Browsing by Author "Bisnett, Brittany J"

Now showing items 1-4 of 4

    • A novel glycoproteomics workflow reveals dynamic O-GlcNAcylation of COPγ1 as a candidate regulator of protein trafficking 

      Cox, Nathan J; Luo, Peter M; Smith, Timothy J; Bisnett, Brittany J; Soderblom, Erik J; Boyce, Michael (Frontiers in Endocrinology, 2018-10-15)
      Copyright © 2018 Cox, Luo, Smith, Bisnett, Soderblom and Boyce. O-linked ß-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation ...

    • Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. 

      Cox, Nathan J; Unlu, Gokhan; Bisnett, Brittany J; Meister, Thomas R; Condon, Brett M; Luo, Peter M; Smith, Timothy J; ... (13 authors) (Biochemistry, 2018-01)
      The COPII coat complex, which mediates secretory cargo trafficking from the endoplasmic reticulum, is a key control point for subcellular protein targeting. Because misdirected proteins cannot function, protein sorting by ...

    • Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock. 

      Bragg, Jack T; D'Ambrosio, Hannah K; Smith, Timothy J; Gorka, Caroline A; Khan, Faraz A; Rose, Joshua T; Rouff, Andrew J; ... (12 authors) (Chembiochem : a European journal of chemical biology, 2017-09)
      Trehalose is a disaccharide produced by many organisms to better enable them to survive environmental stresses, including heat, cold, desiccation, and reactive oxygen species. Mammalian cells do not naturally biosynthesize ...

    • Glycosylation of KEAP1 links nutrient sensing to redox stress signaling. 

      Chen, Po-Han; Smith, Timothy J; Wu, Jianli; Siesser, Priscila F; Bisnett, Brittany J; Khan, Farhan; Hogue, Maxwell; ... (14 authors) (The EMBO journal, 2017-08)
      O-GlcNAcylation is an essential, nutrient-sensitive post-translational modification, but its biochemical and phenotypic effects remain incompletely understood. To address this question, we investigated the global transcriptional ...