Now showing items 1-5 of 5

    • Detecting local haplotype sharing and haplotype association. 

      Guan, Yongtao; Xu, Hanli (Genetics, 2014-07)
      A novel haplotype association method is presented, and its power is demonstrated. Relying on a statistical model for linkage disequilibrium (LD), the method first infers ancestral haplotypes and their loadings at each marker ...
    • Detecting structure of haplotypes and local ancestry. 

      Guan, Yongtao (Genetics, 2014-03)
      We present a two-layer hidden Markov model to detect the structure of haplotypes for unrelated individuals. This allows us to model two scales of linkage disequilibrium (one within a group of haplotypes and one between groups), ...
    • Informative priors on fetal fraction increase power of the noninvasive prenatal screen. 

      Guan, Yongtao; Xu, Hanli; Wang, Shaowei; Ma, Lin-Lin; Huang, Shuai; Liang, Lin; Liu, Qian; ... (12 authors) (Genetics in medicine : official journal of the American College of Medical Genetics, 2017-11-09)
      PurposeNoninvasive prenatal screening (NIPS) sequences a mixture of the maternal and fetal cell-free DNA. Fetal trisomy can be detected by examining chromosomal dosages estimated from sequencing reads. The traditional method ...
    • On the Null Distribution of Bayes Factors in Linear Regression 

      Guan, Yongtao; Zhou, Quan (Journal of the American Statistical Association, 2017-07-27)
      © 2018 The Author(s). Published with license by Taylor & Francis We show that under the null, the (Formula presented.) is asymptotically distributed as a weighted sum of chi-squared random variables with a shifted mean. ...
    • Strong Selection at MHC in Mexicans since Admixture. 

      Guan, Yongtao; Zhou, Quan; Zhao, Liang (PLoS genetics, 2016-02-10)
      Mexicans are a recent admixture of Amerindians, Europeans, and Africans. We performed local ancestry analysis of Mexican samples from two genome-wide association studies obtained from dbGaP, and discovered that at the MHC ...