Browsing by Author "Berger, Miles"
Now showing items 1-19 of 19
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Awake spinal anesthesia facilitates spine surgery in poor surgical candidates: A case series.
(Neuro-Chirurgie, 2023-05)<h4>Background</h4>Annually, hundreds of thousands of patients undergo surgery for degenerative spine disease (DSD). This represents only a fraction of patients that present for surgical consideration. Procedures are often ... -
Awake Spinal Fusion Is Associated with Reduced Length of Stay, Opioid Use, and Time to Ambulation Compared to General Anesthesia: A Matched Cohort Study.
(World neurosurgery, 2023-05)<h4>Objective</h4>There is increasing interest in awake spinal fusion under spinal anesthesia (SA). Evidence supporting SA has been positive, albeit limited. The authors set out to investigate the effects of SA vs general ... -
Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.
(Journal of Alzheimer's disease : JAD, 2021-02-26)<h4>Background</h4>Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized ... -
Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.
(Anesthesia and analgesia, 2019-05-03)Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before ... -
Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.
(Scientific reports, 2021-02-04)Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) derived lipids play key roles in initiating and resolving inflammation. Neuro-inflammation is thought to play a causal role in perioperative ... -
Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.
(Front Syst Neurosci, 2017)Each year over 16 million older Americans undergo general anesthesia for surgery, and up to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and POCD are each associated with decreased quality ... -
Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study
(British Journal of Anaesthesia, 2021-09) -
Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.
(Annals of clinical and translational neurology, 2022-02)<h4>Objective</h4>Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship ... -
Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line
(2010)Background: Multicellular organisms are characterized by a remarkable diversity of morphologically distinct and functionally specialized cell types. Transgenic techniques for the manipulation of gene expression in specific ... -
Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings.
(J Am Geriatr Soc, 2017-01)OBJECTIVES: To look for changes in intrinsic functional brain connectivity associated with postoperative changes in cognition, a common complication in seniors undergoing major surgery, using resting-state functional magnetic ... -
Risk of Spinal Hematoma After Lumbar Puncture.
(JAMA, 2021-02) -
Sparcl1/Hevin drives pathological pain through spinal cord astrocyte and NMDA receptor signaling.
(JCI insight, 2022-10)Hevin/Sparcl1 is an astrocyte-secreted protein and regulates synapse formation. Here we show that astrocytic hevin signaling plays a critical role in maintaining chronic pain. Compared to wild-type mice, hevin-null mice ... -
State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018
(British Journal of Anaesthesia, 2019-08) -
Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.
(Hum Brain Mapp, 2017-11-21)OBJECTIVES: Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative ... -
The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.
(J Alzheimers Dis, 2016-04-15)BACKGROUND: Preclinical studies have found differential effects of isoflurane and propofol on the Alzheimer's disease (AD)-associated markers tau, phosphorylated tau (p-tau) and amyloid-β (Aβ). OBJECTIVE: We asked whether ... -
The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.
(Journal of the American Geriatrics Society, 2019-01-23)BACKGROUND/OBJECTIVES:Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated ... -
The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.
(Journal of Alzheimer's disease : JAD, 2020-01)BACKGROUND:Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative ... -
The potential link between obstructive sleep apnea and postoperative neurocognitive disorders: current knowledge and possible mechanisms.
(Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2022-08-18)<h4>Purpose</h4>This narrative review examines the current evidence on whether obstructive sleep apnea (OSA) is associated with postoperative delirium (POD) and postoperative cognitive dysfunction (POCD). The mechanisms ...
