Now showing items 1-5 of 5

    • Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. 

      Farris, AB; Gibby, Adriana C; Hong, JJ; Iwakoshi, Neal N; Kim, EJ; Kirk, Allan D; Knechtle, Stuart J; ... (9 authors) (Am J Transplant, 2014-01)
      De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion using anti-CD3 immunotoxin combined with ...
    • Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques. 

      Gibby, Adriana C; Hennigar, RA; Iwakoshi, Neal N; Jenkins, JB; Knechtle, Stuart J; Kwun, J; Leopardi, F; ... (11 authors) (Am J Transplant, 2012-09)
      Chronic allograft rejection is a major impediment to long-term transplant success. Humoral immune responses to alloantigens are a growing clinical problem in transplantation, with mounting evidence associating alloantibodies ...
    • Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment. 

      Bulut, OP; Farris, AB; Gibby, Adriana C; Iwakoshi, Neal N; Kim, DW; Kirk, Allan D; Knechtle, Stuart J; ... (13 authors) (Am J Transplant, 2012-10)
      Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development. Currently the antibody-mediated mechanisms during CR are poorly ...
    • Prevention trumps treatment of antibody-mediated transplant rejection. 

      Iwakoshi, Neal N; Knechtle, Stuart J; Kwun, J (J Clin Invest, 2010-04)
      Belying the spectacular success of solid organ transplantation and improvements in immunosuppressive therapy is the reality that long-term graft survival rates remain relatively unchanged, in large part due to chronic and ...
    • The role of B cells in solid organ transplantation. 

      Bulut, P; Dar, W; Iwakoshi, Neal N; Kim, E; Knechtle, Stuart J; Kwun, J; Oh, B; ... (8 authors) (Semin Immunol, 2012-04)
      The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreases either by intentional weaning ...