Now showing items 1-8 of 8

    • A translatable predictor of human radiation exposure. 

      Abedi, M; Chao, Nelson J; Chute, JP; Dressman, HK; Himburg, Heather; Lucas, J; Minor, K; ... (12 authors) (PLoS One, 2014)
      Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate ...
    • Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. 

      Chao, Nelson J; Chute, JP; Doan, Phuong Linh; Fang, T; Himburg, Heather; Kan, J; Pohl, K; ... (12 authors) (Cell Rep, 2016-11-01)
      Imprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an ...
    • Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. 

      Chao, Nelson J; Chute, JP; Daher, P; Doan, Phuong Linh; Dressman, HK; Himburg, Heather; Lucas, J; ... (10 authors) (PLoS One, 2010-07-12)
      In the event of a terrorist-mediated attack in the United States using radiological or improvised nuclear weapons, it is expected that hundreds of thousands of people could be exposed to life-threatening levels of ionizing ...
    • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 

      Chao, Nelson J; Chute, JP; Deoliviera, D; Doan, Phuong Linh; Fixsen, Emma; Harris, Jeffrey R; Helms, K; ... (12 authors) (Nat Med, 2013-03)
      The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow serum of ...
    • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 

      Chao, Nelson J; Chute, JP; Dressman, HK; Ginsburg, Geoffrey Steven; Himburg, Heather; Meadows, Sarah K; Muramoto, Garrett G; ... (10 authors) (PLoS One, 2008-04-02)
      BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...
    • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 

      Chao, Nelson J; Chute, JP; Dressman, HK; Ginsburg, Geoffrey Steven; Himburg, Heather; Meadows, Sarah K; Muramoto, Garrett G; ... (10 authors) (PLoS One, 2008-04-02)
      BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...
    • Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. 

      Choi, SS; Chute, JP; Diehl, Anna Mae; Garman, Katherine S; Guy, Cynthia D; Himburg, Heather; Krüger, L; ... (16 authors) (Gut, 2016-04)
      OBJECTIVE: The ductular reaction (DR) involves mobilisation of reactive-appearing duct-like cells (RDC) along canals of Hering, and myofibroblastic (MF) differentiation of hepatic stellate cells (HSC) in the space of Disse. ...
    • Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. 

      Chao, Nelson J; Chute, JP; Doan, Phuong Linh; Himburg, Heather; Nakamura, M; Quarmyne, M; Yan, X; ... (8 authors) (J Clin Invest, 2015-01)
      Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine kinases (RTKs). Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signaling; however, the functions of receptor PTPs in ...