Now showing items 1-7 of 7

    • Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk. 

      Xie, Jichun; Owzar, Kouros; Wei, Qingyi; Abbruzzese, James; Hurwitz, Herbert; Duan, Bensong; Hu, Jiangfeng; ... (12 authors) (International journal of cancer, 2018-04)
      The platelet-derived growth factor (PDGF) signaling pathway plays important roles in development and progression of human cancers. In our study, we aimed to identify genetic variants of the PDGF pathway genes associated ...
    • Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. 

      Bourland, JD; Chao, Nelson J; Chen, BJ; Chute, JP; Cline, JM; Daher, P; Deoliveira, D; ... (16 authors) (PLoS One, 2010-06-16)
      Medications that can mitigate against radiation injury are limited. In this study, we investigated the ability of recombinant human growth hormone (rhGH) to mitigate against radiation injury in mice and nonhuman primates. ...
    • Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer. 

      Owzar, Kouros; Liu, Zhensheng; Xie, Jichun; Wei, Qingyi; Feng, Yun; Wang, Yanru; Liu, Hongliang; ... (25 authors) (Molecular carcinogenesis, 2018-02)
      The P38MAPK pathway participates in regulating cell cycle, inflammation, development, cell death, cell differentiation, and tumorigenesis. Genetic variants of some genes in the P38MAPK pathway are reportedly associated with ...
    • permGPU: Using graphics processing units in RNA microarray association studies. 

      George, Stephen L; Jung, SH; Owzar, Kouros; Shterev, ID (BMC Bioinformatics, 2010-06-16)
      BACKGROUND: Many analyses of microarray association studies involve permutation, bootstrap resampling and cross-validation, that are ideally formulated as embarrassingly parallel computing problems. Given that these analyses ...
    • Robust test method for time-course microarray experiments. 

      George, Stephen L; Jung, SH; Kim, S; Owzar, Kouros; Sohn, I (BMC Bioinformatics, 2010-07-22)
      BACKGROUND: In a time-course microarray experiment, the expression level for each gene is observed across a number of time-points in order to characterize the temporal trajectories of the gene-expression profiles. For many ...
    • Sample size calculation for studies with grouped survival data. 

      Li, Zhiguo; Owzar, Kouros; Wang, Xiaofei; Wu, Yuan (Statistics in medicine, 2018-06-10)
      Grouped survival data arise often in studies where the disease status is assessed at regular visits to clinic. The time to the event of interest can only be determined to be between two adjacent visits or is right censored ...
    • SNPpy--database management for SNP data from genome wide association studies. 

      Mitha, F; Herodotou, H; Borisov, N; Jiang, Chen; Yoder, J; Owzar, Kouros (PLoS One, 2011)
      BACKGROUND: We describe SNPpy, a hybrid script database system using the Python SQLAlchemy library coupled with the PostgreSQL database to manage genotype data from Genome-Wide Association Studies (GWAS). This system makes ...