Now showing items 1-13 of 13

    • Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival. 

      Luo, Sheng; Wei, Qingyi; Dai, Wei; Liu, Hongliang; Xu, Xinyuan; Ge, Jie; Zhu, Dakai; ... (13 authors) (International journal of cancer, 2019-02-08)
      Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively ...
    • Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival. 

      Liu, Zhensheng; Wei, Qingyi; Yin, Jieyun; Liu, Hongliang; Wang, Li-E; Chen, Wei V; Zhu, Dakai; ... (10 authors) (The Journal of investigative dermatology, 2015-02)
      Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived from published genome-wide association ...
    • Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. 

      Wei, Qingyi; Li, Bo; Wang, Yanru; Xu, Yinghui; Liu, Hongliang; Bloomer, Wendy; Zhu, Dakai; ... (12 authors) (International journal of cancer, 2018-06)
      Cutaneous melanoma (CM) is considered as a steroid hormone-related malignancy. However, few studies have evaluated the roles of genetic variants encoding steroid hormone receptor genes and their related regulators (SHR-related ...
    • Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival. 

      Xie, Jichun; Wei, Qingyi; Wang, Xiaomeng; Liu, Hongliang; Xu, Yinghui; Zhu, Dakai; Amos, Christopher I; ... (12 authors) (Carcinogenesis, 2018-12-29)
      Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark of cancer including cutaneous melanoma (CM). In the present study, using data from a published genome-wide association study (GWAS) from ...
    • Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival. 

      Hyslop, Terry; Wei, Qingyi; Xu, Yinghui; Wang, Yanru; Liu, Hongliang; Shi, Qiong; Zhu, Dakai; ... (12 authors) (Molecular carcinogenesis, 2018-01)
      Metzincins are key molecules in the degradation of the extracellular matrix and play an important role in cellular processes such as cell migration, adhesion, and cell fusion of malignant tumors, including cutaneous melanoma ...
    • Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium. 

      Liu, Zhensheng; Wei, Qingyi; Feng, Yun; Wang, Yanru; Liu, Hongliang; Mills, Coleman; Han, Younghun; ... (22 authors) (Scientific reports, 2017-04-11)
      The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway are associated with lung cancer risk and survival. ...
    • Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women. 

      Wei, Qingyi; Berchuck, Andrew; Lawrenson, Kate; Song, Fengju; Hazelett, Dennis J; Kar, Siddhartha P; Tyrer, Jonathan; ... (53 authors) (Gynecologic oncology, 2019-03-19)
      OBJECTIVE:Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian ...
    • Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. 

      Wei, Qingyi; Macgregor, Stuart; Montgomery, Grant W; Liu, Jimmy Z; Zhao, Zhen Zhen; Henders, Anjali K; Stark, Mitchell; ... (52 authors) (Nature genetics, 2011-10-09)
      We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized ...
    • Genome-wide association study identifies three new melanoma susceptibility loci. 

      Wei, Qingyi; Barrett, Jennifer H; Iles, Mark M; Harland, Mark; Taylor, John C; Aitken, Joanne F; Andresen, Per Arne; ... (75 authors) (Nature genetics, 2011-10-09)
      We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, ...
    • Inverse Relationship between Vitiligo-Related Genes and Skin Cancer Risk. 

      Wei, Qingyi; Wu, Wenting; Amos, Christopher I; Lee, Jeffrey E; Sarin, Kavita Y; Han, Jiali (The Journal of investigative dermatology, 2018-09)
    • Joint effect of multiple common SNPs predicts melanoma susceptibility. 

      Wei, Qingyi; Fang, Shenying; Han, Jiali; Zhang, Mingfeng; Wang, Li-e; Amos, Christopher I; Lee, Jeffrey E (PloS one, 2013-01)
      Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the ...
    • Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer. 

      Owzar, Kouros; Liu, Zhensheng; Xie, Jichun; Wei, Qingyi; Feng, Yun; Wang, Yanru; Liu, Hongliang; ... (25 authors) (Molecular carcinogenesis, 2018-02)
      The P38MAPK pathway participates in regulating cell cycle, inflammation, development, cell death, cell differentiation, and tumorigenesis. Genetic variants of some genes in the P38MAPK pathway are reportedly associated with ...
    • Polymorphisms of nucleotide excision repair genes predict melanoma survival. 

      Wei, Qingyi; Li, Chunying; Yin, Ming; Wang, Li-E; Amos, Christopher I; Zhu, Dakai; Lee, Jeffrey E; ... (9 authors) (The Journal of investigative dermatology, 2013-07)
      Melanoma is the most highly malignant skin cancer, and nucleotide excision repair (NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients, we evaluated whether genetic variants of NER genes ...