ Health Perspect, 1997-09)
      Epidemiologic and occupational studies indicate adverse health effects due to inhalation of particulate air pollutants, but precise biologic mechanisms responsible have yet to be fully established. The tracheobronchial epithelium ...