Now showing items 1-5 of 5

    • Biomarkers of immunotherapy in urothelial and renal cell carcinoma: PD-L1, tumor mutational burden, and beyond. 

      Armstrong, AJ; Friedlander, TW; George, Daniel J; Kim, W; Pal, Sumanta K; Zhang, T; Zhu, Jason (J Immunother Cancer, 2018-01-25)
      Immune checkpoint inhibitors targeting the PD-1 pathway have greatly changed clinical management of metastatic urothelial carcinoma and metastatic renal cell carcinoma. However, response rates are low, and biomarkers are ...
    • Development of a Novel c-MET-Based CTC Detection Platform. 

      Abbruzzese, J; Armstrong, AJ; Boominathan, R; Connelly, MA; Foulk, B; Garcia-Blanco, Mariano Agustin; Gemberling, S; ... (20 authors) (Mol Cancer Res, 2016-06)
      UNLABELLED: Amplification of the MET oncogene is associated with poor prognosis, metastatic dissemination, and drug resistance in many malignancies. We developed a method to capture and characterize circulating tumor cells ...
    • Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. 

      Armstrong, AJ; Bepler, T; Buckley, Anne Frances; Epstein, JI; Garcia-Blanco, Mariano Agustin; Hish, AJ; Marengo, MS; ... (13 authors) (Oncogene, 2016-08-18)
      The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT and MET). Although there is substantial support ...
    • Docetaxel Resistance in Prostate Cancer: Taking It Up a Notch. 

      Zhang, T; Armstrong, AJ (Clin Cancer Res, 2015-10-15)
      Notch signaling is implicated in prostate cancer progression and docetaxel resistance. Cui and colleagues describe the additive efficacy and mechanisms of a γ-secretase inhibitor, PF-03084014, and docetaxel in preclinical ...
    • Evaluation of an epithelial plasticity biomarker panel in men with localized prostate cancer. 

      Armstrong, AJ; Freedland, SJ; Halabi, Susan; Healy, Patrick; Kemeny, G; Lark, A; Vollmer, Robin T; ... (8 authors) (Prostate Cancer Prostatic Dis, 2016-03)
      BACKGROUND: Given the potential importance of epithelial plasticity (EP) to cancer metastasis, we sought to investigate biomarkers related to EP in men with localized prostate cancer (PC) for the association with time to ...