Browsing by Author "Abbruzzese, James L"
Now showing items 1-5 of 5
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Clinical Insights Into the Biology and Treatment of Pancreatic Cancer.
(J Oncol Pract, 2016-01)Pancreatic cancer is a devastating disease with a universally poor prognosis. In 2015, it is estimated that there will be 48,960 new cases of pancreatic cancer and that 40,560 people will die of the disease. The 5-year survival ... -
Development of a Novel c-MET-Based CTC Detection Platform.
(Mol Cancer Res, 2016-06)UNLABELLED: Amplification of the MET oncogene is associated with poor prognosis, metastatic dissemination, and drug resistance in many malignancies. We developed a method to capture and characterize circulating tumor cells ... -
Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.
(Molecular carcinogenesis, 2019-04-17)The liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway has been identified as a new target for cancer therapy, because it controls the glucose and lipid metabolism in response to alterations in nutrients and ... -
Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.
(Molecular carcinogenesis, 2020-05-05)Because the peroxisome proliferator-activated receptor (PPAR) signaling pathway is involved in development and progression of pancreatic cancer, we investigated associations between genetic variants of the PPAR pathway genes ... -
Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.
(Cancer science, 2019-06)Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles ...
