Now showing items 1-4 of 4

    • Age-related changes in the cellular composition and epithelial organization of the mouse trachea. 

      Hogan, Brigid; Yu, Yen-Rei; Bowie, Emily; Wansleeben, Carolien; Hotten, Danielle F (PloS one, 2014-01)
      We report here senescent changes in the structure and organization of the mucociliary pseudostratified epithelium of the mouse trachea and main stem bronchi. We confirm previous reports of the gradual appearance of age-related, ...
    • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 

      Barkauskas, Christina; Hogan, Brigid; Bowie, Emily; Jain, Rajan; Takeda, Norifumi; Aghajanian, Haig; Wang, Qiaohong; ... (14 authors) (Nature communications, 2015-04-13)
      The plasticity of differentiated cells in adult tissues undergoing repair is an area of intense research. Pulmonary alveolar type II cells produce surfactant and function as progenitors in the adult, demonstrating ...
    • Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability. 

      Goetz, Sarah; Bowie, Emily; Norris, Ryan; Anderson, Kathryn V (PLoS genetics, 2018-12-10)
      Spinocerebellar ataxia type 11 (SCA11) is a rare, dominantly inherited human ataxia characterized by atrophy of Purkinje neurons in the cerebellum. SCA11 is caused by mutations in the gene encoding the Serine/Threonine kinase ...
    • Type 2 alveolar cells are stem cells in adult lung. 

      Hogan, Brigid; Barkauskas, Christina; Rackley, Craig; Bowie, Emily; Cronce, Michael J; Keene, Douglas R; Stripp, Barry R; ... (9 authors) (The Journal of clinical investigation, 2013-07)
      Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells. Here, we use a combination of in vivo ...