Now showing items 1-7 of 7

    • Baseline Pulse Pressure, Acute Kidney Injury, and Mortality After Noncardiac Surgery. 

      Aronson, Solomon; Fontes, Manuel Lopes; Gan, Tong Joo; Karhausen, Jorn; Kertai, Miklos David; Li, Yi-Ju; Liu, W-W; ... (11 authors) (Anesth Analg, 2016-12)
      BACKGROUND: Increased pulse pressure (PP) is an important independent predictor of cardiovascular outcome and acute kidney injury (AKI) after cardiac surgery. The objective of this study was to determine whether elevated ...
    • Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. 

      Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team; Ji, Y; Kertai, Miklos David; Kraus, William Erle; Li, YJ; Li, YW; Mathew, Joseph P; ... (13 authors) (Kidney Int, 2015-10)
      Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following ...
    • Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery. 

      Alexander, John Hunter Peel; Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team; Ji, Y; Joseph, D; Kertai, Miklos David; Li, YJ; Li, YW; ... (11 authors) (BMJ Open, 2015-05-06)
      OBJECTIVES: Identification of patient subpopulations susceptible to develop myocardial infarction (MI) or, conversely, those displaying either intrinsic cardioprotective phenotypes or highly responsive to protective interventions ...
    • Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest. 

      Cheruku, S; Hughes, GC; Karhausen, Jorn; Kertai, Miklos David; Li, YJ; Mathew, Joseph P; Qi, W (J Thorac Cardiovasc Surg, 2017-01)
      OBJECTIVE: Aortic surgeries requiring hypothermic circulatory arrest evoke systemic inflammatory responses that often manifest as vasoplegia and hypotension. Because mast cells can rapidly release vasoactive and proinflammatory ...
    • Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery. 

      Akushevich, Igor; Cooter, Mary; Fontes, Manuel Lopes; Karhausen, Jorn; Kertai, Miklos David; Martinelli, SM; Podgoreanu, Mihai V; ... (9 authors) (Anesth Analg, 2017-06-17)
      BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting ...
    • Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery. 

      Aronson, Solomon; Cooter, Mary; Fontes, Manuel Lopes; Gaca, Jeffrey G; Jooste, Edmund H; Karhausen, Jorn; Kertai, Miklos David; ... (15 authors) (Anesthesiology, 2016-02)
      BACKGROUND: Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the ...
    • Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery. 

      Akushevich, Igor; Cardiothoracic Anesthesia Research Endeavors (CARE) Group; Esper, S; Fontes, Manuel Lopes; Ginsburg, Geoffrey Steven; Grichnik, Katherine Parker; Kertai, Miklos David; ... (13 authors) (J Thorac Cardiovasc Surg, 2014-04)
      OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality has been challenged. The conflicting results might have resulted from the extent of BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ...