Browsing by Author "Biernacka, Joanna"

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Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine-Learning Approach With Multi-trial Replication.

Athreya, Arjun P; Neavin, Drew; Carrillo-Roa, Tania; Skime, Michelle; Biernacka, Joanna; Frye, Mark A; Rush, A John; ... (12 authors) (Clinical pharmacology and therapeutics, 2019-10)

We set out to determine whether machine learning-based algorithms that included functionally validated pharmacogenomic biomarkers joined with clinical measures could predict selective serotonin reuptake inhibitor (SSRI) ...
Prediction of short-term antidepressant response using probabilistic graphical models with replication across multiple drugs and treatment settings.

Athreya, Arjun P; Brückl, Tanja; Binder, Elisabeth B; John Rush, A; Biernacka, Joanna; Frye, Mark A; Neavin, Drew; ... (17 authors) (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021-06)

Heterogeneity in the clinical presentation of major depressive disorder and response to antidepressants limits clinicians' ability to accurately predict a specific patient's eventual response to therapy. Validated depressive ...