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    • Informative priors on fetal fraction increase power of the noninvasive prenatal screen. 

      Guan, Yongtao; Xu, Hanli; Wang, Shaowei; Ma, Lin-Lin; Huang, Shuai; Liang, Lin; Liu, Qian; ... (12 authors) (Genetics in medicine : official journal of the American College of Medical Genetics, 2017-11-09)
      PurposeNoninvasive prenatal screening (NIPS) sequences a mixture of the maternal and fetal cell-free DNA. Fetal trisomy can be detected by examining chromosomal dosages estimated from sequencing reads. The traditional method ...