Now showing items 1-7 of 7

    • A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2. 

      Carin, Lawrence; Chen, M; Gilbert, AG; Ginsburg, Geoffrey Steven; Glickman, Seth W; Hero, Alfred; Huang, Y; ... (17 authors) (PLoS One, 2013)
      There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional ...
    • An integrated transcriptome and expressed variant analysis of sepsis survival and death. 

      Cairns, CB; Carin, Lawrence; Corey, GR; Dinwiddie, DL; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Genome Med, 2014)
      BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ...
    • Are patients with longer emergency department wait times less likely to consent to research? 

      Ascher, S; Cairns, CB; Drake, Weiying; Freeman, D; Glickman, Seth W; Limkakeng, Alexander; Mani, G; ... (9 authors) (Acad Emerg Med, 2012-04)
      OBJECTIVES: There are unique challenges to enrolling patients in emergency department (ED) clinical research studies, including the time-sensitive nature of emergency conditions, the acute care environment, and the lack ...
    • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 

      Ahn, SH; Cairns, CB; Cyr, Derek; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; Kingsmore, Stephen F; ... (17 authors) (PLoS One, 2013)
      Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...
    • Host gene expression classifiers diagnose acute respiratory illness etiology. 

      Burke, T; Cairns, CB; Carin, Lawrence; Fowler, Vance Garrison Jr; Freeman, DH; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Sci Transl Med, 2016-01-20)
      Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...
    • Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients. 

      Chu, Vivian Hou; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; Himmel, T; Hudson, LL; Katz, JN; ... (14 authors) (Ann Am Thorac Soc, 2016-03)
      RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections often delay initiation of effective antimicrobial therapy. New diagnostic approaches offer potential clinical and cost-related improvements ...
    • Renal systems biology of patients with systemic inflammatory response syndrome. 

      Cairns, CB; Dinwiddie, DL; Fowler, Vance Garrison Jr; Glew, RH; Glickman, Seth W; Harrod, KS; Jaehne, AK; ... (21 authors) (Kidney Int, 2015-10)
      A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this, we examined the metabolome, proteome, ...