Now showing items 1-3 of 3

    • An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. 

      Chisholm, AD; Chuang, M; E, Lezi; Eroglu, C; Koh, S; Matsunami, Hiroaki; Pujol, N; ... (10 authors) (Neuron, 2018-01-03)
      Infections have been identified as possible risk factors for aging-related neurodegenerative diseases, but it remains unclear whether infection-related immune molecules have a causative role in neurodegeneration during aging. ...
    • Astrocytes refine cortical connectivity at dendritic spines. 

      Bhagat, S; Calakos, Nicole; Calhan, OY; Eroglu, C; Kim, IH; Patel, S; Pilaz, LJ; ... (14 authors) (Elife, 2014-12-17)
      During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this ...
    • Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. 

      Dragatsis, I; Eroglu, C; Hayrapetyan, Volodya; Karadeniz, YB; McKinstry, SU; Ozlu, MI; Risher, WC; ... (12 authors) (J Neurosci, 2014-07-09)
      Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-Q) stretch in the huntingtin (Htt) protein. Gain-of-function effects of mutant Htt have been extensively investigated ...