Browsing by Author "0603810"
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A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
(Open Forum Infect Dis, 2016-01)Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores ... -
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
(PLoS One, 2013)There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional ... -
Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies
(BMC BIOINFORMATICS, 2010-11-09) -
Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies.
(BMC Bioinformatics, 2010-11-09)BACKGROUND: Nonparametric Bayesian techniques have been developed recently to extend the sophistication of factor models, allowing one to infer the number of appropriate factors from the observed data. We consider such techniques ... -
Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.
(PLoS Genet, 2011-08)Exposure to influenza viruses is necessary, but not sufficient, for healthy human hosts to develop symptomatic illness. The host response is an important determinant of disease progression. In order to delineate host molecular ...
