Now showing items 1-8 of 8

    • A longitudinal study of epigenetic variation in twins. 

      Ambler, A; Caspi, Avshalom; Craig, IW; Houts, Renate M; Mill, J; Moffitt, Terrie E; Williams, B; ... (8 authors) (Epigenetics, 2010-08-16)
      DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression. Alterations in DNA methylation are established contributors to inter-individual phenotypic variation and have been ...
    • Cardiorespiratory fitness and cognitive function in midlife: neuroprotection or neuroselection? 

      Belsky, Daniel W; Blumenthal, James Alan; Caspi, Avshalom; Israel, S; Moffitt, Terrie E; Poulton, R (Ann Neurol, 2015-04)
      OBJECTIVE: A study was undertaken to determine whether better cognitive functioning at midlife among more physically fit individuals reflects neuroprotection, by which fitness protects against age-related cognitive decline, ...
    • Childhood forecasting of a small segment of the population with large economic burden. 

      Belsky, Daniel W; Caspi, Avshalom; Harrington, Hona Lee; Hogan, Sean; Houts, Renate M; Moffitt, Terrie E; Poulton, R; ... (8 authors) (Nat Hum Behav, 2016)
      Policy-makers are interested in early-years interventions to ameliorate childhood risks. They hope for improved adult outcomes in the long run, bringing return on investment. How much return can be expected depends, partly, ...
    • Credit scores, cardiovascular disease risk, and human capital. 

      Belsky, Daniel W; Caspi, Avshalom; Harrington, Hona Lee; Hogan, Sean; Houts, Renate M; Israel, S; Moffitt, Terrie E; ... (10 authors) (Proc Natl Acad Sci U S A, 2014-12-02)
      Credit scores are the most widely used instruments to assess whether or not a person is a financial risk. Credit scoring has been so successful that it has expanded beyond lending and into our everyday lives, even to inform ...
    • How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment. 

      Caspi, Avshalom; Kokaua, J; Milne, BJ; Moffitt, Terrie E; Polanczyk, G; Poulton, R; Taylor, A (Psychol Med, 2010-06)
      BACKGROUND: Most information about the lifetime prevalence of mental disorders comes from retrospective surveys, but how much these surveys have undercounted due to recall failure is unknown. We compared results ...
    • Is chronic asthma associated with shorter leukocyte telomere length at midlife? 

      Belsky, Daniel W; Caspi, Avshalom; Hancox, RJ; Harrington, Hona Lee; Houts, Renate M; Moffitt, Terrie E; Poulton, R; ... (11 authors) (Am J Respir Crit Care Med, 2014-08-15)
      RATIONALE: Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging. OBJECTIVES: To test ...
    • Quantification of biological aging in young adults. 

      Belsky, Daniel W; Caspi, Avshalom; Cohen, Harvey Jay; Corcoran, DL; Danese, A; Harrington, Hona Lee; Houts, Renate M; ... (15 authors) (Proc Natl Acad Sci U S A, 2015-07-28)
      Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young ...
    • The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. 

      Belsky, Daniel W; Caspi, Avshalom; Corcoran, DL; Domingue, B; Harrington, Hona Lee; Hogan, Sean; Houts, Renate M; ... (12 authors) (Psychol Sci, 2016-07)
      A previous genome-wide association study (GWAS) of more than 100,000 individuals identified molecular-genetic predictors of educational attainment. We undertook in-depth life-course investigation of the polygenic score derived ...