Browsing by Author "Angus, Derek C"

Now showing items 1-7 of 7

    • A Randomized Trial of Protocol-Based Care for Early Septic Shock 

      ProCESS Investigators; Yealy, Donald M; Kellum, John A; Huang, David T; Barnato, Amber E; Weissfeld, Lisa A; Pike, Francis; ... (14 authors) (New England Journal of Medicine, 2014-05)

    • Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. 

      Axfors, Cathrine; Schmitt, Andreas M; Janiaud, Perrine; Van't Hooft, Janneke; Abd-Elsalam, Sherief; Abdo, Ehab F; Abella, Benjamin S; ... (94 authors) (Nature communications, 2021-05-14)
      The original version of this Article contained an error in the spelling of the author Muhammad Shahzad, which was incorrectly given as Muhammad Shehzad. This has now been corrected in both the PDF and HTML versions of the ...

    • Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. 

      PRISM Investigators; Rowan, Kathryn M; Angus, Derek C; Bailey, Michael; Barnato, Amber E; Bellomo, Rinaldo; Canter, Ruth R; ... (24 authors) (The New England journal of medicine, 2017-06)
      BACKGROUND:After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. ...

    • Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. 

      Axfors, Cathrine; Schmitt, Andreas M; Janiaud, Perrine; Van't Hooft, Janneke; Abd-Elsalam, Sherief; Abdo, Ehab F; Abella, Benjamin S; ... (94 authors) (Nature communications, 2021-04-15)
      Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate ...

    • Sepsis Subclasses: A Framework for Development and Interpretation. 

      DeMerle, Kimberley M; Angus, Derek C; Baillie, J Kenneth; Brant, Emily; Calfee, Carolyn S; Carcillo, Joseph; Chang, Chung-Chou H; ... (30 authors) (Critical care medicine, 2021-05)
      Sepsis is defined as a dysregulated host response to infection that leads to life-threatening acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and is often deadly, even when evidence-based ...

    • Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. 

      REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; Goligher, Ewan C; Bradbury, Charlotte A; McVerry, Bryan J; Lawler, Patrick R; ... (171 authors) (The New England journal of medicine, 2021-08-04)
      <h4>Background</h4>Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes ...

    • Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. 

      ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler, Patrick R; Goligher, Ewan C; Berger, Jeffrey S; Neal, Matthew D; ... (181 authors) (The New England journal of medicine, 2021-08-04)
      <h4>Background</h4>Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve ...