Browsing by Author "Alspaugh, J Andrew"

A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans.

Paes, Hugo Costa; Derengowski, Lorena da Silveira; Peconick, Luisa Defranco Ferreira; Albuquerque, Patrícia; Pappas, Georgios Joannis; Nicola, André Moraes; Silva, Fabiana Brandão Alves; ... (11 authors) (Frontiers in Cellular and Infection Microbiology, 2018-01)

Gti1/Pac2 transcription factors occur exclusively in fungi and their roles vary according to species, including regulating morphological transition and virulence, mating and secondary metabolism. Many of these functions ...

Campafungins: Inhibitors of Candida albicans and Cryptococcus neoformans Hyphal Growth.

Perlatti, Bruno; Harris, Guy; Nichols, Connie B; Ekanayake, Dulamini I; Alspaugh, J Andrew; Gloer, James B; Bills, Gerald F (Journal of natural products, 2020-09-03)

Campafungin A is a polyketide that was recognized in the Candida albicans fitness test due to its antiproliferative and antihyphal activity. Its mode of action was hypothesized to involve inhibition of a cAMP-dependent PKA ...

Characterization of additional components of the environmental pH-sensing complex in the pathogenic fungus Cryptococcus neoformans.

Pianalto, Kaila M; Ost, Kyla S; Brown, Hannah E; Alspaugh, J Andrew (The Journal of biological chemistry, 2018-06)

Pathogenic microorganisms must adapt to changes in their immediate surroundings, including alterations in pH, to survive the shift from the external environment to that of the infected host. In the basidiomycete fungal pathogen ...

Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition.

Esher, Shannon K; Ost, Kyla S; Kohlbrenner, Maria A; Pianalto, Kaila M; Telzrow, Calla L; Campuzano, Althea; Nichols, Connie B; ... (10 authors) (PLoS pathogens, 2018-06-04)

The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both in size and composition, upon entering the host. This cell wall remodeling is essential for host immune avoidance by this pathogen. ...

Discovery of Ibomycin, a Potent Antifungal Weapon.

Alspaugh, J Andrew (Cell Chem Biol, 2016-11-17)

In this issue of Cell Chemical Biology, Robbins et al. (2016) identify ibomycin, a unique compound with antifungal activity. Microbial physiological and genetic studies suggest that endocytic trafficking might be the site ...

Disseminated Adenovirus Infection After Combined Liver-Kidney Transplantation

Hemmersbach-Miller, Marion; Bailey, Emily S; Kappus, Matthew; Prasad, Vinod K; Gray, Gregory C; Alspaugh, J Andrew (FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2018-11-20)

HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence.

Brandão, Fabiana; Esher, Shannon K; Ost, Kyla S; Pianalto, Kaila; Nichols, Connie B; Fernandes, Larissa; Bocca, Anamélia L; ... (9 authors) (Scientific reports, 2018-03-26)

The human fungal pathogen Cryptococcus neoformans undergoes many phenotypic changes to promote its survival in specific ecological niches and inside the host. To explore the role of chromatin remodeling on the expression ...

Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay.

Xu, Lijian; Li, Yan; Biggins, John B; Bowman, Brian R; Verdine, Gregory L; Gloer, James B; Alspaugh, J Andrew; ... (8 authors) (Applied microbiology and biotechnology, 2018-03)

We used a temperature differential assay with the opportunistic fungal pathogen Cryptococcus neoformans as a simple screening platform to detect small molecules with antifungal activity in natural product extracts. By screening ...

Identification of the Antifungal Metabolite Chaetoglobosin P From Discosia rubi Using a Cryptococcus neoformans Inhibition Assay: Insights Into Mode of Action and Biosynthesis.

Perlatti, Bruno; Nichols, Connie B; Lan, Nan; Wiemann, Philipp; Harvey, Colin JB; Alspaugh, J Andrew; Bills, Gerald F (Frontiers in microbiology, 2020-01)

Cryptococcus neoformans is an important human pathogen with limited options for treatments. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth ...