Browsing by Author "0300144"
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Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay.
Pollara, Justin; Denny, Thomas; Ferrari, Guido; Tomaras, Georgia; Anderson, Lettie; Shen, Xiaoying; Orlandi, Chiara; ... (16 authors) (Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2018-04)Several different assay methodologies have been described for the evaluation of HIV or SIV-specific antibody-dependent cell-mediated cytotoxicity (ADCC). Commonly used assays measure ADCC by evaluating effector cell functions, ... -
Association of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1.
Brinkley, C; Deal, A; Denny, Thomas Norton; Edwards, RW; Ellington, S; Eudailey, Josh; Ferrari, Guido; ... (25 authors) (J Virol, 2015-10)UNLABELLED: Infants born to HIV-1-infected mothers in resource-limited areas where replacement feeding is unsafe and impractical are repeatedly exposed to HIV-1 throughout breastfeeding. Despite this, the majority of infants ... -
Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials
Berrong, Mark; Brown, S; Cox, J; D'Souza, M Patricia; Denny, Thomas Norton; Ferrari, Guido; Frahm, N; ... (19 authors) (Journal of Immunological Methods, 2014-01-01)A large repository of cryopreserved peripheral blood mononuclear cells (PBMCs) samples was created to provide laboratories testing the specimens from human immunodeficiency virus-1 (HIV-1) vaccine clinical trials the material ... -
Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials.
Berrong, Mark; Brown, S; Cox, J; D'Souza, M Patricia; Denny, Thomas Norton; Ferrari, Guido; Frahm, N; ... (19 authors) (J Immunol Methods, 2014-07)A large repository of cryopreserved peripheral blood mononuclear cells (PBMCs) samples was created to provide laboratories testing the specimens from human immunodeficiency virus-1 (HIV-1) vaccine clinical trials the material ... -
HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies.
Center for HIV/AIDS Vaccine Immunology; Denny, Thomas Norton; Ferrari, Guido; Fouda, Genevieve; Hahn, Beatrice H; Haynes, Barton Ford; Kalilani, L; ... (23 authors) (J Virol, 2011-09)Despite months of mucosal virus exposure, the majority of breastfed infants born to HIV-infected mothers do not become infected, raising the possibility that immune factors in milk inhibit mucosal transmission of HIV. HIV ... -
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.
Alam, S Munir; Blair, Lily M; Chao, A; Cocklin, SL; Dennison, SM; Duffy, R; Evans, A; ... (46 authors) (PLoS Pathog, 2015-08)HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies ... -
Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum.
Alam, S Munir; Anasti, Kara; Ferrari, Guido; Fouda, Genevieve; Friedman, J; Haynes, Barton Ford; Kelsoe, Garnett; ... (16 authors) (PLoS One, 2012)BACKGROUND: Generation of potent anti-HIV antibody responses in mucosal compartments is a potential requirement of a transmission-blocking HIV vaccine. HIV-specific, functional antibody responses are present in breast milk, ... -
Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques.
Bay, CP; De Paris, K; Dennis, ML; Eudailey, Josh; Ferrari, Guido; Fouda, Genevieve; Hudgens, MG; ... (16 authors) (mSphere, 2018-01)Mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) contributes to an estimated 150,000 new infections annually. Maternal vaccination has proven safe and effective at mitigating the impact ... -
Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission.
Alam, S Munir; Cai, Fangping; Chen, H; Datta, S; Denny, Thomas Norton; Ferrari, Guido; Fong, Y; ... (41 authors) (J Clin Invest, 2015-07-01)Despite the wide availability of antiretroviral drugs, more than 250,000 infants are vertically infected with HIV-1 annually, emphasizing the need for additional interventions to eliminate pediatric HIV-1 infections. Here, ... -
Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection.
Astronomo, RD; Ballweber-Fleming, L; Denny, Thomas Norton; Ferrari, Guido; Haynes, Barton Ford; Hensley-McBain, T; Hladik, F; ... (28 authors)HIV-1 infection occurs primarily through mucosal transmission. Application of biologically relevant mucosal models can advance understanding of the functional properties of antibodies that mediate HIV protection, thereby ...